LAMA3 and SLC35E1

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid)

		LAMA3	SLC35E1
Name		laminin subunit alpha 3	solute carrier family 35 member E1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-3 Complex Laminin-5 Complex Endoplasmic Reticulum Adherens Junction Hemidesmosome Extracellular Matrix Extracellular Exosome	Golgi Apparatus Membrane
	Molecular Function	Signaling Receptor Binding Structural Molecule Activity Extracellular Matrix Structural Constituent	Protein Binding Antiporter Activity
	Biological Process	Cell Adhesion Epidermis Development Anatomical Structure Morphogenesis Regulation Of Cell Adhesion Regulation Of Cell Migration Hemidesmosome Assembly Endodermal Cell Differentiation Regulation Of Embryonic Development Cell-cell Adhesion	Transmembrane Transport
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Anchoring fibril formation Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Type I hemidesmosome assembly MET activates PTK2 signaling Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells	None
Drugs		Lanoteplase	None
Diseases		Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA) Laryngoonychocutaneous syndrome Epidermolysis bullosa, hemidesmosomal, including: Epidermolysis bullosa, generalized atrophic benign (GABEB); Epidermolysis bullosa simplex with pyloric atresia (EBS-PA); Epidermolysis bullosa simplex with muscular dystrophy (EBS-MD); Epidermolysis bullosa simplex, Ogna type (EBS-Ogna)	None
GWAS		Allergic rhinitis ( 25085501 ) Amyotrophic lateral sclerosis ( 22959728 ) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107 ) High light scatter reticulocyte count ( 27863252 ) High light scatter reticulocyte percentage of red cells ( 27863252 )	No GWAS studies recorded
Interacting Genes		7 interacting genes: APC BMP1 LAMB3 PLAT PLG SDC2 SLC35E1	6 interacting genes: ABCF3 FTHL17 FXYD6 LAMA3 MCOLN1 MPP1
Entrez ID		3909	79939
HPRD ID		02883	15373
Ensembl ID		ENSG00000053747	ENSG00000127526
Uniprot IDs		A0A0A0MSA0 A0A0A0MTS5 A0A0A6YYF2 Q16787	Q96K37
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Trans-synaptic Signaling By BDNF Extracellular Matrix Negative Regulation Of Fibrinolysis Trans-synaptic Signaling, Modulating Synaptic Transmission Serine-type Endopeptidase Activity Regulation Of Fibrinolysis Fibrinolysis Protein Processing Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Protein Maturation Cell Migration Positive Regulation Of Wound Healing Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Cell Motility Peptidase Activity Proteolysis Schaffer Collateral - CA1 Synapse Blood Coagulation Coagulation Hemostasis Serine-type Peptidase Activity Laminin-5 Complex Regulation Of Wound Healing Cell Surface Positive Regulation Of Fibrinolysis Cellular Developmental Process Prevention Of Polyspermy Regulation Of Response To Wounding Serine Protease Inhibitor Complex Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Localization To Centrosome Negative Regulation Of Plasminogen Activation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Antigen Binding Leading Edge Membrane Extracellular Structure Organization Extracellular Matrix Organization Regulation Of Fertilization Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Cyclin-dependent Protein Kinase Activity Plasminogen Activation Beta-catenin Destruction Complex Gamma-catenin Binding	Laminin-5 Complex Hemidesmosome Assembly Hemidesmosome Laminin-3 Complex Monoatomic Cation Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane Potassium Ion Transport Metal Ion Transport Sodium Ion Transport Ion Channel Regulator Activity Iron Ion Transport Ferric Iron Binding Positive Regulation Of Lysosome Organization Monoatomic Anion Channel Activity Intracellularly Phosphatidylinositol-3,5-bisphosphate-gated Monatomic Cation Channel Activity Calcium Ion Export Ligand-gated Calcium Channel Activity NAADP-sensitive Calcium-release Channel Activity Iron Ion Transmembrane Transporter Activity Procollagen Galactosyltransferase Activity Positive Regulation Of Collagen Fibril Organization GMP Kinase Activity Regulation Of Collagen Fibril Organization GDP Metabolic Process Monoatomic Ion Transport Transferrin Transport Phagosome Maturation