SPTA1 and SLC9A2

Number of citations of the paper that reports this interaction (PMID 10187839)
2

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		SPTA1	SLC9A2
Gene Name		spectrin, alpha, erythrocytic 1	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Spectrin Spectrin-associated Cytoskeleton Actin Cytoskeleton Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Cuticular Plate	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Protein Heterodimerization Activity Actin Filament Binding	Sodium:proton Antiporter Activity
	Biological Process	Lymphocyte Homeostasis Porphyrin-containing Compound Biosynthetic Process Plasma Membrane Organization Actin Filament Organization Axon Guidance Regulation Of Cell Shape Hemopoiesis Positive Regulation Of Protein Binding Positive Regulation Of T Cell Proliferation Actin Filament Capping	Ion Transport Regulation Of PH Protein Localization Sodium Ion Transmembrane Transport Transmembrane Transport Hydrogen Ion Transmembrane Transport
Pathways		Interaction between L1 and Ankyrins Axon guidance L1CAM interactions NCAM signaling for neurite out-growth	Sodium/Proton exchangers Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport
Drugs
Diseases
GWAS		Glycated hemoglobin levels ( 20858683) Other erythrocyte phenotypes ( 19862010) Red blood cell traits ( 23222517)
Protein-Protein Interactions		16 interactors: ABI1 ABL1 ACTA1 ADD1 ANK1 ENAH EVL FANCC FASLG PLEC SLC9A2 SPTB SPTBN2 UBC VASP YWHAQ	8 interactors: ABL1 CHP1 CHP2 PIK3R1 RASA1 SPTA1 SPTAN1 SRC
Entrez ID		6708	6549
HPRD ID		01685	02756
Ensembl ID		ENSG00000163554	ENSG00000115616
Uniprot IDs		P02549	Q9UBY0
PDB IDs		1OWA 3LBX
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Cell Development Axon Guidance Cell Morphogenesis Immune System Process Cell Projection Morphogenesis Axonogenesis Cell Part Morphogenesis Anatomical Structure Morphogenesis Axon Development Regulation Of Organelle Organization Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Actin Cytoskeleton Organization Cell Differentiation Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Neuron Projection Morphogenesis Actin Filament-based Process Movement Of Cell Or Subcellular Component Regulation Of Actin Filament-based Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Cell Morphogenesis Involved In Differentiation Cytoskeleton Organization Cell Projection Organization Actin Polymerization Or Depolymerization Anatomical Structure Development Neuron Projection Development Regulation Of Cytoskeleton Organization Response To External Stimulus System Development Immune Response-activating Cell Surface Receptor Signaling Pathway Neuron Development Developmental Process Regulation Of Cellular Component Size Antigen Receptor-mediated Signaling Pathway Regulation Of Protein Complex Assembly Multicellular Organismal Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Organ Development Neuron Differentiation Actin Filament Capping Locomotion Negative Regulation Of Actin Filament Depolymerization Immune Response-regulating Signaling Pathway Cellular Component Assembly Regulation Of Cellular Component Organization Regulation Of Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization	Positive Regulation Of Protein Transport Axon Guidance Regulation Of Organelle Organization Regulation Of Intracellular Transport Negative Regulation Of Cell-matrix Adhesion Regulation Of Cellular Component Organization Regulation Of Cytoskeleton Organization Axonogenesis Negative Regulation Of Cell Adhesion Axon Development Negative Regulation Of Cell-substrate Adhesion Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Locomotion Regulation Of Cell Adhesion Regulation Of Protein Transport Positive Regulation Of Intracellular Transport Neuron Projection Morphogenesis Regulation Of Establishment Of Protein Localization Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Movement Of Cell Or Subcellular Component Regulation Of Protein Localization Neuron Projection Development Regulation Of Protein Complex Assembly Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Actin Cytoskeleton Organization Regulation Of Cell-cell Adhesion Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Development Regulation Of Actin Filament-based Process Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Intracellular Signal Transduction Regulation Of Cell-matrix Adhesion Transcytosis Regulation Of Cellular Localization Cell Morphogenesis Negative Regulation Of Protein Complex Assembly Neuron Differentiation Cell Projection Organization Response To Acidic PH Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Import Into Nucleus Regulation Of Actin Filament Polymerization
Tagcloud ?		ank1 antiglobulin appointment bilirubin cared cytoskeletal cytoskeleton damaged delays discharged e508k epb41 epb42 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spherocytes sptb ugt1a1	actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom ezr fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures vwf
Tagcloud (Difference) ?		ank1 antiglobulin appointment bilirubin cared cytoskeletal cytoskeleton damaged delays discharged e508k epb41 epb42 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spherocytes sptb ugt1a1	actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom ezr fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures vwf
Tagcloud (Intersection) ?