PELO and DYNLT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PELO	DYNLT1
Description		pelota mRNA surveillance and ribosome rescue factor	dynein light chain Tctex-type 1
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GO Annotations	Cellular Component	Cytoplasm Cytosolic Ribosome Dom34-Hbs1 Complex	Extracellular Region Cytoplasm Golgi Apparatus Spindle Cytoskeleton Cytoplasmic Dynein Complex Microtubule Cytoplasmic Microtubule Dynein Complex Secretory Granule Lumen Host Cell Secretory Vesicle Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Ribosome Binding Metal Ion Binding Nucleoside-triphosphatase Regulator Activity Stalled Ribosome Sensor Activity	Protein Binding Identical Protein Binding Dynein Intermediate Chain Binding
	Biological Process	Inner Cell Mass Cell Proliferation Regulation Of Translation Endoderm Development Stem Cell Population Maintenance Positive Regulation Of BMP Signaling Pathway Ribosome Disassembly Chromosome Organization Cell Division Mesenchymal To Epithelial Transition Nuclear-transcribed MRNA Catabolic Process, Non-stop Decay Nonfunctional RRNA Decay Nuclear-transcribed MRNA Catabolic Process, No-go Decay RNA Surveillance Rescue Of Stalled Ribosome	Establishment Of Mitotic Spindle Orientation Microtubule-based Movement Nervous System Development Regulation Of G Protein-coupled Receptor Signaling Pathway Intracellular Transport Of Viral Protein In Host Cell Positive Regulation Of Intracellular Transport Symbiont Entry Into Host Cell Negative Regulation Of Neurogenesis Cell Division Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Transport Of Viral Material Towards Nucleus
Pathways		PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	Neutrophil degranulation
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Birth weight ( 31043758) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Presence of antiphospholipid antibodies ( 23509613) Response to platinum-based agents ( 22020760) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Serum total protein levels ( 29403010) Systolic blood pressure ( 27841878) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		13 interacting genes: DYNLT1 FLNA HBS1L HSPB1 KRTAP12-2 LMO3 LMO4 MEOX2 PIK3R3 PRMT6 PTEN TRIM55 TRIM63	48 interacting genes: ACOX2 ACTN1 APP ARID4B BAG3 BMPR2 CCDC68 DDX54 DHX33 DNAJA2 DOC2A DOC2B DVL1 DVL2 DYNC1I1 DYNC1I2 FXR2 HAVCR1 HSPB7 HSPB9 ILF2 KIF2A KLK15 LNX1 NHSL2 NTAQ1 NUP153 NUP62 OLFM3 PELO PITX2 PSMA1 PTGES3L-AARSD1 PTH2R PVR RAD21 RBM14 RRAGA SDCBP SIRPA SVIL TCEANC TROAP TUBA3C TXN UXT VDAC1 XRN2
Entrez ID		53918	6993
HPRD ID		09309	15987
Ensembl ID		ENSG00000152684	ENSG00000146425
Uniprot IDs		Q9BRX2	P63172
PDB IDs		1X52 5EO3 5LZW 5LZX 5LZY 5LZZ	5JPW 8J07 8PR0 8PR1 8PTK 8RGI
Enriched GO Terms of Interacting Partners?		Contractile Muscle Fiber Regulation Of Cell Motility Regulation Of Cell Migration Regulation Of Locomotion Z Disc Negative Regulation Of Catabolic Process Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Platelet Aggregation DNA-binding Transcription Factor Binding Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Homotypic Cell-cell Adhesion Negative Regulation Of Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Kinase C Signaling Negative Regulation Of Nerve Growth Factor Production Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Dibasic Protein Processing Zymogen Inhibition Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Response To Electrical Stimulus Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Transport Of Viral Material Towards Nucleus Intracellular Transport Of Viral Protein In Host Cell Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Dom34-Hbs1 Complex Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Cell Communication Protein Localization To Cell Junction Fc-gamma Receptor I Complex Binding Tubulin Deacetylation Regulation Of Signaling Myb Complex Protein Kinase C Inhibitor Activity Negative Regulation Of Receptor Catabolic Process	Aggresome Chemical Synaptic Transmission Frizzled Binding Trans-synaptic Signaling Synaptic Signaling Synapse PTB Domain Binding Convergent Extension Involved In Neural Plate Elongation Microtubule-based Process Outflow Tract Morphogenesis Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cytoplasm Presynapse Regulation Of JNK Cascade Amyloid Fibril Formation Convergent Extension Involved In Organogenesis Regulation Of Spontaneous Synaptic Transmission Spindle Pole Convergent Extension Involved In Gastrulation Aggresome Assembly Spontaneous Neurotransmitter Secretion Synaptic Vesicle Exocytosis Positive Regulation Of Cellular Component Organization Transport Along Microtubule Vesicle-mediated Transport In Synapse Dynein Light Chain Binding Neurotransmitter Transport Positive Regulation Of Neuron Projection Arborization Neurotransmitter Secretion Protein-folding Chaperone Binding Cellular Response To Manganese Ion Regulated Exocytosis Regulation Of Exocytosis Centriolar Subdistal Appendage Inclusion Body Assembly Cytoskeleton-dependent Intracellular Transport Negative Regulation Of Transport Apoptotic Process Hsp70 Protein Binding Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Type 2 Mitophagy Cell-cell Signaling Microtubule-based Transport Programmed Cell Death Cell Death Microtubule Convergent Extension Calcium-dependent Activation Of Synaptic Vesicle Fusion Microtubule Motor Activity Response To Manganese Ion
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