PLD1 and PKN3

Number of citations of the paper that reports this interaction (PMID 11259428)
6

Data Source:
HPRD (in vivo, in vitro)

		PLD1	PKN3
Gene Name		phospholipase D1, phosphatidylcholine-specific	protein kinase N3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Apical Plasma Membrane Endocytic Vesicle Late Endosome Membrane Perinuclear Region Of Cytoplasm	Nucleus Golgi Apparatus Perinuclear Region Of Cytoplasm
	Molecular Function	Phospholipase D Activity Protein Binding Phosphatidylinositol Binding N-acylphosphatidylethanolamine-specific Phospholipase D Activity	Protein Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Phosphatidylglycerol Biosynthetic Process Chemotaxis Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Lipid Catabolic Process Regulation Of Microvillus Assembly Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process Defense Response To Gram-positive Bacterium	Protein Phosphorylation Signal Transduction Epithelial Cell Migration
Pathways		Synthesis of PA Metabolism of lipids and lipoproteins Synthesis of PG Role of phospholipids in phagocytosis Phospholipid metabolism Glycerophospholipid biosynthesis Fcgamma receptor (FCGR) dependent phagocytosis Innate Immune System
Drugs
Diseases
GWAS			Eating disorders (purging via substances) ( 23568457) Obesity-related traits ( 23251661)
Protein-Protein Interactions		26 interactors: ACTA1 ACTB ACTG1 ARF1 ARF6 ARIH1 BIN1 CAV1 CDC42 EGFR EGLN1 HIF1A PEA15 PIP5K1A PKN1 PKN3 PRKCA RAC1 RALA RHEB RHOA RHOG SNCA SRC STXBP1 VHL	3 interactors: ARHGAP10 ARHGAP26 PLD1
Entrez ID		5337	29941
HPRD ID		03855	17856
Ensembl ID		ENSG00000075651	ENSG00000160447
Uniprot IDs		Q13393 Q59EA4	Q6P5Z2
PDB IDs
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Locomotion Cellular Response To Stimulus Regulation Of Body Fluid Levels Blood Coagulation Wound Healing Hemostasis Chemotaxis Cell Migration Platelet Activation Membrane Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Junction Organization Cell Motility Response To Stimulus Response To Wounding Regulation Of Vesicle-mediated Transport Regulation Of Cellular Localization Actin Cytoskeleton Organization Actin Filament-based Process Vesicle-mediated Transport Cell Projection Organization Regulation Of Signaling Endocytosis Response To External Stimulus Enzyme Linked Receptor Protein Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Endocytosis Organelle Organization Cell Activation Signaling Cell Communication Cell Morphogenesis Involved In Differentiation Axonogenesis Regulation Of Cell Projection Assembly Anatomical Structure Morphogenesis Response To Stress Axon Development Cell Morphogenesis Axon Guidance Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Apoptotic Process Neuron Projection Morphogenesis Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Regulation Of Signal Transduction Regulation Of Cell Death	Small GTPase Mediated Signal Transduction Maintenance Of Golgi Location Positive Regulation Of Rho GTPase Activity Regulation Of Rho GTPase Activity Intracellular Signal Transduction Regulation Of Rho Protein Signal Transduction Regulation Of Microvillus Assembly Establishment Of Golgi Localization Positive Regulation Of Ras GTPase Activity Endomembrane System Organization Phosphatidylglycerol Biosynthetic Process Regulation Of Ras GTPase Activity Golgi Localization Regulation Of Ras Protein Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Phosphatidic Acid Biosynthetic Process Phosphatidic Acid Metabolic Process Positive Regulation Of Hydrolase Activity Cytoskeleton Organization Organelle Transport Along Microtubule Defense Response To Gram-positive Bacterium Golgi Organization Signal Transduction Positive Regulation Of Catalytic Activity Signaling
Tagcloud ?		1alpha abolished believed blocks butanol catalyzes ectopic elevate explored generating glioma hif hydrolysis messenger overexpressed pa pc phosphatidic phosphatidylcholine phospholipase pld2 responsive se secretion tumorigenesis u87 utilize vegf
Tagcloud (Difference) ?		1alpha abolished believed blocks butanol catalyzes ectopic elevate explored generating glioma hif hydrolysis messenger overexpressed pa pc phosphatidic phosphatidylcholine phospholipase pld2 responsive se secretion tumorigenesis u87 utilize vegf
Tagcloud (Intersection) ?