SPTA1 and ENAH

Number of citations of the paper that reports this interaction (PMID 16336193)
6

Data Source:
HPRD (two hybrid)

		SPTA1	ENAH
Gene Name		spectrin, alpha, erythrocytic 1	enabled homolog (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Cytosol Spectrin Spectrin-associated Cytoskeleton Actin Cytoskeleton Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Cuticular Plate	Stress Fiber Cytoplasm Cytosol Plasma Membrane Focal Adhesion Lamellipodium Cell Junction Filopodium Synapse
	Molecular Function	Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Protein Heterodimerization Activity Actin Filament Binding	Actin Binding Protein Binding SH3 Domain Binding WW Domain Binding
	Biological Process	Lymphocyte Homeostasis Porphyrin-containing Compound Biosynthetic Process Plasma Membrane Organization Actin Filament Organization Axon Guidance Regulation Of Cell Shape Hemopoiesis Positive Regulation Of Protein Binding Positive Regulation Of T Cell Proliferation Actin Filament Capping	Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Intracellular Transport T Cell Receptor Signaling Pathway
Pathways		Interaction between L1 and Ankyrins Axon guidance L1CAM interactions NCAM signaling for neurite out-growth	TCR signaling Generation of second messenger molecules Axon guidance Signaling by Robo receptor Adaptive Immune System
Drugs
Diseases
GWAS		Glycated hemoglobin levels ( 20858683) Other erythrocyte phenotypes ( 19862010) Red blood cell traits ( 23222517)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		16 interactors: ABI1 ABL1 ACTA1 ADD1 ANK1 ENAH EVL FANCC FASLG PLEC SLC9A2 SPTB SPTBN2 UBC VASP YWHAQ	20 interactors: ABI1 ABI2 ABI3 ABL1 APBB1 BAIAP2 DNMBP FAT1 FYB GPHN MAPK1 PFN1 PRPF40A ROBO4 SPTA1 TERF2IP TES WAS XIRP1 ZYX
Entrez ID		6708	55740
HPRD ID		01685	12360
Ensembl ID		ENSG00000163554	ENSG00000154380
Uniprot IDs		P02549	Q8N8S7
PDB IDs		1OWA 3LBX	2HO2 2IYB 2XQN
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Cell Development Axon Guidance Cell Morphogenesis Immune System Process Cell Projection Morphogenesis Axonogenesis Cell Part Morphogenesis Anatomical Structure Morphogenesis Axon Development Regulation Of Organelle Organization Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Actin Cytoskeleton Organization Cell Differentiation Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Neuron Projection Morphogenesis Actin Filament-based Process Movement Of Cell Or Subcellular Component Regulation Of Actin Filament-based Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Cell Morphogenesis Involved In Differentiation Cytoskeleton Organization Cell Projection Organization Actin Polymerization Or Depolymerization Anatomical Structure Development Neuron Projection Development Regulation Of Cytoskeleton Organization Response To External Stimulus System Development Immune Response-activating Cell Surface Receptor Signaling Pathway Neuron Development Developmental Process Regulation Of Cellular Component Size Antigen Receptor-mediated Signaling Pathway Regulation Of Protein Complex Assembly Multicellular Organismal Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Organ Development Neuron Differentiation Actin Filament Capping Locomotion Negative Regulation Of Actin Filament Depolymerization Immune Response-regulating Signaling Pathway Cellular Component Assembly Regulation Of Cellular Component Organization Regulation Of Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization	Actin Cytoskeleton Organization Actin Filament-based Process Actin Filament Organization Cytoskeleton Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Regulation Of Cytoskeleton Organization Organelle Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament-based Process Regulation Of Cellular Component Organization Immune Response-regulating Signaling Pathway Phagocytosis Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Anatomical Structure Morphogenesis Positive Regulation Of Immune Response Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Anatomical Structure Development Cell Projection Organization Actin Polymerization Or Depolymerization Neuron Projection Development Locomotion Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Immune Response Regulation Of Immune System Process Cell Development Axonogenesis Developmental Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Development Neuron Development Cell Morphogenesis Involved In Neuron Differentiation T Cell Receptor Signaling Pathway Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Cell Motility Neuron Projection Morphogenesis System Development Regulation Of Response To DNA Damage Stimulus Cell Morphogenesis Endocytosis Regulation Of Actin Nucleation
Tagcloud ?		ank1 antiglobulin appointment bilirubin cared cytoskeletal cytoskeleton damaged delays discharged e508k epb41 epb42 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spherocytes sptb ugt1a1	atf4 biomarkers chek2 computational concept conjunction datasets downregulated druggable eventually icoslg identifying implicate jimt methodology preclinical progress proof rad51 reproducibly restored rigorous rigorously skbr3 subpathways transcriptomic trastuzumab upregulated validation
Tagcloud (Difference) ?		ank1 antiglobulin appointment bilirubin cared cytoskeletal cytoskeleton damaged delays discharged e508k epb41 epb42 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spherocytes sptb ugt1a1	atf4 biomarkers chek2 computational concept conjunction datasets downregulated druggable eventually icoslg identifying implicate jimt methodology preclinical progress proof rad51 reproducibly restored rigorous rigorously skbr3 subpathways transcriptomic trastuzumab upregulated validation
Tagcloud (Intersection) ?