COL17A1 and ITGB4

Number of citations of the paper that reports this interaction (PubMedID 9660880)
85

Data Source:
HPRD (two hybrid, in vivo)

		COL17A1	ITGB4
Description		collagen type XVII alpha 1 chain	integrin subunit beta 4
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Basement Membrane Endoplasmic Reticulum Lumen Plasma Membrane Cell-cell Junction Membrane Hemidesmosome Extracellular Matrix Anchoring Junction	Basement Membrane Nucleolus Plasma Membrane Focal Adhesion Integrin Complex Basal Plasma Membrane Cell Surface Membrane Cell Junction Hemidesmosome Cell Leading Edge Nuclear Membrane Receptor Complex Extracellular Exosome Anchoring Junction
	Molecular Function	Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength	G Protein-coupled Receptor Binding Integrin Binding Protein Binding Insulin-like Growth Factor I Binding Neuregulin Binding Metal Ion Binding
	Biological Process	Cell-matrix Adhesion Epidermis Development Hemidesmosome Assembly	Autophagy Cell Communication Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Response To Wounding Cell Migration Myelination In Peripheral Nervous System Hemidesmosome Assembly Peripheral Nervous System Myelin Formation Cell Adhesion Mediated By Integrin Nail Development Skin Morphogenesis Filopodium Assembly Mesodermal Cell Differentiation Cell Motility Trophoblast Cell Migration Cell-cell Adhesion
Pathways		Collagen degradation Collagen biosynthesis and modifying enzymes Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Type I hemidesmosome assembly Collagen chain trimerization	Assembly of collagen fibrils and other multimeric structures Laminin interactions Syndecan interactions Type I hemidesmosome assembly Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs			R1295
Diseases		Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)	Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS		Cardiac hypertrophy ( 21348951)
Interacting Genes		18 interacting genes: ACTN1 ACTN4 CLSTN1 CSTF2T CTNND1 DSP DST ITGA6 ITGB4 KRT18 LAD1 PLEC PLOD3 PNKP PPIL1 PPL UBQLN2 WHRN	60 interacting genes: ADAMTSL4 ALOX12 APPBP2 ATXN1 CLCA1 CLCA2 COL17A1 CYSRT1 DST ECM1 EIF6 ERBB2 ERBIN FYN GRB2 HOXA1 ITGA6 KPRP KRT31 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP15-1 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP4-2 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 MDFI MET MID2 MTUS2 MYF5 NBPF19 NOTCH2NLA PLEC PLSCR4 POU2AF1 PRKCA PRKCD PTK2 SDC2 SDC3 SHC1 SREBF2 TGM1 TRIP6 VIM YES1 YWHAB YWHAQ
Entrez ID		1308	3691
HPRD ID		00223	00946
Ensembl ID		ENSG00000065618	ENSG00000132470
Uniprot IDs		Q9UMD9	B7ZLD8 P16144
PDB IDs		8IZS	1QG3 2YRZ 3F7P 3F7Q 3F7R 3FQ4 3FSO 3H6A 4Q58 4WTW 4WTX 6GVK 6GVL
Enriched GO Terms of Interacting Partners?		Cell-substrate Junction Organization Cell-substrate Junction Assembly Anchoring Junction Hemidesmosome Assembly Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Hemidesmosome Cell Junction Organization Cell-cell Adhesion Intermediate Filament Structural Molecule Activity Wound Healing Cell Adhesion Response To Wounding Focal Adhesion Cell Junction Assembly Extracellular Exosome Z Disc Neuregulin Binding Integrin Binding Cadherin Binding Nail Development Fascia Adherens Cytoskeleton Organization Skin Morphogenesis Insulin-like Growth Factor I Binding Stress Fiber Basement Membrane Muscle Cell Development Pseudopodium Cell Periphery Integrin-mediated Signaling Pathway Structural Constituent Of Cytoskeleton Myelination In Peripheral Nervous System Actin Cytoskeleton Integrin Complex Plasma Membrane Cytoskeleton Anatomical Structure Morphogenesis Desmosome Actin Binding Cell-cell Junction Organization Cell Morphogenesis Adherens Junction Negative Regulation Of Blood Vessel Branching Integrin Alpha6-beta4 Complex X11-like Protein Binding Actin Filament Binding Cell Junction Cell-cell Junction	Intermediate Filament Keratin Filament Identical Protein Binding Hemidesmosome Cytosol Establishment Of Skin Barrier Cell-substrate Junction Assembly Skin Epidermis Development Cell-substrate Junction Organization Epidermis Development Hemidesmosome Assembly Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Focal Adhesion Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane Protein Tyrosine Kinase Activity Fc-gamma Receptor Signaling Pathway ERBB Signaling Pathway Anchoring Junction Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Protein Kinase C Signaling Ephrin Receptor Binding Regulation Of Reactive Oxygen Species Metabolic Process Intermediate Filament Organization Regulation Of Platelet Aggregation Neurotrophin TRKA Receptor Binding Cell Junction Organization Insulin-like Growth Factor Receptor Signaling Pathway Cellular Response To Fluid Shear Stress Cell Junction Assembly Regulation Of Cell-cell Adhesion Integrin-mediated Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway CD4 Receptor Binding Immune Effector Process Structural Constituent Of Cytoskeleton Protein Binding Response To Fluid Shear Stress Enzyme Binding T Cell Costimulation Negative Regulation Of Glial Cell Apoptotic Process Phosphotyrosine Residue Binding Negative Regulation Of Platelet Aggregation Intermediate Filament Cytoskeleton Peptidyl-tyrosine Phosphorylation
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