PELO

Description		pelota mRNA surveillance and ribosome rescue factor
Image
GO Annotations	Cellular Component	Cytoplasm Cytosolic Ribosome Dom34-Hbs1 Complex
	Molecular Function	Protein Binding Ribosome Binding Metal Ion Binding Nucleoside-triphosphatase Regulator Activity Stalled Ribosome Sensor Activity
	Biological Process	Inner Cell Mass Cell Proliferation Regulation Of Translation Endoderm Development Stem Cell Population Maintenance Positive Regulation Of BMP Signaling Pathway Ribosome Disassembly Chromosome Organization Cell Division Mesenchymal To Epithelial Transition Nuclear-transcribed MRNA Catabolic Process, Non-stop Decay Nonfunctional RRNA Decay Nuclear-transcribed MRNA Catabolic Process, No-go Decay RNA Surveillance Rescue Of Stalled Ribosome
Pathways		PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Birth weight ( 31043758) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Presence of antiphospholipid antibodies ( 23509613) Response to platinum-based agents ( 22020760) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Serum total protein levels ( 29403010) Systolic blood pressure ( 27841878) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Novel Interacting Genes		1 novel interacting genes: FURIN
Interacting Genes		13 interacting genes: DYNLT1 FLNA HBS1L HSPB1 KRTAP12-2 LMO3 LMO4 MEOX2 PIK3R3 PRMT6 PTEN TRIM55 TRIM63
Entrez ID		53918
HPRD ID		09309
Ensembl ID		ENSG00000152684
Uniprot IDs		Q9BRX2
PDB IDs		1X52 5EO3 5LZW 5LZX 5LZY 5LZZ
Enriched GO Terms of Interacting Partners?		Contractile Muscle Fiber Regulation Of Cell Motility Regulation Of Cell Migration Regulation Of Locomotion Z Disc Negative Regulation Of Catabolic Process Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Platelet Aggregation DNA-binding Transcription Factor Binding Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Homotypic Cell-cell Adhesion Negative Regulation Of Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Kinase C Signaling Negative Regulation Of Nerve Growth Factor Production Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Dibasic Protein Processing Zymogen Inhibition Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Response To Electrical Stimulus Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Transport Of Viral Material Towards Nucleus Intracellular Transport Of Viral Protein In Host Cell Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Dom34-Hbs1 Complex Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Cell Communication Protein Localization To Cell Junction Fc-gamma Receptor I Complex Binding Tubulin Deacetylation Regulation Of Signaling Myb Complex Protein Kinase C Inhibitor Activity Negative Regulation Of Receptor Catabolic Process
Tagcloud ?