SPTA1 and CIMAP1B

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SPTA1	CIMAP1B
Name		spectrin alpha, erythrocytic 1	ciliary microtubule associated protein 1B
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin Cytoplasmic Side Of Plasma Membrane Spectrin-associated Cytoskeleton Actin Cytoskeleton Membrane Cell Junction Axon Cortical Cytoskeleton Cortical Actin Cytoskeleton Cuticular Plate Cell Projection	Cytoskeleton Cilium Motile Cilium Cell Projection
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Metal Ion Binding Actin Filament Binding	Protein Binding
	Biological Process	Lymphocyte Homeostasis Porphyrin-containing Compound Biosynthetic Process Plasma Membrane Organization Actin Filament Organization Regulation Of Cell Shape Actin Cytoskeleton Organization Hemopoiesis Positive Regulation Of T Cell Proliferation Actin Filament Capping	None
Pathways		NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport	None
Diseases		Hereditary spherocytosis (SPH) Hereditary elliptocytosis (HE)	None
GWAS		Glycated hemoglobin levels ( 20858683 34059833 28898252 ) Heel bone mineral density x serum urate levels interaction ( 34046847 ) Hemoglobin A1c levels ( 29844224 ) Hemoglobin levels ( 32327693 ) hemolysis of donated blood (osmotic) ( 34014839 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 32888494 27863252 ) Lymphocyte count ( 32888494 27863252 ) Lymphocyte percentage of white cells ( 32888494 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular hemoglobin concentration ( 27863252 32888494 29403010 ) Mean corpuscular volume ( 32888494 29403010 27863252 ) Mean platelet volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte count ( 32888494 ) Neutrophil percentage of white cells ( 32888494 27863252 ) Night sleep phenotypes ( 27126917 ) Other erythrocyte phenotypes ( 19862010 ) Platelet distribution width ( 32888494 ) QRS duration ( 27577874 ) Red blood cell count ( 32888494 ) Red blood cell traits ( 23222517 ) Red cell distribution width ( 28957414 32888494 27863252 ) Reticulocyte count ( 32888494 27863252 ) Reticulocyte fraction of red cells ( 27863252 32888494 ) White blood cell count ( 32888494 )	No GWAS studies recorded
Interacting Genes		27 interacting genes: ABI1 ABL1 ACTA1 ADD1 ANK1 BCKDK C21orf58 CCDC185 CIMAP1B DGCR6L ENAH EVL EXOSC5 FANCC FASLG GADD45GIP1 KRT75 PKP2 PLEC SLC9A2 SPTB SPTBN2 TSHZ2 TXN2 VASP YWHAQ ZNF326	8 interacting genes: ACTN2 ACTN3 FHL3 HSF2BP KRTAP3-3 MDFI MKRN3 SPTA1
Entrez ID		6708	440836
HPRD ID		01685	18640
Ensembl ID		ENSG00000163554	ENSG00000177989
Uniprot IDs		P02549	A0A8C8KQ56 A1L1A8 A8MYP8 B5MC17 B5MD02
PDB IDs		1OWA 3LBX 5J4O	Not available
GO Terms Enriched among Interactors		Supramolecular Fiber Organization Actin Filament Organization Actin Polymerization Or Depolymerization Structural Constituent Of Cytoskeleton Profilin Binding Cytoskeleton Regulation Of Actin Filament-based Process Cytoskeleton Organization Regulation Of Actin Filament Polymerization Actin Binding Regulation Of Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Filopodium Cadherin Binding Lamellipodium Regulation Of Actin Cytoskeleton Organization Actin Filament Binding Actin Cytoskeleton Organization Actin Filament Capping Regulation Of Supramolecular Fiber Organization SH3 Domain Binding Negative Regulation Of Actin Filament Depolymerization Actin Filament-based Process Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Size Focal Adhesion Negative Regulation Of Actin Filament Polymerization Spectrin-associated Cytoskeleton Regulation Of Actin Filament Depolymerization Spectrin Regulation Of Cytoskeleton Organization Intermediate Filament Organization Negative Regulation Of Protein-containing Complex Disassembly Cell Junction Regulation Of Protein Depolymerization Intermediate Filament Cytoskeleton Organization Ankyrin Binding Intermediate Filament-based Process Postsynapse Regulation Of Postsynaptic Specialization Assembly Cell Projection Cytoskeletal Anchor Activity Spectrin Binding Actin Cytoskeleton Skeletal Muscle Fiber Development Regulation Of Protein-containing Complex Disassembly Cellular Response To Fluid Shear Stress Myotube Cell Development Negative Regulation Of Protein-containing Complex Assembly	Cortical Actin Cytoskeleton Actin Filament-based Process Actin Binding Actin Cytoskeleton Organization Z Disc Pseudopodium Focal Adhesion Assembly Actin Filament Binding Cell Junction Cell-substrate Junction Assembly Cell-substrate Junction Organization Structural Constituent Of Muscle Regulation Of Actin Filament Depolymerization Actin Cytoskeleton Sarcomere Actin Filament Uncapping Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Titin Z Domain Binding Muscle Cell Development Cytoskeleton Organization Focal Adhesion Actin Filament Regulation Of Protein Depolymerization Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Interleukin-2 Receptor Complex Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Bone Mineralization Involved In Bone Maturation Interleukin-15 Receptor Activity Interleukin-2 Binding Interleukin-2 Receptor Activity Regulation Of Protein-containing Complex Disassembly Microspike Assembly Transmembrane Transporter Binding Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Integrin Binding FATZ Binding Positive Regulation Of Skeletal Muscle Tissue Growth Skeletal Muscle Atrophy Structural Constituent Of Postsynaptic Actin Cytoskeleton Channel Activator Activity Calcium Ion Binding LIM Domain Binding Negative Regulation Of Relaxation Of Muscle Response To Denervation Involved In Regulation Of Muscle Adaptation Transition Between Fast And Slow Fiber Regulation Of Skeletal Muscle Tissue Growth Skeletal Muscle Adaptation Striated Muscle Atrophy