LAMA3 and BMP1

Number of citations: 0 (PubMedID 10806203)
Data Source: HPRD (in vitro, in vivo)

		LAMA3	BMP1
Name		laminin subunit alpha 3	bone morphogenetic protein 1
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-3 Complex Laminin-5 Complex Endoplasmic Reticulum Adherens Junction Hemidesmosome Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Golgi Apparatus Vesicle
	Molecular Function	Signaling Receptor Binding Structural Molecule Activity Extracellular Matrix Structural Constituent	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Cytokine Activity Calcium Ion Binding Protein Binding Growth Factor Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Cell Adhesion Epidermis Development Anatomical Structure Morphogenesis Regulation Of Cell Adhesion Regulation Of Cell Migration Hemidesmosome Assembly Endodermal Cell Differentiation Regulation Of Embryonic Development Cell-cell Adhesion	Skeletal System Development Cartilage Condensation Ossification Proteolysis Signal Transduction Dorsal/ventral Pattern Formation Protein Processing Cell Differentiation Collagen Fibril Organization Cartilage Development Positive Regulation Of Cartilage Development
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Anchoring fibril formation Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Type I hemidesmosome assembly MET activates PTK2 signaling Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells	Degradation of the extracellular matrix Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils
Drugs		Lanoteplase	None
Diseases		Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA) Laryngoonychocutaneous syndrome Epidermolysis bullosa, hemidesmosomal, including: Epidermolysis bullosa, generalized atrophic benign (GABEB); Epidermolysis bullosa simplex with pyloric atresia (EBS-PA); Epidermolysis bullosa simplex with muscular dystrophy (EBS-MD); Epidermolysis bullosa simplex, Ogna type (EBS-Ogna)	None
GWAS		Allergic rhinitis ( 25085501 ) Amyotrophic lateral sclerosis ( 22959728 ) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107 ) High light scatter reticulocyte count ( 27863252 ) High light scatter reticulocyte percentage of red cells ( 27863252 )	Coronary artery disease ( 29212778 ) Hypertriglyceridemia ( 23505323 ) Myocardial infarction ( 33532862 ) Waist-to-hip ratio adjusted for BMI ( 28552196 )
Interacting Genes		7 interacting genes: APC BMP1 LAMB3 PLAT PLG SDC2 SLC35E1	14 interacting genes: ADRA1A CHRD COL1A1 COL5A1 COL5A2 COL7A1 GEM HSPG2 LAMA3 LAMB3 LAMC2 TP53 TWSG1 YLPM1
Entrez ID		3909	649
HPRD ID		02883	00209
Ensembl ID		ENSG00000053747	ENSG00000168487
Uniprot IDs		A0A0A0MSA0 A0A0A0MTS5 A0A0A6YYF2 Q16787	P13497
PDB IDs		Not available	3EDG 3EDH 6BSL 6BSM 6BTN 6BTO 6BTP 6BTQ
GO Terms Enriched among Interactors		Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Trans-synaptic Signaling By BDNF Extracellular Matrix Negative Regulation Of Fibrinolysis Trans-synaptic Signaling, Modulating Synaptic Transmission Serine-type Endopeptidase Activity Regulation Of Fibrinolysis Fibrinolysis Protein Processing Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Protein Maturation Cell Migration Positive Regulation Of Wound Healing Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Cell Motility Peptidase Activity Proteolysis Schaffer Collateral - CA1 Synapse Blood Coagulation Coagulation Hemostasis Serine-type Peptidase Activity Laminin-5 Complex Regulation Of Wound Healing Cell Surface Positive Regulation Of Fibrinolysis Cellular Developmental Process Prevention Of Polyspermy Regulation Of Response To Wounding Serine Protease Inhibitor Complex Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Localization To Centrosome Negative Regulation Of Plasminogen Activation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Antigen Binding Leading Edge Membrane Extracellular Structure Organization Extracellular Matrix Organization Regulation Of Fertilization Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Cyclin-dependent Protein Kinase Activity Plasminogen Activation Beta-catenin Destruction Complex Gamma-catenin Binding	Basement Membrane Extracellular Matrix Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Fibrillar Collagen Trimer Extracellular Region Tissue Development Collagen Trimer Collagen Type V Trimer Negative Regulation Of Endodermal Cell Differentiation Laminin-5 Complex Endodermal Cell Differentiation Collagen Type XI Trimer Epidermis Development Hemidesmosome Assembly Integrin Binding Skin Development Hemidesmosome Collagen Fibril Organization Regulation Of Developmental Process Platelet-derived Growth Factor Binding Collagen Biosynthetic Process Cell Adhesion Protease Binding Response To Xenobiotic Stimulus Microtubule Plus-end Binding Endoplasmic Reticulum Lumen Developmental Process Microtubule Plus-end Negative Regulation Of Developmental Process Animal Organ Development Anatomical Structure Morphogenesis System Development Extracellular Space Negative Regulation Of Cell Differentiation Heparin Binding Regulation Of Cell Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell-substrate Junction Assembly Cell Cortex Structural Molecule Activity Cell-substrate Junction Organization Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Cell Population Proliferation Cellular Response To Vitamin E Skeletal System Development Integrin Biosynthetic Process Collagen Type VII Trimer Regulation Of Myelination