LAMA3 and PLAT

Number of citations of the paper that reports this interaction (PMID 10956663)
8

Data Source:
HPRD (in vitro)

		LAMA3	PLAT
Gene Name		laminin, alpha 3	plasminogen activator, tissue
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-1 Complex Laminin-5 Complex Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Cytoplasm Cell Surface Secretory Granule Extracellular Matrix Apical Part Of Cell Synapse Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Structural Molecule Activity	Serine-type Endopeptidase Activity Protein Binding
	Biological Process	Cell Adhesion Epidermis Development Extracellular Matrix Disassembly Regulation Of Cell Adhesion Extracellular Matrix Organization Regulation Of Cell Migration Hemidesmosome Assembly Cell Junction Assembly Endodermal Cell Differentiation Regulation Of Embryonic Development	Response To Hypoxia Cellular Protein Modification Process Proteolysis Blood Coagulation Smooth Muscle Cell Migration Plasminogen Activation Synaptic Transmission, Glutamatergic Fibrinolysis Response To Peptide Hormone Negative Regulation Of Proteolysis Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Synaptic Plasticity Response To CAMP Transmembrane Transport Positive Regulation Of Ovulation Cellular Response To Dexamethasone Stimulus
Pathways		Cell junction organization Type I hemidesmosome assembly Collagen formation Laminin interactions ECM proteoglycans Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures	Signaling by PDGF Dissolution of Fibrin Clot Orphan transporters
Drugs			Urokinase Aminocaproic Acid Ibuprofen Iloprost 6-Amino Hexanoic Acid 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID
Diseases
GWAS		Amyotrophic lateral sclerosis ( 22959728)
Protein-Protein Interactions		7 interactors: APC BMP1 LAMB3 PLAT PLG SDC2 SLC35E1	25 interactors: ANXA2 CALR CKAP4 CLEC3B F10 FGA FN1 GRIN1 HMGB1 KRT8 LAMA1 LAMA3 LAMA5 LRP1 LRP1B MAPK1 MAPK3 PDGFC PLAU PLG SERPINA5 SERPINE1 SERPING1 SERPINI1 SPARC
Entrez ID		3909	5327
HPRD ID		02883	01419
Ensembl ID		ENSG00000053747	ENSG00000104368
Uniprot IDs		B0YJ33 Q16787	B4DN26 B4DNJ1 P00750
PDB IDs			1A5H 1BDA 1PK2 1PML 1RTF 1TPG 1TPK 1TPM 1TPN
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Muscle Cell Cellular Homeostasis Fibrinolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Locomotion Regulation Of Blood Coagulation Movement Of Cell Or Subcellular Component Proteolysis Wound Healing Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Wound Healing Response To Wounding Tissue Development Positive Regulation Of Ovulation Mononuclear Cell Migration Cell Differentiation Response To Purine-containing Compound Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Odontogenesis Positive Regulation Of Fibrinolysis Cell Migration Cell Junction Assembly Cell Motility Metaphase/anaphase Transition Of Mitotic Cell Cycle Plasminogen Activation Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Epidermis Development Anatomical Structure Morphogenesis Negative Regulation Of Fibrinolysis Response To Hypoxia Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Microtubule Polymerization Hemidesmosome Assembly Positive Regulation Of Pseudopodium Assembly Regulation Of Fibrinolysis Negative Regulation Of Proteolysis Multicellular Organismal Development Negative Regulation Of Protein Processing Anatomical Structure Development Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Protein Processing Trophoblast Giant Cell Differentiation Regulation Of Attachment Of Spindle Microtubules To Kinetochore Blood Coagulation Hemostasis Response To Caffeine	Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Negative Regulation Of Blood Coagulation Fibrinolysis Wound Healing Negative Regulation Of Coagulation Platelet Activation Negative Regulation Of Wound Healing Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Regulation Of Cell Migration Regulation Of Blood Coagulation Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Wound Healing Vesicle-mediated Transport Cardiovascular System Development Regulation Of Cell Adhesion Multicellular Organismal Development Developmental Process Cell Activation System Development Anatomical Structure Development Blood Vessel Development Regulation Of Protein Metabolic Process Vasculature Development Regulation Of Vesicle-mediated Transport Regulation Of Catalytic Activity Response To Stress Exocytosis Regulation Of Cellular Component Organization Anatomical Structure Morphogenesis Regulation Of Cellular Protein Metabolic Process Receptor-mediated Endocytosis Response To Stimulus Regulation Of Cell-substrate Adhesion Locomotion Secretion Regulation Of Peptidase Activity Extracellular Matrix Disassembly Blood Vessel Morphogenesis Regulation Of Smooth Muscle Cell-matrix Adhesion Response To External Stimulus Regulation Of Golgi Inheritance Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component
Tagcloud ?		23h1 aberrations birc5 ccne2 ctsb dab2 ddx15 dismal egr1 etv4 eya4 gata3 gltscr2 hmmr itgb4 kcnk12 licam2 loxl2 metastasize mmp13 mpnst mpnsts msh2 pdgfra rassf2 rhamm sult2a1 tff top2a	10th 9th abundantly african crab cterminus eating evolutionary exonization exons harbor hominoids intriguingly intron l3 l3b marmoset monkey monkeys primate prosimian ran rhesus te tes transposable varies world zranb2
Tagcloud (Difference) ?		23h1 aberrations birc5 ccne2 ctsb dab2 ddx15 dismal egr1 etv4 eya4 gata3 gltscr2 hmmr itgb4 kcnk12 licam2 loxl2 metastasize mmp13 mpnst mpnsts msh2 pdgfra rassf2 rhamm sult2a1 tff top2a	10th 9th abundantly african crab cterminus eating evolutionary exonization exons harbor hominoids intriguingly intron l3 l3b marmoset monkey monkeys primate prosimian ran rhesus te tes transposable varies world zranb2
Tagcloud (Intersection) ?