SPTA1 and TSHZ2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SPTA1	TSHZ2
Name		spectrin alpha, erythrocytic 1	teashirt zinc finger homeobox 2
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin Cytoplasmic Side Of Plasma Membrane Spectrin-associated Cytoskeleton Actin Cytoskeleton Membrane Cell Junction Axon Cortical Cytoskeleton Cortical Actin Cytoskeleton Cuticular Plate Cell Projection	Chromatin Nucleus
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Metal Ion Binding Actin Filament Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Lymphocyte Homeostasis Porphyrin-containing Compound Biosynthetic Process Plasma Membrane Organization Actin Filament Organization Regulation Of Cell Shape Actin Cytoskeleton Organization Hemopoiesis Positive Regulation Of T Cell Proliferation Actin Filament Capping	Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression
Pathways		NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport	None
Diseases		Hereditary spherocytosis (SPH) Hereditary elliptocytosis (HE)	None
GWAS		Glycated hemoglobin levels ( 20858683 34059833 28898252 ) Heel bone mineral density x serum urate levels interaction ( 34046847 ) Hemoglobin A1c levels ( 29844224 ) Hemoglobin levels ( 32327693 ) hemolysis of donated blood (osmotic) ( 34014839 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 32888494 27863252 ) Lymphocyte count ( 32888494 27863252 ) Lymphocyte percentage of white cells ( 32888494 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular hemoglobin concentration ( 27863252 32888494 29403010 ) Mean corpuscular volume ( 32888494 29403010 27863252 ) Mean platelet volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte count ( 32888494 ) Neutrophil percentage of white cells ( 32888494 27863252 ) Night sleep phenotypes ( 27126917 ) Other erythrocyte phenotypes ( 19862010 ) Platelet distribution width ( 32888494 ) QRS duration ( 27577874 ) Red blood cell count ( 32888494 ) Red blood cell traits ( 23222517 ) Red cell distribution width ( 28957414 32888494 27863252 ) Reticulocyte count ( 32888494 27863252 ) Reticulocyte fraction of red cells ( 27863252 32888494 ) White blood cell count ( 32888494 )	A body shape index ( 34021172 ) Adventurousness ( 30643258 ) Age at first sexual intercourse ( 34211149 ) Alcohol consumption (max-drinks) ( 29460428 ) Apolipoprotein A1 levels ( 32203549 ) Asthma ( 30929738 ) Asthma (childhood onset) ( 30929738 ) Coronary artery aneurysm in Kawasaki disease ( 27171184 ) Crohn's disease ( 32581322 ) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) General risk tolerance (MTAG) ( 30643258 ) Hemoglobin ( 19862010 ) Hip index ( 34021172 ) Parkinson's disease ( 26227905 ) Spatial memory ( 31596458 ) Triglyceride levels ( 32203549 ) Triglyceride levels x loop diuretics use interaction ( 31806883 ) Type 2 diabetes ( 30297969 ) Type 2 diabetes (age of onset) ( 28060188 ) Urinary metabolite levels in chronic kidney disease ( 29545352 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		27 interacting genes: ABI1 ABL1 ACTA1 ADD1 ANK1 BCKDK C21orf58 CCDC185 CIMAP1B DGCR6L ENAH EVL EXOSC5 FANCC FASLG GADD45GIP1 KRT75 PKP2 PLEC SLC9A2 SPTB SPTBN2 TSHZ2 TXN2 VASP YWHAQ ZNF326	21 interacting genes: APBB1 BACH2 CCDC57 CCDC88B CNTROB COG3 CRACR2B GIGYF1 GOLGA2 GRIPAP1 MCC PHAF1 PIBF1 PNMA1 RABEP1 RINT1 SPTA1 TFIP11 TRAF1 TRAF2 UBE2I
Entrez ID		6708	128553
HPRD ID		01685	10730
Ensembl ID		ENSG00000163554	ENSG00000182463
Uniprot IDs		P02549	Q9NRE2
PDB IDs		1OWA 3LBX 5J4O	Not available
GO Terms Enriched among Interactors		Supramolecular Fiber Organization Actin Filament Organization Actin Polymerization Or Depolymerization Structural Constituent Of Cytoskeleton Profilin Binding Cytoskeleton Regulation Of Actin Filament-based Process Cytoskeleton Organization Regulation Of Actin Filament Polymerization Actin Binding Regulation Of Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Filopodium Cadherin Binding Lamellipodium Regulation Of Actin Cytoskeleton Organization Actin Filament Binding Actin Cytoskeleton Organization Actin Filament Capping Regulation Of Supramolecular Fiber Organization SH3 Domain Binding Negative Regulation Of Actin Filament Depolymerization Actin Filament-based Process Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Size Focal Adhesion Negative Regulation Of Actin Filament Polymerization Spectrin-associated Cytoskeleton Regulation Of Actin Filament Depolymerization Spectrin Regulation Of Cytoskeleton Organization Intermediate Filament Organization Negative Regulation Of Protein-containing Complex Disassembly Cell Junction Regulation Of Protein Depolymerization Intermediate Filament Cytoskeleton Organization Ankyrin Binding Intermediate Filament-based Process Postsynapse Regulation Of Postsynaptic Specialization Assembly Cell Projection Cytoskeletal Anchor Activity Spectrin Binding Actin Cytoskeleton Skeletal Muscle Fiber Development Regulation Of Protein-containing Complex Disassembly Cellular Response To Fluid Shear Stress Myotube Cell Development Negative Regulation Of Protein-containing Complex Assembly	Golgi Vesicle Transport Thioesterase Binding Microtubule Organizing Center Organization Cytoplasm Cellular Localization Microtubule Nucleation Establishment Of Protein Localization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Membraneless Organelle Assembly Tumor Necrosis Factor Receptor Binding Centriole Assembly Centriole Replication