COL17A1 and PPL

Number of citations of the paper that reports this interaction (PMID 9521878)
11

Data Source:
HPRD (two hybrid)

		COL17A1	PPL
Gene Name		collagen, type XVII, alpha 1	periplakin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Trimer Basement Membrane Endoplasmic Reticulum Lumen Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Hemidesmosome	Nucleus Mitochondrion Cytoskeleton Plasma Membrane Desmosome Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Cell-matrix Adhesion Epidermis Development Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Hemidesmosome Assembly Cell Junction Assembly	Keratinization
Pathways		Cell junction organization Type I hemidesmosome assembly Collagen formation Collagen degradation Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS		Cardiac hypertrophy ( 21348951)	Lung cancer-asbestos exposure interaction ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000)
Protein-Protein Interactions		12 interactors: ACTN1 ACTN4 CLSTN1 CTNND1 DSP DST ITGA6 ITGB4 KRT18 LAD1 PLEC PPL	22 interactors: AHCYL1 AKT1 ALAS1 CASP6 CEP57L1 COL17A1 EVPL ITSN1 KAZN KRT8 OPRM1 PPHLN1 RAB3IP RALBP1 SKIL TRAF2 TRIM27 TSC22D4 UBC USP7 VIM ZSCAN1
Entrez ID		1308	5493
HPRD ID		00223	04187
Ensembl ID		ENSG00000065618	ENSG00000118898
Uniprot IDs		Q9UMD9	O60437
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Junction Assembly Hemidesmosome Assembly Cell-substrate Junction Assembly Protein Localization To Cell Junction Protein Localization To Tight Junction Cell Adhesion Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cell-cell Junction Organization Skin Development Cellular Component Assembly Nail Development Adherens Junction Organization Integrin-mediated Signaling Pathway Amelogenesis Actin Crosslink Formation Filopodium Assembly Cell-matrix Adhesion Cytoskeleton Organization Cell-substrate Adhesion Wound Healing Tight Junction Assembly Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Actin Filament Bundle Assembly Platelet Degranulation Golgi To Plasma Membrane CFTR Protein Transport Apical Junction Assembly Execution Phase Of Apoptosis Keratinocyte Differentiation Blood Coagulation Hemostasis Ventricular Compact Myocardium Morphogenesis Odontogenesis Of Dentin-containing Tooth Cell-cell Junction Assembly Positive Regulation Of Pinocytosis Single Organismal Cell-cell Adhesion Odontogenesis Positive Regulation Of Sodium:proton Antiporter Activity Protein Localization To Adherens Junction Epidermal Cell Differentiation Digestive Tract Development Regulation Of Body Fluid Levels Digestive System Development Response To Stress Regulation Of Sodium:proton Antiporter Activity Ectodermal Cell Differentiation Peroxisome Proliferator Activated Receptor Signaling Pathway	Epithelial Cell Differentiation Epithelium Development Protein Trimerization Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Keratinization Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Execution Phase Of Apoptosis Keratinocyte Differentiation Tissue Development Epidermis Development Regulation Of Intracellular Signal Transduction Protein Homotrimerization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Response To Food Positive Regulation Of Cell Death Apoptotic Signaling Pathway Glycogen Biosynthetic Process Developmental Process Epidermal Cell Differentiation Response To Cytokine Tumor Necrosis Factor-mediated Signaling Pathway Cell Differentiation Involved In Embryonic Placenta Development Cell Differentiation Anatomical Structure Development Protein K63-linked Ubiquitination Lens Fiber Cell Differentiation Positive Regulation Of Sodium Ion Transport Protein Polyubiquitination Regulation Of Ion Transmembrane Transport Cellular Polysaccharide Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Polysaccharide Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Catalytic Activity Regulation Of Phosphorylation Negative Regulation Of Neuron Death Positive Regulation Of Phosphorylation Negative Regulation Of Ion Transmembrane Transport Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Organic Substance
Tagcloud ?		aligning alopecia atrophic blistering bullosa codons corrective correlating dystrophy enamel epidermolysis exons faulty harbouring herlitz hypoplasia introns jeb junctional milder mucous nail nh nonsense pitting premtrna repaired vicinity xvii	32p aug carboxyl codons dephosphorylation detergents digestion disposition doublet duck embo envelope ganem hepadnavirus hepadnaviruses immunoblots imply labelling morphogenesis myristic myristylation ostapchuk p35 phosphatases s1 s2 topological virion yielding
Tagcloud (Difference) ?		aligning alopecia atrophic blistering bullosa corrective correlating dystrophy enamel epidermolysis exons faulty harbouring herlitz hypoplasia introns jeb junctional milder mucous nail nh nonsense pitting premtrna repaired vicinity xvii	32p aug carboxyl dephosphorylation detergents digestion disposition doublet duck embo envelope ganem hepadnavirus hepadnaviruses immunoblots imply labelling morphogenesis myristic myristylation ostapchuk p35 phosphatases s1 s2 topological virion yielding
Tagcloud (Intersection) ?		codons