COL17A1 and KRT18

Number of citations of the paper that reports this interaction (PMID 10022517)
4

Data Source:
HPRD (two hybrid, in vitro)

		COL17A1	KRT18
Gene Name		collagen, type XVII, alpha 1	keratin 18, type I
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Trimer Basement Membrane Endoplasmic Reticulum Lumen Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Hemidesmosome	Nucleolus Cytoplasm Microtubule Organizing Center Intermediate Filament Centriolar Satellite Keratin Filament Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Cell Periphery
	Molecular Function	Protein Binding	Structural Molecule Activity Protein Binding Poly(A) RNA Binding Scaffold Protein Binding
	Biological Process	Cell-matrix Adhesion Epidermis Development Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Hemidesmosome Assembly Cell Junction Assembly	Cell Cycle Anatomical Structure Morphogenesis Viral Process Tumor Necrosis Factor-mediated Signaling Pathway Golgi To Plasma Membrane CFTR Protein Transport Negative Regulation Of Apoptotic Process Intermediate Filament Cytoskeleton Organization Extrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process
Pathways		Cell junction organization Type I hemidesmosome assembly Collagen formation Collagen degradation Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS		Cardiac hypertrophy ( 21348951)
Protein-Protein Interactions		12 interactors: ACTN1 ACTN4 CLSTN1 CTNND1 DSP DST ITGA6 ITGB4 KRT18 LAD1 PLEC PPL	73 interactors: BBS1 BBS2 BBS4 BBS7 CAMK2A CASP3 CASP6 CASP7 CASP8 CBL CCDC146 CCDC85B CCNI CDC5L CDK1 COL17A1 DEDD DNAJB6 EGFR EP300 EXOC8 FRAT1 GIT2 GOLGA2 GRN HAUS1 HGS HRAS HSPA1A HSPA4 HSPA5 IKBKG KPNA2 KRT15 KRT5 KRT72 KRT8 LDOC1 MAPK14 NME7 ORC5 PDE4DIP PIAS4 PKD1 PKP2 PKP3 PNN POT1 PRKCA PRKCE RAF1 RHPN2 RPS6KA3 SERPINE1 SHC1 SMARCD1 SUMO1 SVIL TCHP TNFRSF1B TRADD TUBG1 TUBGCP4 TXN2 TXNDC11 UPF2 USH2A YTHDC1 YWHAB YWHAE YWHAG YWHAH YWHAZ
Entrez ID		1308	3875
HPRD ID		00223	01020
Ensembl ID		ENSG00000065618	ENSG00000111057
Uniprot IDs		Q9UMD9	P05783
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Junction Assembly Hemidesmosome Assembly Cell-substrate Junction Assembly Protein Localization To Cell Junction Protein Localization To Tight Junction Cell Adhesion Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cell-cell Junction Organization Skin Development Cellular Component Assembly Nail Development Adherens Junction Organization Integrin-mediated Signaling Pathway Amelogenesis Actin Crosslink Formation Filopodium Assembly Cell-matrix Adhesion Cytoskeleton Organization Cell-substrate Adhesion Wound Healing Tight Junction Assembly Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Actin Filament Bundle Assembly Platelet Degranulation Golgi To Plasma Membrane CFTR Protein Transport Apical Junction Assembly Execution Phase Of Apoptosis Keratinocyte Differentiation Blood Coagulation Hemostasis Ventricular Compact Myocardium Morphogenesis Odontogenesis Of Dentin-containing Tooth Cell-cell Junction Assembly Positive Regulation Of Pinocytosis Single Organismal Cell-cell Adhesion Odontogenesis Positive Regulation Of Sodium:proton Antiporter Activity Protein Localization To Adherens Junction Epidermal Cell Differentiation Digestive Tract Development Regulation Of Body Fluid Levels Digestive System Development Response To Stress Regulation Of Sodium:proton Antiporter Activity Ectodermal Cell Differentiation Peroxisome Proliferator Activated Receptor Signaling Pathway	Apoptotic Process Programmed Cell Death Cell Death Death Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Death Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Regulation Of Apoptotic Process Neurotrophin Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Cellular Response To Growth Factor Stimulus Response To Growth Factor Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway ERBB Signaling Pathway Cellular Component Assembly Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Communication Positive Regulation Of Cellular Protein Metabolic Process Membrane Organization Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Organelle Organization Innate Immune Response Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Transport Anatomical Structure Development Mitotic Cell Cycle Regulation Of Cellular Component Organization Regulation Of Signaling Mitotic Cell Cycle Phase Transition Cellular Response To Fibroblast Growth Factor Stimulus Cell Cycle Phase Transition Enzyme Linked Receptor Protein Signaling Pathway Response To Fibroblast Growth Factor Developmental Process Defense Response Regulation Of Proteolysis Cellular Protein Localization Cellular Response To Stimulus
Tagcloud ?		aligning alopecia atrophic blistering bullosa codons corrective correlating dystrophy enamel epidermolysis exons faulty harbouring herlitz hypoplasia introns jeb junctional milder mucous nail nh nonsense pitting premtrna repaired vicinity xvii	actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom ezr fsp1 genomelab hcellmarkerplex house hybridisation incorporates lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf
Tagcloud (Difference) ?		aligning alopecia atrophic blistering bullosa codons corrective correlating dystrophy enamel epidermolysis exons faulty harbouring herlitz hypoplasia introns jeb junctional milder mucous nail nh nonsense pitting premtrna repaired vicinity xvii	actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom ezr fsp1 genomelab hcellmarkerplex house hybridisation incorporates lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf
Tagcloud (Intersection) ?