PRRX1 and TNFRSF4

Data Source: HiPPIP (Novel)

		PRRX1	TNFRSF4
Name		paired related homeobox 1	TNF receptor superfamily member 4
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding HMG Box Domain Binding	Virus Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Smoothened Signaling Pathway Mesenchymal Cell Proliferation Embryonic Limb Morphogenesis Inner Ear Morphogenesis Middle Ear Morphogenesis Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Determination Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Artery Morphogenesis Cartilage Development Roof Of Mouth Development Regulation Of Neuron Projection Regeneration Stem Cell Proliferation Neuronal Stem Cell Population Maintenance Positive Regulation Of Stem Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Immunoglobulin Production Inflammatory Response Immune Response Positive Regulation Of B Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation Symbiont Entry Into Host Cell
Pathways		None	TNFs bind their physiological receptors
GWAS		A body shape index ( 34021172 ) Appendicular lean mass ( 33097823 ) Atrial fibrillation ( 22544366 29892015 29290336 28416822 28416818 ) Calcific aortic valve stenosis ( 32141789 ) Central corneal thickness ( 32528159 ) Early onset atrial fibrillation ( 28460022 ) Emphysema imaging phenotypes ( 26030696 ) Estimated glomerular filtration rate ( 31152163 ) Heel bone mineral density ( 28869591 30598549 ) Height ( 31562340 ) Hip circumference adjusted for BMI ( 34021172 28552196 25673412 ) Hip index ( 34021172 ) Intraocular pressure ( 29617998 ) Macular thickness ( 30535121 ) Male-pattern baldness ( 28196072 29146897 ) PR interval ( 32439900 ) Prevalent atrial fibrillation ( 28416818 ) Refractive error ( 32231278 ) Response to angiotensin II receptor blocker therapy ( 22566498 ) Systemic lupus erythematosus ( 33536424 ) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Inflammatory bowel disease ( 23128233 )
Novel Interactors		3 novel interactors: ATP1B1 QSOX1 TNFRSF4	8 novel interactors: BTG2 DHX38 H6PD LUZP1 MAPK14 MLLT6 NAP1L5 PRRX1
Interacting Genes		8 interacting genes: CINP GTF2I MAFF MAFG SAAL1 SOX10 SRF SUOX	10 interacting genes: NUFIP2 RC3H1 SIVA1 TNFRSF9 TNFSF4 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5
Entrez ID		5396	7293
HPRD ID		01337	02636
Ensembl ID		ENSG00000116132	ENSG00000186827
Uniprot IDs		P54821	A0A8V8TQH5 P43489
PDB IDs		Not available	1D0A 2HEV 2HEY 6OGX 6OKM 6OKN 7YK4 8AG1
GO Terms Enriched among Interactors		DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Multicellular Organism Development Chordate Embryonic Development In Utero Embryonic Development Embryo Development Ending In Birth Or Egg Hatching DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Regulation Of Epidermis Development Negative Regulation Of RNA Biosynthetic Process Regulation Of Epidermal Cell Differentiation Serum Response Element Binding Sulfite Oxidase Activity Protein Transport Into Plasma Membrane Raft Regulation Of Multicellular Organismal Development Negative Regulation Of RNA Metabolic Process Bronchus Cartilage Development Lung Smooth Muscle Development Protein Transport Into Membrane Raft DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Population Proliferation Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Flavin-dependent Sulfhydryl Oxidase Activity Stem Cell Differentiation Cellular Response To Progesterone Stimulus Trachea Cartilage Development Cardiac Vascular Smooth Muscle Cell Differentiation Molybdenum Ion Binding Positive Regulation Of Synoviocyte Proliferation Positive Regulation Of Potassium Ion Import Across Plasma Membrane Protein Localization To Plasma Membrane Raft Positive Regulation Of Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Molybdopterin Cofactor Binding	Tumor Necrosis Factor Receptor Binding Thioesterase Binding Tumor Necrosis Factor-mediated Signaling Pathway Signaling Adaptor Activity CD40 Receptor Complex Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Ubiquitin Protein Ligase Binding Regulation Of MRNA Metabolic Process Tumor Necrosis Factor Receptor Superfamily Binding Regulation Of DNA-binding Transcription Factor Activity Regulation Of MRNA Stability MRNA Stabilization CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of RNA Stability Cell Surface Receptor Signaling Pathway Negative Regulation Of MRNA Catabolic Process RNA Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of RNA Catabolic Process Protein Phosphatase Binding Negative Regulation Of MRNA Metabolic Process Cytoplasmic Side Of Plasma Membrane Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of T-helper Cell Differentiation Regulation Of Immune Response Post-transcriptional Regulation Of Gene Expression Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Zinc Ion Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of T Cell Cytokine Production Ubiquitin Protein Ligase Activity Negative Regulation Of Alpha-beta T Cell Differentiation Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune Response Negative Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Immune System Process Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Interleukin-12 Production Regulation Of T Cell Proliferation TORC2 Complex Disassembly Regulation Of T Cell Cytokine Production