CERS4 and -

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CERS4	-
Description		ceramide synthase 4	small integral membrane protein 11B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	DNA Binding Protein Binding Transferase Activity Sphingosine N-acyltransferase Activity
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process
Pathways		Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Macular telangiectasia type 2 ( 33654266) Mean reticulocyte volume ( 32888494) Metabolite levels ( 31628463) Red cell distribution width ( 32888494) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352) Sphingomyelin levels ( 31551469) Thyroid stimulating hormone levels ( 30367059 32769997) Very long-chain saturated fatty acid levels (fatty acid 24:0) ( 25378659)	HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)
Interacting Genes		47 interacting genes: - C1QL4 CCL4L2 CLEC1A COL4A5 CTXN3 CXCL16 CYB5R3 EMD FATE1 FCER1G FXYD6 FXYD6-FXYD2 GPR151 IER3IP1 IGFBP5 ITGAM JAGN1 LHFPL5 MS4A1 NAT8 NEU1 PLP2 PNLIPRP1 PTPN9 SCAMP5 SCD SERF1A SERF1B SERP2 SLC13A4 SLC29A2 SLC35A1 SLC35F6 SLC7A1 SMIM11 STX7 STX8 TEX264 TMEM119 TMEM176A TMEM254 TMEM72 TOMM6 TSPO2 UPK1B VAMP2	3 interacting genes: ASPH CERS4 UBQLN2
Entrez ID		79603	102723553
HPRD ID		13962
Ensembl ID		ENSG00000090661	ENSG00000273590
Uniprot IDs		Q53HF9 Q9HA82
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Amyloid Fibril Formation Endoplasmic Reticulum Membrane Endoplasmic Reticulum Regulation Of Exocytosis SNAP Receptor Activity Chloride Channel Inhibitor Activity Membrane Organization Positive Regulation Of Regulated Secretory Pathway SNARE Complex Syntaxin Binding Regulation Of Regulated Secretory Pathway Regulation Of Cellular Localization Regulation Of Protein Localization SNARE Binding	Positive Regulation Of Proteolysis Activation Of Store-operated Calcium Channel Activity Peptidyl-aspartic Acid 3-dioxygenase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of G Protein-coupled Receptor Internalization Sphingosine N-acyltransferase Activity Regulation Of Proteolysis Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Lumen Junctional Sarcoplasmic Reticulum Membrane Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cell Communication By Electrical Coupling Detection Of Calcium Ion Negative Regulation Of Receptor Internalization Positive Regulation Of ERAD Pathway Regulation Of Clathrin-dependent Endocytosis Regulation Of Calcium Ion Transport Into Cytosol Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Positive Regulation Of Cation Channel Activity Regulation Of ERAD Pathway
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