SMARCC2 and RELB

Number of citations of the paper that reports this interaction (PubMedID 14743216)
0

Data Source:
HPRD (in vitro)

		SMARCC2	RELB
Description		SWI/SNF related BAF chromatin remodeling complex subunit C2	RELB proto-oncogene, NF-kB subunit
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GO Annotations	Cellular Component	Kinetochore Chromatin Nucleus Nucleoplasm Nuclear Matrix SWI/SNF Complex RSC-type Complex Protein-containing Complex Brahma Complex NpBAF Complex NBAF Complex BBAF Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Transcription Repressor Complex Protein-containing Complex Synapse NF-kappaB Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding Histone Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Identical Protein Binding
	Biological Process	Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of G0 To G1 Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Regulation Of DNA-templated Transcription Inflammatory Response Canonical NF-kappaB Signal Transduction Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Antigen Processing And Presentation Lymphocyte Differentiation Negative Regulation Of Interferon-beta Production Circadian Regulation Of Gene Expression Response To Cytokine Non-canonical NF-kappaB Signal Transduction T-helper 1 Type Immune Response Myeloid Dendritic Cell Differentiation T-helper 1 Cell Differentiation Innate Immune Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Cellular Response To Osmotic Stress
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	Dectin-1 mediated noncanonical NF-kB signaling CD209 (DC-SIGN) signaling NIK-->noncanonical NF-kB signaling
Drugs
Diseases
GWAS		Asthma ( 31619474) Refractive error ( 32231278)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebral amyloid angiopathy in Alzheimer’s disease ( 34020725) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Red cell distribution width ( 32888494) Triglyceride levels ( 32154731)
Interacting Genes		27 interacting genes: ARRB2 ATXN1 ATXN1L BAZ1B CEBPA CSNK2A1 EWSR1 FUS GATA1 IFTAP ITCH ITSN1 KLF1 KRT27 MCPH1 NOVA1 PEX14 PHYHIP POLR2C RAB1B RBPMS RELB SP1 SRGAP3 TAF15 TERF1 USP7	26 interacting genes: BCL7A BUD31 CDK1 CTSL DPF2 EHMT2 EZH2 GSK3B HDAC6 KPNA2 KPNA6 MALT1 MAP1LC3A MT1M MTAP NFKB1 NFKB2 RELA SIN3A SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCE1 UQCRFS1 USP11
Entrez ID		6601	5971
HPRD ID		03437	06886
Ensembl ID		ENSG00000139613	ENSG00000104856
Uniprot IDs		F8VXC8 Q8TAQ2	D6R992 Q01201
PDB IDs		6KAG 6LTH 6LTJ 7VDV 7Y8R	8G8R
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process POZ Domain Binding Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Establishment Of Protein Localization To Telomere DNA-templated Transcription Nucleus Identical Protein Binding MRNA 3'-UTR Binding Regulation Of Establishment Of Protein Localization To Chromosome Negative Regulation Of Macromolecule Biosynthetic Process Nucleolus Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Transcription Repressor Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Molecular Adaptor Activity Regulation Of Chromosome Condensation Negative Regulation Of RNA Metabolic Process DNA Binding Myeloid Cell Apoptotic Process Macromolecule Biosynthetic Process Regulation Of Hematopoietic Stem Cell Proliferation Positive Regulation Of RNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process Postsynapse Regulation Of Chromosome Organization Myeloid Cell Differentiation Rhythmic Process Transcription Cis-regulatory Region Binding Nucleic Acid Metabolic Process Chromatin Binding Granulocyte Differentiation Memory Regulation Of Transcription By RNA Polymerase II	Regulation Of Nucleotide-excision Repair SWI/SNF Complex NBAF Complex Regulation Of G0 To G1 Transition Positive Regulation Of Stem Cell Population Maintenance Regulation Of Sister Chromatid Segregation NpBAF Complex Regulation Of Stem Cell Population Maintenance Regulation Of Chromosome Segregation RSC-type Complex Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Chromatin Remodeling Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Developmental Process Chromatin Chromatin Organization Regulation Of G1/S Transition Of Mitotic Cell Cycle Nucleosome Disassembly Positive Regulation Of Double-strand Break Repair Protein-DNA Complex Disassembly Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Cell Differentiation Nucleoplasm BBAF Complex Regulation Of DNA Metabolic Process Positive Regulation Of DNA Repair Positive Regulation Of Cell Differentiation Protein-containing Complex Disassembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Regulation Of Double-strand Break Repair Regulation Of Chromosome Organization Nucleosomal DNA Binding Brahma Complex Positive Regulation Of DNA Metabolic Process Positive Regulation Of Myoblast Differentiation Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of T Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA Repair Cellular Response To Hydrogen Peroxide Positive Regulation Of Lymphocyte Differentiation Regulation Of Cellular Response To Stress Regulation Of Cell Cycle Process Regulation Of Multicellular Organismal Process
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