CERS4 and SERF1B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CERS4	SERF1B
Description		ceramide synthase 4	small EDRK-rich factor 1B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Nucleus Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	DNA Binding Protein Binding Transferase Activity Sphingosine N-acyltransferase Activity	Protein Binding
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process	Nervous System Development Protein Destabilization Amyloid Fibril Formation
Pathways		Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Macular telangiectasia type 2 ( 33654266) Mean reticulocyte volume ( 32888494) Metabolite levels ( 31628463) Red cell distribution width ( 32888494) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352) Sphingomyelin levels ( 31551469) Thyroid stimulating hormone levels ( 30367059 32769997) Very long-chain saturated fatty acid levels (fatty acid 24:0) ( 25378659)
Interacting Genes		47 interacting genes: - C1QL4 CCL4L2 CLEC1A COL4A5 CTXN3 CXCL16 CYB5R3 EMD FATE1 FCER1G FXYD6 FXYD6-FXYD2 GPR151 IER3IP1 IGFBP5 ITGAM JAGN1 LHFPL5 MS4A1 NAT8 NEU1 PLP2 PNLIPRP1 PTPN9 SCAMP5 SCD SERF1A SERF1B SERP2 SLC13A4 SLC29A2 SLC35A1 SLC35F6 SLC7A1 SMIM11 STX7 STX8 TEX264 TMEM119 TMEM176A TMEM254 TMEM72 TOMM6 TSPO2 UPK1B VAMP2	12 interacting genes: ABHD16A AQP6 CERS4 CRB3 ELOVL4 ELOVL7 GPR152 REEP4 RNASEK TIMMDC1 TMEM14B TMX2
Entrez ID		79603	728492
HPRD ID		13962
Ensembl ID		ENSG00000090661	ENSG00000205572
Uniprot IDs		Q53HF9 Q9HA82	O75920
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Amyloid Fibril Formation Endoplasmic Reticulum Membrane Endoplasmic Reticulum Regulation Of Exocytosis SNAP Receptor Activity Chloride Channel Inhibitor Activity Membrane Organization Positive Regulation Of Regulated Secretory Pathway SNARE Complex Syntaxin Binding Regulation Of Regulated Secretory Pathway Regulation Of Cellular Localization Regulation Of Protein Localization SNARE Binding	Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Fatty Acid Elongation, Saturated Fatty Acid Membrane Fatty Acid Derivative Metabolic Process Very Long-chain Fatty Acid Biosynthetic Process Fatty Acid Elongation Sphingolipid Biosynthetic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Amide Biosynthetic Process Long-chain Fatty-acyl-CoA Metabolic Process Sphingolipid Metabolic Process Fatty-acyl-CoA Biosynthetic Process Mitochondrial Membrane Very Long-chain Fatty Acid Metabolic Process Membrane Lipid Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Endoplasmic Reticulum Membrane Fatty Acid Derivative Biosynthetic Process Nitrate Transmembrane Transporter Activity PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Acyl-CoA Metabolic Process Unsaturated Fatty Acid Metabolic Process Sulfur Compound Biosynthetic Process Subapical Complex Endoplasmic Reticulum Fatty Acid Biosynthetic Process Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Monoacylglycerol Catabolic Process Sphingosine N-acyltransferase Activity Lipid Metabolic Process Lipid Biosynthetic Process Monoatomic Anion Channel Activity Renal Water Transport Ammonium Channel Activity Disulfide Oxidoreductase Activity Ammonium Transmembrane Transport Mitotic Nuclear Membrane Reassembly Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V0 Domain G Protein-coupled Photoreceptor Activity Monoacylglycerol Lipase Activity Receptor-mediated Endocytosis Of Virus By Host Cell Water Channel Activity Endosomal Lumen Acidification
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