PRRX1 and GTF2I

Number of citations of the paper that reports this interaction (PMID 9334314)
34

Data Source:
BioGRID (biochemical)
HPRD (in vitro, in vivo)

		PRRX1	GTF2I
Gene Name		paired related homeobox 1	general transcription factor IIi
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus	Nucleus Nucleoplasm Cytoplasm Membrane Cell Projection Neuronal Cell Body
	Molecular Function	Transcription Coactivator Activity Sequence-specific DNA Binding HMG Box Domain Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Mesenchymal Cell Proliferation Embryonic Limb Morphogenesis Inner Ear Morphogenesis Middle Ear Morphogenesis Positive Regulation Of Smoothened Signaling Pathway Embryonic Cranial Skeleton Morphogenesis Artery Morphogenesis Cartilage Development Palate Development	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Transition Between Slow And Fast Fiber Negative Regulation Of Angiogenesis Negative Regulation Of Cytosolic Calcium Ion Concentration
Pathways
Drugs
Diseases
GWAS		Atrial fibrillation ( 22544366) Response to angiotensin II receptor blocker therapy ( 22566498)
Protein-Protein Interactions		5 interactors: GTF2I MAFF MAFG SOX10 SRF	35 interactors: AP2B1 AP4S1 ATF6 BCL2L11 BTK C4BPA CALM1 DPY30 GCC1 HDAC3 JAK2 LSM8 MAP3K3 MAPK12 MAPK3 MTUS2 MYC NFKB2 PIAS2 POU2AF1 PRKG1 PRRX1 SLU7 SMAD2 SNRPN SRC SRF STAT1 STAT3 TAB2 TRAF6 USF1 YY1 ZBTB17 ZMYM3
Entrez ID		5396	2969
HPRD ID		01337	03399
Ensembl ID		ENSG00000116132	ENSG00000077809
Uniprot IDs		P54821	A8K9W7 P78347 Q499G6 Q86U51
PDB IDs			2D9B 2DN4 2ED2 2EJE
Enriched GO Terms of Interacting Partners?		In Utero Embryonic Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Embryo Development Regulation Of Epidermal Cell Differentiation RNA Metabolic Process Blood Coagulation Hemostasis Gene Expression Regulation Of Epidermis Development Cellular Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Macromolecule Biosynthetic Process Cellular Chemical Homeostasis Regulation Of Body Fluid Levels Wound Healing Regulation Of Transcription, DNA-templated Contractile Actin Filament Bundle Assembly Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Homeostasis Regulation Of RNA Metabolic Process Response To Wounding Nucleobase-containing Compound Metabolic Process Regulation Of Epithelial Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Transition Between Slow And Fast Fiber Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Chemical Homeostasis Ameboidal-type Cell Migration Negative Regulation Of Beta-amyloid Clearance Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Positive Regulation Of Transcription By Glucose Regulation Of Beta-amyloid Clearance Developmental Growth Cardiac Vascular Smooth Muscle Cell Differentiation Regulation Of Transcription By Glucose Tangential Migration From The Subventricular Zone To The Olfactory Bulb Stem Cell Differentiation Striated Muscle Tissue Development Carbon Catabolite Regulation Of Transcription	Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Gene Expression Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stress RNA Metabolic Process Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Gene Expression Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Response To Stimulus Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Gene Expression Cellular Response To Stimulus Positive Regulation Of Protein Phosphorylation Growth Hormone Receptor Signaling Pathway Regulation Of Innate Immune Response Cellular Response To Growth Hormone Stimulus MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Transferase Activity Cell Communication Multicellular Organismal Development Toll-like Receptor 4 Signaling Pathway Regulation Of Immune System Process
Tagcloud ?		abundant anterior bait cdna cloned cloning diencephalon differentiating fshbeta gland homeobox hybrid library lobe participating periods pituitary porcine pou primordium progenitor prop1 prrx2 retina rpf1 sequence transcripts upstream yeast	74146970t ab aggressive assessment bap1 carcinomas cdkn2a classification complement cyld delta facilitate indolent isoforms missense mutation next notably pbrm1 rarely recurrent sequencing stimulate subtype subtypes tets thymic thymomas tp53
Tagcloud (Difference) ?		abundant anterior bait cdna cloned cloning diencephalon differentiating fshbeta gland homeobox hybrid library lobe participating periods pituitary porcine pou primordium progenitor prop1 prrx2 retina rpf1 sequence transcripts upstream yeast	74146970t ab aggressive assessment bap1 carcinomas cdkn2a classification complement cyld delta facilitate indolent isoforms missense mutation next notably pbrm1 rarely recurrent sequencing stimulate subtype subtypes tets thymic thymomas tp53
Tagcloud (Intersection) ?