PLD1 and STXBP1

Number of citations of the paper that reports this interaction (PubMedID 14744865)
0

Data Source:
HPRD (in vitro, in vivo)

		PLD1	STXBP1
Description		phospholipase D1	syntaxin binding protein 1
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Endomembrane System Membrane Apical Plasma Membrane Endocytic Vesicle Cytoplasmic Vesicle Late Endosome Membrane Organelle Subcompartment Specific Granule Membrane Perinuclear Region Of Cytoplasm Tertiary Granule Membrane Cholinergic Synapse	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Secretory Granule Axon Platelet Alpha Granule Protein-containing Complex Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Parallel Fiber To Purkinje Cell Synapse Presynapse Postsynapse Presynaptic Active Zone Cytoplasmic Component Extrinsic Component Of Presynaptic Membrane Glutamatergic Synapse Presynaptic Cytosol
	Molecular Function	Catalytic Activity Phospholipase D Activity Protein Binding Hydrolase Activity Phosphatidylinositol Binding	SNARE Binding RNA Binding Protein Binding Syntaxin-1 Binding Protein Kinase Binding Protein Domain Specific Binding Syntaxin Binding Identical Protein Binding Phospholipase Binding
	Biological Process	Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Chemotaxis Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Phospholipid Catabolic Process Lipid Catabolic Process Cellular Response To Nutrient Regulation Of Microvillus Assembly Intracellular Signal Transduction Positive Regulation Of Translation Regulation Of Vesicle-mediated Transport Regulation Of Synaptic Vesicle Cycle	Platelet Degranulation Developmental Process Involved In Reproduction Intracellular Protein Transport Exocytosis Vesicle Docking Involved In Exocytosis Neurotransmitter Secretion Neuromuscular Synaptic Transmission Axon Target Recognition Regulation Of Synaptic Vesicle Priming Protein Transport Synaptic Vesicle Priming Synaptic Vesicle Maturation Vesicle-mediated Transport Negative Regulation Of Protein-containing Complex Assembly Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Negative Regulation Of Synaptic Transmission, GABAergic Response To Estradiol SNARE Complex Assembly Regulation Of SNARE Complex Assembly Positive Regulation Of Mast Cell Degranulation Negative Regulation Of Neuron Apoptotic Process Regulated Exocytosis Positive Regulation Of Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Protein Stabilization Neuron Apoptotic Process Establishment Of Localization In Cell Long-term Synaptic Depression Platelet Aggregation Cellular Response To Type II Interferon Protein Localization To Plasma Membrane Presynaptic Dense Core Vesicle Exocytosis Positive Regulation Of Vesicle Docking Positive Regulation Of Glutamate Secretion, Neurotransmission Regulation Of Regulated Secretory Pathway Regulation Of Acrosomal Vesicle Exocytosis
Pathways		Synthesis of PG Synthesis of PA Role of phospholipids in phagocytosis Neutrophil degranulation RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle	Regulation of insulin secretion Neurexins and neuroligins
Drugs		Choline LAX-101 Choline salicylate
Diseases			Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Cerebrospinal fluid AB1-42 levels ( 29274321) Eosinophil count ( 32888494) Red cell distribution width ( 27863252 28957414 32888494) Reticulocyte fraction of red cells ( 32888494)	Body size at age 10 ( 32376654) Whole brain grey matter density ( 31530798)
Interacting Genes		28 interacting genes: ACTA1 ACTB ACTG1 ARF1 ARF6 ARIH1 ARL11 ARL14 BIN1 CAV1 CDC42 EGFR EGLN1 HIF1A PEA15 PIP5K1A PKN1 PKN3 PRKCA RAC1 RALA RHEB RHOA RHOG SNCA SRC STXBP1 VHL	35 interacting genes: APBA1 APBA2 APP BRME1 CDK5 CDK5R1 CENPP DOC2A DOC2B HGS MAPK1 MAPT MEOX2 MTDH MTNR1A NEFH NEFM PLD1 PLD2 PRKCA PRKCB PRKCG RIPPLY3 SPICE1 SPTBN1 SQSTM1 STX1A STX1B STX2 STX3 STX5 SYTL4 TRIM38 TTC3 USO1
Entrez ID		5337	6812
HPRD ID		03855	04235
Ensembl ID		ENSG00000075651	ENSG00000136854
Uniprot IDs		Q13393 Q59EA4	A0A0D9SG72 A0A1B0GTP9 A0A1B0GVQ5 A0A1B0GWF2 P61764
PDB IDs		6U8Z	6L03
Enriched GO Terms of Interacting Partners?		Focal Adhesion Nucleotide Binding Regulation Of Endocytosis Regulation Of Vesicle-mediated Transport GTPase Activity GTP Binding Regulation Of Cell Junction Assembly Regulation Of Actin Filament-based Process Protein Kinase Binding Cell Junction Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Transport Actin Cytoskeleton Organization Cytosol Positive Regulation Of Cellular Component Biogenesis Establishment Or Maintenance Of Cell Polarity Regulation Of Cytoskeleton Organization Enzyme Binding Positive Regulation Of Cell Migration Actin Filament-based Process Regulation Of Organelle Organization Plasma Membrane Positive Regulation Of Cell Motility Intracellular Signal Transduction Positive Regulation Of Locomotion Regulation Of Synapse Organization Regulation Of Cellular Component Organization Cell Motility Regulation Of Locomotion Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Postsynapse Regulation Of Cell Projection Assembly G Protein Activity Regulation Of Apoptotic Process Vesicle-mediated Transport Regulation Of Supramolecular Fiber Organization Regulation Of Synaptic Vesicle Recycling Regulation Of Developmental Process Cytoplasm Regulation Of Cell-substrate Junction Organization Regulation Of Programmed Cell Death Glutamatergic Synapse Cell Junction Assembly Regulation Of Actin Filament Organization Protein-containing Complex Cellular Localization Actin Filament Regulation Of Protein-containing Complex Assembly	Regulation Of Vesicle-mediated Transport Modulation Of Chemical Synaptic Transmission Regulation Of Exocytosis Vesicle-mediated Transport Positive Regulation Of Exocytosis SNARE Complex Vesicle Docking Intracellular Protein Transport Exocytosis Synaptic Vesicle Exocytosis Positive Regulation Of Secretion By Cell Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Transport Positive Regulation Of Secretion SNAP Receptor Activity Organelle Localization By Membrane Tethering Positive Regulation Of Synaptic Transmission Regulation Of Protein Localization Establishment Of Localization In Cell Organelle Localization Membrane Docking Regulation Of Transport Vesicle-mediated Transport In Synapse Positive Regulation Of Calcium Ion-dependent Exocytosis Membrane Organization Vesicle Fusion Organelle Membrane Fusion Neurofibrillary Tangle Secretion By Cell Regulation Of Establishment Of Protein Localization Establishment Of Protein Localization Spontaneous Neurotransmitter Secretion Regulation Of Secretion By Cell Regulation Of Synaptic Plasticity Chemical Synaptic Transmission Positive Regulation Of Protein Localization Regulation Of Regulated Secretory Pathway Vesicle Organization SNARE Binding Positive Regulation Of Establishment Of Protein Localization Organelle Fusion Presynaptic Active Zone Membrane Trans-synaptic Signaling Intracellular Transport Neuron Projection Regulation Of Secretion Presynapse Synaptic Signaling Regulation Of Signaling Regulation Of Cell Communication
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