LAMA3 and LAMB3

Number of citations of the paper that reports this interaction (PMID 7775432)
10

Data Source:
HPRD (in vitro)

		LAMA3	LAMB3
Gene Name		laminin, alpha 3	laminin, beta 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-1 Complex Laminin-5 Complex Extracellular Vesicular Exosome	Extracellular Region Laminin-5 Complex
	Molecular Function	Receptor Binding Structural Molecule Activity	Structural Molecule Activity Protein Binding Protein Complex Binding
	Biological Process	Cell Adhesion Epidermis Development Extracellular Matrix Disassembly Regulation Of Cell Adhesion Extracellular Matrix Organization Regulation Of Cell Migration Hemidesmosome Assembly Cell Junction Assembly Endodermal Cell Differentiation Regulation Of Embryonic Development	Cell Adhesion Epidermis Development Extracellular Matrix Disassembly Extracellular Matrix Organization Hemidesmosome Assembly Cell Junction Assembly Endodermal Cell Differentiation Brown Fat Cell Differentiation
Pathways		Cell junction organization Type I hemidesmosome assembly Collagen formation Laminin interactions ECM proteoglycans Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures	Cell junction organization Type I hemidesmosome assembly Collagen formation Laminin interactions Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 22959728)
Protein-Protein Interactions		7 interactors: APC BMP1 LAMB3 PLAT PLG SDC2 SLC35E1	5 interactors: BMP1 COL7A1 LAMA3 LAMC2 THBS1
Entrez ID		3909	3914
HPRD ID		02883	01032
Ensembl ID		ENSG00000053747	ENSG00000196878
Uniprot IDs		B0YJ33 Q16787	Q13751
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Muscle Cell Cellular Homeostasis Fibrinolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Locomotion Regulation Of Blood Coagulation Movement Of Cell Or Subcellular Component Proteolysis Wound Healing Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Wound Healing Response To Wounding Tissue Development Positive Regulation Of Ovulation Mononuclear Cell Migration Cell Differentiation Response To Purine-containing Compound Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Odontogenesis Positive Regulation Of Fibrinolysis Cell Migration Cell Junction Assembly Cell Motility Metaphase/anaphase Transition Of Mitotic Cell Cycle Plasminogen Activation Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Epidermis Development Anatomical Structure Morphogenesis Negative Regulation Of Fibrinolysis Response To Hypoxia Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Microtubule Polymerization Hemidesmosome Assembly Positive Regulation Of Pseudopodium Assembly Regulation Of Fibrinolysis Negative Regulation Of Proteolysis Multicellular Organismal Development Negative Regulation Of Protein Processing Anatomical Structure Development Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Protein Processing Trophoblast Giant Cell Differentiation Regulation Of Attachment Of Spindle Microtubules To Kinetochore Blood Coagulation Hemostasis Response To Caffeine	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Tissue Development Hemidesmosome Assembly Epidermis Development Endodermal Cell Differentiation Cell Adhesion Cell-substrate Junction Assembly Endoderm Formation Endoderm Development Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Formation Of Primary Germ Layer Anatomical Structure Development Anatomical Structure Morphogenesis Engulfment Of Apoptotic Cell Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Gastrulation Cartilage Development Developmental Process Cell Junction Assembly Negative Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Nitric Oxide Mediated Signal Transduction Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Anatomical Structure Formation Involved In Morphogenesis Epithelium Development Negative Regulation Of Antigen Processing And Presentation Connective Tissue Development Regulation Of CGMP-mediated Signaling Negative Regulation Of Endopeptidase Activity Skeletal System Morphogenesis Negative Regulation Of Peptidase Activity Positive Regulation Of Macrophage Chemotaxis Negative Regulation Of Plasminogen Activation Positive Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Fibrinolysis Negative Regulation Of Proteolysis Positive Regulation Of Fibroblast Migration Protein O-linked Fucosylation Positive Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Protein Processing Positive Regulation Of Macrophage Activation Regulation Of Endopeptidase Activity Cellular Response To Nitric Oxide Negative Regulation Of Hydrolase Activity Chronic Inflammatory Response Phagocytosis, Engulfment Regulation Of Fibrinolysis Regulation Of Protein Processing
Tagcloud ?		23h1 aberrations birc5 ccne2 ctsb dab2 ddx15 dismal egr1 etv4 eya4 gata3 gltscr2 hmmr itgb4 kcnk12 licam2 loxl2 metastasize mmp13 mpnst mpnsts msh2 pdgfra rassf2 rhamm sult2a1 tff top2a	besides built c13orf18 ccl3 cish clustering comprising cytoreductive discriminators et fosb gadd45b granulocytes hrh4 id2 jak jak2v617f klf5 maff mutational pim1 signature socs2 socs3 stat supervised tagap thrombocythemia trib1
Tagcloud (Difference) ?		23h1 aberrations birc5 ccne2 ctsb dab2 ddx15 dismal egr1 etv4 eya4 gata3 gltscr2 hmmr itgb4 kcnk12 licam2 loxl2 metastasize mmp13 mpnst mpnsts msh2 pdgfra rassf2 rhamm sult2a1 tff top2a	besides built c13orf18 ccl3 cish clustering comprising cytoreductive discriminators et fosb gadd45b granulocytes hrh4 id2 jak jak2v617f klf5 maff mutational pim1 signature socs2 socs3 stat supervised tagap thrombocythemia trib1
Tagcloud (Intersection) ?