SMARCC2 and SRGAP3

Number of citations of the paper that reports this interaction (PMID 12368262)
35

Data Source:
HPRD (in vivo)

		SMARCC2	SRGAP3
Gene Name		SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	SLIT-ROBO Rho GTPase activating protein 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleoplasm SWI/SNF Complex Transcriptional Repressor Complex Protein Complex NpBAF Complex NBAF Complex	Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding	Protein Binding Rac GTPase Activator Activity Rac GTPase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Involved In Forebrain Neuron Fate Commitment ATP-dependent Chromatin Remodeling Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated	Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Migration Positive Regulation Of Rac GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines	Inactivation of Cdc42 and Rac Rho GTPase cycle Axon guidance Signaling by Rho GTPases Signaling by Robo receptor
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: ARRB2 ATXN1 ATXN1L BAZ1B C11orf74 CSNK2A1 GATA1 ITCH ITSN1 KLF1 MCPH1 NOVA1 PEX14 PHYHIP POLR2C RAB1B RELB SP1 SRGAP3 TERF1 TERF2IP	9 interactors: DISC1 DTNBP1 FASLG KDM1A PRMT6 SMARCC2 SUV39H1 TNIK WASF1
Entrez ID		6601	9901
HPRD ID		03437	12108
Ensembl ID		ENSG00000139613	ENSG00000196220
Uniprot IDs		F8VXC8 Q8TAQ2	O43295
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Gene Expression Regulation Of Cellular Process Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Chromosome Organization Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Developmental Process Nitrogen Compound Metabolic Process Regulation Of Signaling Myeloid Cell Differentiation Negative Regulation Of Chromosome Organization Regulation Of Organelle Organization Biosynthetic Process Regulation Of Cellular Component Organization Anatomical Structure Development Negative Regulation Of Binding Erythrocyte Differentiation System Development Rhythmic Process Response To Stimulus Erythrocyte Homeostasis Regulation Of Telomere Maintenance Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Gene Expression RNA-dependent DNA Replication Megakaryocyte Differentiation Myeloid Cell Homeostasis Organ Development	Organelle Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cell Differentiation Chromatin Modification Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Chromatin Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Neural Precursor Cell Proliferation Actin Cytoskeleton Reorganization Positive Regulation Of Stem Cell Proliferation Histone Modification Chromosome Organization Regulation Of Primitive Erythrocyte Differentiation Endomembrane System Organization Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Forebrain Development Cytoskeleton Organization Regulation Of Metabolic Process Regulation Of Neural Precursor Cell Proliferation Nervous System Development Histone H3-R2 Methylation Transcription, DNA-templated Developmental Process Regulation Of Stem Cell Proliferation RNA Biosynthetic Process Histone Methylation Endosomal Lumen Acidification Actin Cytoskeleton Organization Response To Stimulus Positive Regulation Of Cellular Metabolic Process Actin Filament-based Process Retinal Cell Programmed Cell Death System Development Generation Of Neurons Regulation Of Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Involved In Forebrain Neuron Fate Commitment Protein Methylation Regulation Of Cellular Process Necroptotic Signaling Pathway Neurogenesis Brain Development Histone H3-K9 Dimethylation Regulation Of Dopamine Receptor Signaling Pathway Head Development Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation
Tagcloud ?		affymetrix arrays c10orf18 cabp4 capn10 centb1 converted fdr fractioned genechip glycerol hybridized or4c6 papillary ran sall1 serous spata13 splicing st st18 subcellular supernatants supraspliceosome transcriptome wdr78 znf263 zp2 zranb2	3p anomalies arm camk1 congenital creld1 define deleted deletion deletions features give handicap interstitial involve kb lengths mb mtmr14 overlap presents prove respect rise seizures syndrome tada3 terminus typical
Tagcloud (Difference) ?		affymetrix arrays c10orf18 cabp4 capn10 centb1 converted fdr fractioned genechip glycerol hybridized or4c6 papillary ran sall1 serous spata13 splicing st st18 subcellular supernatants supraspliceosome transcriptome wdr78 znf263 zp2 zranb2	3p anomalies arm camk1 congenital creld1 define deleted deletion deletions features give handicap interstitial involve kb lengths mb mtmr14 overlap presents prove respect rise seizures syndrome tada3 terminus typical
Tagcloud (Intersection) ?