PELO and HBS1L

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		PELO	HBS1L
Description		pelota mRNA surveillance and ribosome rescue factor	HBS1 like translational GTPase
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GO Annotations	Cellular Component	Cytoplasm Cytosolic Ribosome Dom34-Hbs1 Complex	Cytoplasm Cytosol Membrane Cytosolic Ribosome Extracellular Exosome Dom34-Hbs1 Complex
	Molecular Function	Protein Binding Ribosome Binding Metal Ion Binding Nucleoside-triphosphatase Regulator Activity Stalled Ribosome Sensor Activity	Nucleotide Binding Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Hydrolase Activity
	Biological Process	Inner Cell Mass Cell Proliferation Regulation Of Translation Endoderm Development Stem Cell Population Maintenance Positive Regulation Of BMP Signaling Pathway Ribosome Disassembly Chromosome Organization Cell Division Mesenchymal To Epithelial Transition Nuclear-transcribed MRNA Catabolic Process, Non-stop Decay Nonfunctional RRNA Decay Nuclear-transcribed MRNA Catabolic Process, No-go Decay RNA Surveillance Rescue Of Stalled Ribosome	Translation Translational Elongation Regulation Of Translation Signal Transduction Negative Regulation Of Gene Expression Ribosome Disassembly Nuclear-transcribed MRNA Catabolic Process, No-go Decay Rescue Of Stalled Ribosome
Pathways		PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	mRNA decay by 3' to 5' exoribonuclease
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Birth weight ( 31043758) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Presence of antiphospholipid antibodies ( 23509613) Response to platinum-based agents ( 22020760) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Serum total protein levels ( 29403010) Systolic blood pressure ( 27841878) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 29403010 33339817 33547301) Beta thalassemia/hemoglobin E disease ( 20183929) Cholesterol, total ( 24097068) Eosinophil count ( 27863252 29403010 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Fetal hemoglobin levels in sickle cell anemia ( 25372704) Glycated hemoglobin levels ( 24647736 29483669 34059833) Granulocyte count ( 27863252) HbA2 levels ( 23043469) Hematocrit ( 19862010 27863252 28017375 29403010 32888494) Hematological and biochemical traits ( 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863) Hemoglobin ( 29403010 32888494) Hemoglobin A1c levels ( 29403010) Hemoglobin concentration ( 27863252) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Hodgkin's lymphoma ( 24149102) Immature fraction of reticulocytes ( 32888494) Iron status biomarkers (iron levels) ( 33536631) Iron status biomarkers (total iron binding capacity) ( 33536631) Iron status biomarkers (transferrin saturation) ( 33536631) LDL cholesterol ( 30275531) LDL cholesterol levels ( 28334899 32203549) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 19853236 19862010 20139978 23263863 27863252 28017375 28031487 28453575 28548082 29403010 32888494) Mean corpuscular hemoglobin concentration ( 20139978 23263863 27863252 28017375 29403010 32888494) Mean corpuscular volume ( 19853236 19862010 20139978 23263863 27863252 28017375 28031487 28453575 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 27863252 32888494) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Myeloproliferative neoplasms ( 25849990) Neutrophil count ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Other erythrocyte phenotypes ( 19862010) Platelet count ( 19853236 20139978 22139419 22423221 24026423 26805783 27863252 28031487 29066854 29403010 32888494 33545615) Plateletcrit ( 27863252 32888494) Red blood cell count ( 20139978 27863252 28017375 28031487 28453575 29403010 32888494) Red blood cell traits ( 20927387 23222517 23935956) Red cell distribution width ( 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Spleen volume ( 34128465) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total cholesterol levels ( 28334899 30275531) White blood cell count ( 20139978 27863252 29403010 32888494) White blood cell types ( 21738478)
Interacting Genes		13 interacting genes: DYNLT1 FLNA HBS1L HSPB1 KRTAP12-2 LMO3 LMO4 MEOX2 PIK3R3 PRMT6 PTEN TRIM55 TRIM63	8 interacting genes: APP EXOSC9 MAP3K1 PELO SRPK1 SRPK2 UBC UBE2G2
Entrez ID		53918	10767
HPRD ID		09309	06582
Ensembl ID		ENSG00000152684	ENSG00000112339
Uniprot IDs		Q9BRX2	B7Z524 D9YZV0 Q9Y450
PDB IDs		1X52 5EO3 5LZW 5LZX 5LZY 5LZZ	5LZW 5LZX 5LZY 5LZZ 9G8M 9G8N 9G8O 9G8P 9G8R
Enriched GO Terms of Interacting Partners?		Contractile Muscle Fiber Regulation Of Cell Motility Regulation Of Cell Migration Regulation Of Locomotion Z Disc Negative Regulation Of Catabolic Process Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Platelet Aggregation DNA-binding Transcription Factor Binding Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Homotypic Cell-cell Adhesion Negative Regulation Of Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Kinase C Signaling Negative Regulation Of Nerve Growth Factor Production Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Dibasic Protein Processing Zymogen Inhibition Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Response To Electrical Stimulus Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Transport Of Viral Material Towards Nucleus Intracellular Transport Of Viral Protein In Host Cell Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Dom34-Hbs1 Complex Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Cell Communication Protein Localization To Cell Junction Fc-gamma Receptor I Complex Binding Tubulin Deacetylation Regulation Of Signaling Myb Complex Protein Kinase C Inhibitor Activity Negative Regulation Of Receptor Catabolic Process	Macromolecule Metabolic Process RRNA Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Protein Metabolic Process Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein Modification Process Phosphorylation Protein Phosphorylation Protein Serine Kinase Activity RNA Surveillance MRNA Metabolic Process Regulation Of Viral Genome Replication Spliceosomal Complex Assembly Negative Regulation Of Viral Process Negative Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Positive Regulation Of Viral Genome Replication Nucleoside-triphosphatase Regulator Activity Nuclear-transcribed MRNA Catabolic Process, Non-stop Decay Nonfunctional RRNA Decay Protein Serine/threonine Kinase Activity Macromolecule Catabolic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Immune Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Protein Kinase Activity U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process Regulation Of Viral Life Cycle Regulation Of MRNA Splicing, Via Spliceosome Dom34-Hbs1 Complex MRNA Catabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus
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