PRRX1 and CINP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRRX1	CINP
Description		paired related homeobox 1	cyclin dependent kinase 2 interacting protein
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding HMG Box Domain Binding	Protein Binding Preribosome Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Smoothened Signaling Pathway Mesenchymal Cell Proliferation Embryonic Limb Morphogenesis Inner Ear Morphogenesis Middle Ear Morphogenesis Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Determination Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Artery Morphogenesis Cartilage Development Roof Of Mouth Development Regulation Of Neuron Projection Regeneration Stem Cell Proliferation Neuronal Stem Cell Population Maintenance Positive Regulation Of Stem Cell Proliferation	DNA Replication DNA Repair DNA Damage Response Ribosome Biogenesis Ribosomal Large Subunit Biogenesis Cell Division
Pathways
Drugs
Diseases
GWAS		A body shape index ( 34021172) Appendicular lean mass ( 33097823) Atrial fibrillation ( 22544366 29892015 29290336 28416822 28416818) Calcific aortic valve stenosis ( 32141789) Central corneal thickness ( 32528159) Early onset atrial fibrillation ( 28460022) Emphysema imaging phenotypes ( 26030696) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172 28552196 25673412) Hip index ( 34021172) Intraocular pressure ( 29617998) Macular thickness ( 30535121) Male-pattern baldness ( 28196072 29146897) PR interval ( 32439900) Prevalent atrial fibrillation ( 28416818) Refractive error ( 32231278) Response to angiotensin II receptor blocker therapy ( 22566498) Systemic lupus erythematosus ( 33536424) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Body mass index ( 26426971) Refractive error ( 32231278)
Interacting Genes		8 interacting genes: CINP GTF2I MAFF MAFG SAAL1 SOX10 SRF SUOX	43 interacting genes: AIRIM AMOTL2 APP ATRIP BAALC BLZF1 BTBD2 CCDC112 CCDC33 CDK2 CFAP161 CLUAP1 COG3 DRC4 FAM161B FBF1 FNDC11 GOLGA2 HNRNPD INCA1 KANK2 MAGEA3 MEOX2 MINAR1 MMADHC MZT1 NDUFB7 PATJ PAX6 POU6F2 PRC1 PRRX1 PSMA1 REL SERTAD1 SNRPD2 SP2 SYCE1 TEPSIN TXNRD3 ZBTB42 ZNF19 ZNF620
Entrez ID		5396	51550
HPRD ID		01337	16715
Ensembl ID		ENSG00000116132	ENSG00000100865
Uniprot IDs		P54821	Q9BW66
PDB IDs			8CIH 8RHN
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Multicellular Organism Development Chordate Embryonic Development In Utero Embryonic Development Embryo Development Ending In Birth Or Egg Hatching DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Regulation Of Epidermis Development Negative Regulation Of RNA Biosynthetic Process Regulation Of Epidermal Cell Differentiation Serum Response Element Binding Sulfite Oxidase Activity Protein Transport Into Plasma Membrane Raft Regulation Of Multicellular Organismal Development Negative Regulation Of RNA Metabolic Process Bronchus Cartilage Development Lung Smooth Muscle Development Protein Transport Into Membrane Raft DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Population Proliferation Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Flavin-dependent Sulfhydryl Oxidase Activity Stem Cell Differentiation Cellular Response To Progesterone Stimulus Trachea Cartilage Development Cardiac Vascular Smooth Muscle Cell Differentiation Molybdenum Ion Binding Positive Regulation Of Synoviocyte Proliferation Positive Regulation Of Potassium Ion Import Across Plasma Membrane Protein Localization To Plasma Membrane Raft Positive Regulation Of Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Molybdopterin Cofactor Binding	Protein Binding
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