LAMA3 and APC

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		LAMA3	APC
Gene Name		laminin, alpha 3	adenomatous polyposis coli
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-1 Complex Laminin-5 Complex Extracellular Vesicular Exosome	Kinetochore Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoplasmic Microtubule Plasma Membrane Cell-cell Adherens Junction Tight Junction Lateral Plasma Membrane Lamellipodium Beta-catenin Destruction Complex Ruffle Membrane Microtubule Plus-end Axonal Growth Cone
	Molecular Function	Receptor Binding Structural Molecule Activity	Protein Binding Beta-catenin Binding Microtubule Binding Protein Kinase Regulator Activity Protein Kinase Binding Gamma-catenin Binding Cadherin Binding Microtubule Plus-end Binding
	Biological Process	Cell Adhesion Epidermis Development Extracellular Matrix Disassembly Regulation Of Cell Adhesion Extracellular Matrix Organization Regulation Of Cell Migration Hemidesmosome Assembly Cell Junction Assembly Endodermal Cell Differentiation Regulation Of Embryonic Development	Mitotic Cytokinesis Kidney Development Hair Follicle Development Protein Complex Assembly Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cellular Response To DNA Damage Stimulus Negative Regulation Of Microtubule Depolymerization Cell Cycle Arrest Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Cell Adhesion Axonogenesis Negative Regulation Of Cell Proliferation Axis Specification Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Epithelial Cell Differentiation Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Positive Regulation Of Pseudopodium Assembly Regulation Of Microtubule-based Process T Cell Differentiation In Thymus Somatic Stem Cell Maintenance Negative Regulation Of Odontogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Osteoblast Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Adhesion Muscle Cell Cellular Homeostasis Thymus Development Regulation Of Nitrogen Compound Metabolic Process Chromosome Organization Positive Regulation Of Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Retina Development In Camera-type Eye Canonical Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Tight Junction Assembly Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Cell junction organization Type I hemidesmosome assembly Collagen formation Laminin interactions ECM proteoglycans Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures	misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN Programmed Cell Death Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex Apoptotic cleavage of cellular proteins misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Apoptotic execution phase phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 22959728)
Protein-Protein Interactions		7 interactors: APC BMP1 LAMB3 PLAT PLG SDC2 SLC35E1	109 interactors: ACTN1 AGFG1 ANKRD17 ANXA7 AP2B1 ARHGEF4 AXIN1 AXIN2 BUB1 BUB1B C4A CGNL1 COG4 COG5 CREBBP CSNK1A1 CSNK1E CSNK2A1 CTBP1 CTNNA1 CTNNB1 CYTH2 DLG3 DLGAP1 DST EPAS1 ERBB2IP EXPH5 FAM214A FBXO30 FHOD1 FLNA GIGYF2 GOLGA2 GSK3B HGS HNRNPM HSPA5 HTRA2 ING5 IQGAP1 JUP KIAA1328 KIF5B KIFAP3 KRT13 KRT14 KRT15 KRT17 KRT19 KRT23 KRT5 LAMA3 LAMA4 LPHN1 MACF1 MAPRE1 MAPRE2 MBD5 MCM3AP MUC1 MYH10 MYH11 MYO6 NAV1 NAV2 NAV3 NCKAP5 NCKAP5L ND4 NEB NOSTRIN NUP153 NUP214 NUP54 NUP98 NUPL1 NUPL2 PNISR POM121 POM121C PPP1R13B PPP2CA PPP2R5A PRKACA PSMD1 PTPN13 RANBP9 RBM4B RP1 RPS27 SCRIB SEC31A SETDB1 SIAH1 SMC3 SNRNP200 SPECC1L SPTBN1 SPTBN2 SYNE1 TAF1 TFAP2A TPR TRIM21 TUBA4A XPO1 YWHAQ ZNF106
Entrez ID		3909	324
HPRD ID		02883	01439
Ensembl ID		ENSG00000053747	ENSG00000134982
Uniprot IDs		B0YJ33 Q16787	B7Z2B6 P25054 Q4LE70
PDB IDs			1DEB 1EMU 1JPP 1M5I 1T08 1TH1 1V18 2RQU 3AU3 3NMW 3NMX 3NMZ 3QHE 3RL7 3RL8 3T7U 4G69
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Muscle Cell Cellular Homeostasis Fibrinolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Locomotion Regulation Of Blood Coagulation Movement Of Cell Or Subcellular Component Proteolysis Wound Healing Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Wound Healing Response To Wounding Tissue Development Positive Regulation Of Ovulation Mononuclear Cell Migration Cell Differentiation Response To Purine-containing Compound Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Odontogenesis Positive Regulation Of Fibrinolysis Cell Migration Cell Junction Assembly Cell Motility Metaphase/anaphase Transition Of Mitotic Cell Cycle Plasminogen Activation Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Epidermis Development Anatomical Structure Morphogenesis Negative Regulation Of Fibrinolysis Response To Hypoxia Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Microtubule Polymerization Hemidesmosome Assembly Positive Regulation Of Pseudopodium Assembly Regulation Of Fibrinolysis Negative Regulation Of Proteolysis Multicellular Organismal Development Negative Regulation Of Protein Processing Anatomical Structure Development Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Protein Processing Trophoblast Giant Cell Differentiation Regulation Of Attachment Of Spindle Microtubules To Kinetochore Blood Coagulation Hemostasis Response To Caffeine	Cell Cycle Mitotic Cell Cycle Organelle Organization Mitotic Cell Cycle Process Protein Localization Cell Cycle Process Cellular Localization Mitotic Nuclear Envelope Disassembly Cellular Protein Localization Establishment Of Localization In Cell MRNA Transport Nuclear Envelope Disassembly Nucleus Organization Nuclear Envelope Organization Endomembrane System Organization RNA Transport Membrane Organization Viral Process RNA Localization Cellular Component Assembly Nucleocytoplasmic Transport Nuclear Transport Response To Stimulus Signaling Intracellular Transport Cell Communication Signal Transduction Regulation Of Cellular Component Organization Establishment Of Protein Localization Cytoplasmic Transport Anatomical Structure Development Cytoskeleton Organization Regulation Of Cell Cycle Viral Transcription Cell Differentiation Regulation Of Glucose Transport Protein Transport Developmental Process Viral Life Cycle Regulation Of Protein Catabolic Process Glucose Transport Cell Development Positive Regulation Of Wnt Signaling Pathway Hexose Transport Cellular Response To Stimulus Protein Localization To Organelle Negative Regulation Of Cell Cycle Regulation Of Signal Transduction Regulation Of Cellular Process Cell Junction Assembly
Tagcloud ?		23h1 aberrations birc5 ccne2 ctsb dab2 ddx15 dismal egr1 etv4 eya4 gata3 gltscr2 hmmr itgb4 kcnk12 licam2 loxl2 metastasize mmp13 mpnst mpnsts msh2 pdgfra rassf2 rhamm sult2a1 tff top2a	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Difference) ?		23h1 aberrations birc5 ccne2 ctsb dab2 ddx15 dismal egr1 etv4 eya4 gata3 gltscr2 hmmr itgb4 kcnk12 licam2 loxl2 metastasize mmp13 mpnst mpnsts msh2 pdgfra rassf2 rhamm sult2a1 tff top2a	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Intersection) ?