PLD1 and ARIH1

Number of citations: 0 (PubMedID 10926929)
Data Source: HPRD (two hybrid)

		PLD1	ARIH1
Name		phospholipase D1	ariadne RBR E3 ubiquitin protein ligase 1
Structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Endomembrane System Membrane Apical Plasma Membrane Endocytic Vesicle Cytoplasmic Vesicle Late Endosome Membrane Organelle Subcompartment Specific Granule Membrane Perinuclear Region Of Cytoplasm Tertiary Granule Membrane Cholinergic Synapse	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Nuclear Body SCF Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Lewy Body
	Molecular Function	Catalytic Activity Phospholipase D Activity Protein Binding Hydrolase Activity Phosphatidylinositol Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Chemotaxis Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Phospholipid Catabolic Process Lipid Catabolic Process Cellular Response To Nutrient Regulation Of Microvillus Assembly Intracellular Signal Transduction Positive Regulation Of Translation Regulation Of Vesicle-mediated Transport Regulation Of Synaptic Vesicle Cycle	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination PKR/eIFalpha Signaling
Pathways		Synthesis of PG Synthesis of PA Role of phospholipids in phagocytosis Neutrophil degranulation RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle	ISG15 antiviral mechanism RSV-host interactions PKR-mediated signaling Modulation of host responses by IFN-stimulated genes
Drugs		Choline LAX-101 Choline salicylate	None
GWAS		Cerebrospinal fluid AB1-42 levels ( 29274321 ) Eosinophil count ( 32888494 ) Red cell distribution width ( 27863252 28957414 32888494 ) Reticulocyte fraction of red cells ( 32888494 )	No GWAS studies recorded
Interacting Genes		28 interacting genes: ACTA1 ACTB ACTG1 ARF1 ARF6 ARIH1 ARL11 ARL14 BIN1 CAV1 CDC42 EGFR EGLN1 HIF1A PEA15 PIP5K1A PKN1 PKN3 PRKCA RAC1 RALA RHEB RHOA RHOG SNCA SRC STXBP1 VHL	20 interacting genes: BIRC6 CCNE1 CDKN1B CRY1 DCUN1D1 EIF4E2 HSPB1 PCBP1 PLD1 RBX1 SEC31A SLC25A21-AS1 UBC UBE2D1 UBE2D3 UBE2E2 UBE2L3 UBE2L6 UBE2N VAV2
Entrez ID		5337	25820
HPRD ID		03855	05730
Ensembl ID		ENSG00000075651	ENSG00000166233
Uniprot IDs		Q13393 Q59EA4	Q9Y4X5
PDB IDs		6U8Z	1WD2 2M9Y 4KBL 4KC9 5TTE 5UDH 7B5L 7B5M 7B5N 7B5S
GO Terms Enriched among Interactors		Focal Adhesion Nucleotide Binding Regulation Of Endocytosis Regulation Of Vesicle-mediated Transport GTPase Activity GTP Binding Regulation Of Cell Junction Assembly Regulation Of Actin Filament-based Process Protein Kinase Binding Cell Junction Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Transport Actin Cytoskeleton Organization Cytosol Positive Regulation Of Cellular Component Biogenesis Establishment Or Maintenance Of Cell Polarity Regulation Of Cytoskeleton Organization Enzyme Binding Positive Regulation Of Cell Migration Actin Filament-based Process Regulation Of Organelle Organization Plasma Membrane Positive Regulation Of Cell Motility Intracellular Signal Transduction Positive Regulation Of Locomotion Regulation Of Synapse Organization Regulation Of Cellular Component Organization Cell Motility Regulation Of Locomotion Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Postsynapse Regulation Of Cell Projection Assembly G Protein Activity Regulation Of Apoptotic Process Vesicle-mediated Transport Regulation Of Supramolecular Fiber Organization Regulation Of Synaptic Vesicle Recycling Regulation Of Developmental Process Cytoplasm Regulation Of Cell-substrate Junction Organization Regulation Of Programmed Cell Death Glutamatergic Synapse Cell Junction Assembly Regulation Of Actin Filament Organization Protein-containing Complex Cellular Localization Actin Filament Regulation Of Protein-containing Complex Assembly	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Positive Regulation Of Post-translational Protein Modification Post-translational Protein Modification Protein Ubiquitination Protein Polyubiquitination Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Regulation Of Protein Modification Process Protein Modification Process Protein Monoubiquitination Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Modification Process Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process ISG15 Transferase Activity Cytosol Protein K11-linked Ubiquitination Protein Metabolic Process ISG15-protein Conjugation Ubiquitin-dependent Protein Catabolic Process Cell Cycle Phase Transition Ubiquitin-protein Transferase Activator Activity TORC1 Signaling Negative Regulation Of TORC1 Signaling Cytoplasm Negative Regulation Of Signal Transduction G1/S Transition Of Mitotic Cell Cycle Cul4A-RING E3 Ubiquitin Ligase Complex Macromolecule Catabolic Process Cell Cycle G1/S Phase Transition TOR Signaling Negative Regulation Of TOR Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cellular Response To Nutrient Levels Regulation Of TORC1 Signaling Positive Regulation Of Protein Polyubiquitination DNA Damage Response Ubiquitin Binding Ubiquitin-like Protein Transferase Activity Proteolysis Ubiquitin Ligase Complex Protein Neddylation Cullin Family Protein Binding