PRRX1 and MAFG

Number of citations of the paper that reports this interaction (PMID 11036080)
10

Data Source:
HPRD (in vitro, in vivo)

		PRRX1	MAFG
Gene Name		paired related homeobox 1	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus	Nucleoplasm
	Molecular Function	Transcription Coactivator Activity Sequence-specific DNA Binding HMG Box Domain Binding	Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Mesenchymal Cell Proliferation Embryonic Limb Morphogenesis Inner Ear Morphogenesis Middle Ear Morphogenesis Positive Regulation Of Smoothened Signaling Pathway Embryonic Cranial Skeleton Morphogenesis Artery Morphogenesis Cartilage Development Palate Development	In Utero Embryonic Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Blood Coagulation Adult Behavior Regulation Of Cellular PH Regulation Of Cell Proliferation Regulation Of Epidermal Cell Differentiation
Pathways			Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Atrial fibrillation ( 22544366) Response to angiotensin II receptor blocker therapy ( 22566498)
Protein-Protein Interactions		5 interactors: GTF2I MAFF MAFG SOX10 SRF	26 interactors: ATF3 BACH1 BACH2 BATF3 CHD3 CREBBP CYP2E1 DDIT3 GTF2A1L HIF1A HOXD12 MAF MAFF MED31 NFE2 NFE2L1 NFE2L2 NFE2L3 NFIL3 PAX6 PIDD1 PPP1CA PRRX1 RBM48 SNRPN VIM
Entrez ID		5396	4097
HPRD ID		01337	03605
Ensembl ID		ENSG00000116132	ENSG00000197063
Uniprot IDs		P54821	O15525
PDB IDs
Enriched GO Terms of Interacting Partners?		In Utero Embryonic Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Embryo Development Regulation Of Epidermal Cell Differentiation RNA Metabolic Process Blood Coagulation Hemostasis Gene Expression Regulation Of Epidermis Development Cellular Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Macromolecule Biosynthetic Process Cellular Chemical Homeostasis Regulation Of Body Fluid Levels Wound Healing Regulation Of Transcription, DNA-templated Contractile Actin Filament Bundle Assembly Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Homeostasis Regulation Of RNA Metabolic Process Response To Wounding Nucleobase-containing Compound Metabolic Process Regulation Of Epithelial Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Transition Between Slow And Fast Fiber Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Chemical Homeostasis Ameboidal-type Cell Migration Negative Regulation Of Beta-amyloid Clearance Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Positive Regulation Of Transcription By Glucose Regulation Of Beta-amyloid Clearance Developmental Growth Cardiac Vascular Smooth Muscle Cell Differentiation Regulation Of Transcription By Glucose Tangential Migration From The Subventricular Zone To The Olfactory Bulb Stem Cell Differentiation Striated Muscle Tissue Development Carbon Catabolite Regulation Of Transcription	Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cellular Process Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Cellular Metabolic Process Limb Development Positive Regulation Of Stem Cell Proliferation Response To Stress Developmental Process MRNA Transcription From RNA Polymerase II Promoter System Development Organ Development
Tagcloud ?		abundant anterior bait cdna cloned cloning diencephalon differentiating fshbeta gland homeobox hybrid library lobe participating periods pituitary porcine pou primordium progenitor prop1 prrx2 retina rpf1 sequence transcripts upstream yeast	albeit arrested asymmetric constitute dimerizes dissect e2 erythroid heterodimeric lineages livers maff mafk megakaryocyte megakaryocytes megakaryocytic mpl nucleotides outside p18 p45 polypeptides predominate profound rarity readily recognizes thrombocytopenia
Tagcloud (Difference) ?		abundant anterior bait cdna cloned cloning diencephalon differentiating fshbeta gland homeobox hybrid library lobe participating periods pituitary porcine pou primordium progenitor prop1 prrx2 retina rpf1 sequence transcripts upstream yeast	albeit arrested asymmetric constitute dimerizes dissect e2 erythroid heterodimeric lineages livers maff mafk megakaryocyte megakaryocytes megakaryocytic mpl nucleotides outside p18 p45 polypeptides predominate profound rarity readily recognizes thrombocytopenia
Tagcloud (Intersection) ?