CERS4 and CLEC1A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CERS4	CLEC1A
Description		ceramide synthase 4	C-type lectin domain family 1 member A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Plasma Membrane Membrane
	Molecular Function	DNA Binding Protein Binding Transferase Activity Sphingosine N-acyltransferase Activity	Transmembrane Signaling Receptor Activity Protein Binding Carbohydrate Binding
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process	Signal Transduction Cell Surface Receptor Signaling Pathway
Pathways		Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Macular telangiectasia type 2 ( 33654266) Mean reticulocyte volume ( 32888494) Metabolite levels ( 31628463) Red cell distribution width ( 32888494) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352) Sphingomyelin levels ( 31551469) Thyroid stimulating hormone levels ( 30367059 32769997) Very long-chain saturated fatty acid levels (fatty acid 24:0) ( 25378659)	Metabolite levels ( 23823483)
Interacting Genes		47 interacting genes: - C1QL4 CCL4L2 CLEC1A COL4A5 CTXN3 CXCL16 CYB5R3 EMD FATE1 FCER1G FXYD6 FXYD6-FXYD2 GPR151 IER3IP1 IGFBP5 ITGAM JAGN1 LHFPL5 MS4A1 NAT8 NEU1 PLP2 PNLIPRP1 PTPN9 SCAMP5 SCD SERF1A SERF1B SERP2 SLC13A4 SLC29A2 SLC35A1 SLC35F6 SLC7A1 SMIM11 STX7 STX8 TEX264 TMEM119 TMEM176A TMEM254 TMEM72 TOMM6 TSPO2 UPK1B VAMP2	14 interacting genes: CERS4 CLEC12A FFAR2 FNDC9 GJA8 GPR152 GPX8 LMNA LRRC25 LRRC4C MRPS18B RNF19B STX1A TRAM1L1
Entrez ID		79603	51267
HPRD ID		13962	09489
Ensembl ID		ENSG00000090661	ENSG00000150048
Uniprot IDs		Q53HF9 Q9HA82	B3KRP6 B4DV89 E7ESV9 E9PFB4 Q8NC01
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Amyloid Fibril Formation Endoplasmic Reticulum Membrane Endoplasmic Reticulum Regulation Of Exocytosis SNAP Receptor Activity Chloride Channel Inhibitor Activity Membrane Organization Positive Regulation Of Regulated Secretory Pathway SNARE Complex Syntaxin Binding Regulation Of Regulated Secretory Pathway Regulation Of Cellular Localization Regulation Of Protein Localization SNARE Binding
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