PRRX1 and QSOX1

Data Source: HiPPIP (Novel)

		PRRX1	QSOX1
Name		paired related homeobox 1	quiescin sulfhydryl oxidase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Membrane Platelet Alpha Granule Lumen Specific Granule Lumen Extracellular Exosome Tertiary Granule Lumen
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding HMG Box Domain Binding	Protein Disulfide Isomerase Activity Oxidoreductase Activity Flavin-dependent Sulfhydryl Oxidase Activity Thiol Oxidase Activity FAD Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Smoothened Signaling Pathway Mesenchymal Cell Proliferation Embryonic Limb Morphogenesis Inner Ear Morphogenesis Middle Ear Morphogenesis Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Determination Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Artery Morphogenesis Cartilage Development Roof Of Mouth Development Regulation Of Neuron Projection Regeneration Stem Cell Proliferation Neuronal Stem Cell Population Maintenance Positive Regulation Of Stem Cell Proliferation	Protein Folding Negative Regulation Of Macroautophagy Extracellular Matrix Assembly
Pathways		None	Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation
GWAS		A body shape index ( 34021172 ) Appendicular lean mass ( 33097823 ) Atrial fibrillation ( 22544366 29892015 29290336 28416822 28416818 ) Calcific aortic valve stenosis ( 32141789 ) Central corneal thickness ( 32528159 ) Early onset atrial fibrillation ( 28460022 ) Emphysema imaging phenotypes ( 26030696 ) Estimated glomerular filtration rate ( 31152163 ) Heel bone mineral density ( 28869591 30598549 ) Height ( 31562340 ) Hip circumference adjusted for BMI ( 34021172 28552196 25673412 ) Hip index ( 34021172 ) Intraocular pressure ( 29617998 ) Macular thickness ( 30535121 ) Male-pattern baldness ( 28196072 29146897 ) PR interval ( 32439900 ) Prevalent atrial fibrillation ( 28416818 ) Refractive error ( 32231278 ) Response to angiotensin II receptor blocker therapy ( 22566498 ) Systemic lupus erythematosus ( 33536424 ) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Anorexia nervosa ( 23568457 ) Pulse pressure ( 30224653 30578418 )
Novel Interactors		3 novel interactors: ATP1B1 QSOX1 TNFRSF4	9 novel interactors: AKIP1 CREG1 GPR52 GREM2 KIF5B PHAF1 PRRX1 SERPINC1 TNR
Interacting Genes		8 interacting genes: CINP GTF2I MAFF MAFG SAAL1 SOX10 SRF SUOX	7 interacting genes: BEGAIN CCR1 CCR6 CHRM4 SHANK3 UBE2D2 UBQLN4
Entrez ID		5396	5768
HPRD ID		01337	06785
Ensembl ID		ENSG00000116132	ENSG00000116260
Uniprot IDs		P54821	A0A140VKE5 O00391
PDB IDs		Not available	3LLI 3LLK 3Q6O 4IJ3
GO Terms Enriched among Interactors		DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Multicellular Organism Development Chordate Embryonic Development In Utero Embryonic Development Embryo Development Ending In Birth Or Egg Hatching DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Regulation Of Epidermis Development Negative Regulation Of RNA Biosynthetic Process Regulation Of Epidermal Cell Differentiation Serum Response Element Binding Sulfite Oxidase Activity Protein Transport Into Plasma Membrane Raft Regulation Of Multicellular Organismal Development Negative Regulation Of RNA Metabolic Process Bronchus Cartilage Development Lung Smooth Muscle Development Protein Transport Into Membrane Raft DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Population Proliferation Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Flavin-dependent Sulfhydryl Oxidase Activity Stem Cell Differentiation Cellular Response To Progesterone Stimulus Trachea Cartilage Development Cardiac Vascular Smooth Muscle Cell Differentiation Molybdenum Ion Binding Positive Regulation Of Synoviocyte Proliferation Positive Regulation Of Potassium Ion Import Across Plasma Membrane Protein Localization To Plasma Membrane Raft Positive Regulation Of Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Molybdopterin Cofactor Binding	G Protein-coupled Receptor Activity Chemokine Receptor Activity Dendritic Cell Migration Dendritic Cell Chemotaxis C-C Chemokine Binding C-C Chemokine Receptor Activity Positive Regulation Of Synaptic Transmission Regulation Of Neuron Projection Regeneration Positive Regulation Of Synaptic Transmission, Glutamatergic