COL17A1 and PPL

Number of citations of the paper that reports this interaction (PubMedID 9521878)
0

Data Source:
HPRD (two hybrid)

		COL17A1	PPL
Description		collagen type XVII alpha 1 chain	periplakin
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GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Basement Membrane Endoplasmic Reticulum Lumen Plasma Membrane Cell-cell Junction Membrane Hemidesmosome Extracellular Matrix Anchoring Junction	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Membrane Desmosome Extracellular Exosome Anchoring Junction
	Molecular Function	Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding
	Biological Process	Cell-matrix Adhesion Epidermis Development Hemidesmosome Assembly	Response To Mechanical Stimulus Keratinization Wound Healing Intermediate Filament Cytoskeleton Organization
Pathways		Collagen degradation Collagen biosynthesis and modifying enzymes Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Type I hemidesmosome assembly Collagen chain trimerization	Formation of the cornified envelope Butyrophilin (BTN) family interactions
Drugs
Diseases		Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS		Cardiac hypertrophy ( 21348951)	Adult body size ( 32376654) Appendicular lean mass ( 33097823) Cancer ( 29299148) Diastolic blood pressure ( 27841878 28135244) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung cancer (asbestos exposure interaction) ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000) Mitochondrial DNA copy number (white blood cells) ( 30704525) Systolic blood pressure ( 27841878) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		18 interacting genes: ACTN1 ACTN4 CLSTN1 CSTF2T CTNND1 DSP DST ITGA6 ITGB4 KRT18 LAD1 PLEC PLOD3 PNKP PPIL1 PPL UBQLN2 WHRN	44 interacting genes: ACTR5 AHCYL1 AKT1 ALAS1 C6orf141 CASP6 CEP57L1 COL17A1 DES EVPL HECTD3 IKZF1 ITSN1 KAZN KCTD21 KNSTRN KRT25 KRT39 KRT8 MRPL28 OPRM1 PBX4 PICK1 PLEKHA7 POF1B PPHLN1 PTEN RAB3IP SKIL TRAF2 TRIM27 TSC22D4 UBC UPRT USP7 VIM WEE2-AS1 ZBTB26 ZNF165 ZNF213 ZNF263 ZNF474 ZSCAN1 ZSCAN16
Entrez ID		1308	5493
HPRD ID		00223	04187
Ensembl ID		ENSG00000065618	ENSG00000118898
Uniprot IDs		Q9UMD9	O60437
PDB IDs		8IZS	4Q28
Enriched GO Terms of Interacting Partners?		Cell-substrate Junction Organization Cell-substrate Junction Assembly Anchoring Junction Hemidesmosome Assembly Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Hemidesmosome Cell Junction Organization Cell-cell Adhesion Intermediate Filament Structural Molecule Activity Wound Healing Cell Adhesion Response To Wounding Focal Adhesion Cell Junction Assembly Extracellular Exosome Z Disc Neuregulin Binding Integrin Binding Cadherin Binding Nail Development Fascia Adherens Cytoskeleton Organization Skin Morphogenesis Insulin-like Growth Factor I Binding Stress Fiber Basement Membrane Muscle Cell Development Pseudopodium Cell Periphery Integrin-mediated Signaling Pathway Structural Constituent Of Cytoskeleton Myelination In Peripheral Nervous System Actin Cytoskeleton Integrin Complex Plasma Membrane Cytoskeleton Anatomical Structure Morphogenesis Desmosome Actin Binding Cell-cell Junction Organization Cell Morphogenesis Adherens Junction Negative Regulation Of Blood Vessel Branching Integrin Alpha6-beta4 Complex X11-like Protein Binding Actin Filament Binding Cell Junction Cell-cell Junction	Intermediate Filament Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Identical Protein Binding Intermediate Filament Cytoskeleton Cellular Response To Rapamycin TORC1 Signaling Intermediate Filament Organization Regulation Of RNA Metabolic Process TOR Signaling Desmosome Response To Rapamycin Cell-cell Junction PML Body Regulation Of Nucleobase-containing Compound Metabolic Process Protein Domain Specific Binding Cellular Response To Ether
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