PLD1 and PKN3

Number of citations: 0 (PubMedID 11259428)
Data Source: HPRD (in vivo, in vitro)

		PLD1	PKN3
Name		phospholipase D1	protein kinase N3
Structure			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Endomembrane System Membrane Apical Plasma Membrane Endocytic Vesicle Cytoplasmic Vesicle Late Endosome Membrane Organelle Subcompartment Specific Granule Membrane Perinuclear Region Of Cytoplasm Tertiary Granule Membrane Cholinergic Synapse	Nucleus Cytoplasm Golgi Apparatus Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Catalytic Activity Phospholipase D Activity Protein Binding Hydrolase Activity Phosphatidylinositol Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Protein Serine Kinase Activity
	Biological Process	Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Chemotaxis Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Phospholipid Catabolic Process Lipid Catabolic Process Cellular Response To Nutrient Regulation Of Microvillus Assembly Intracellular Signal Transduction Positive Regulation Of Translation Regulation Of Vesicle-mediated Transport Regulation Of Synaptic Vesicle Cycle	Protein Phosphorylation Signal Transduction Epithelial Cell Migration Intracellular Signal Transduction
Pathways		Synthesis of PG Synthesis of PA Role of phospholipids in phagocytosis Neutrophil degranulation RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle	RHO GTPases activate PKNs RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs		Choline LAX-101 Choline salicylate	None
GWAS		Cerebrospinal fluid AB1-42 levels ( 29274321 ) Eosinophil count ( 32888494 ) Red cell distribution width ( 27863252 28957414 32888494 ) Reticulocyte fraction of red cells ( 32888494 )	Apolipoprotein B levels ( 32203549 ) Asthma ( 31361310 ) Axial length ( 24144296 ) Body mass index ( 26426971 ) Eating disorders (purging via substances) ( 23568457 ) Gamma glutamyl transferase levels ( 29403010 33339817 ) LDL cholesterol levels ( 32203549 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Low density lipoprotein cholesterol levels ( 32154731 ) Neutrophil count ( 32888494 ) Obesity-related traits ( 23251661 ) Platelet count ( 32888494 ) Plateletcrit ( 27863252 32888494 ) White blood cell count ( 32888494 )
Interacting Genes		28 interacting genes: ACTA1 ACTB ACTG1 ARF1 ARF6 ARIH1 ARL11 ARL14 BIN1 CAV1 CDC42 EGFR EGLN1 HIF1A PEA15 PIP5K1A PKN1 PKN3 PRKCA RAC1 RALA RHEB RHOA RHOG SNCA SRC STXBP1 VHL	9 interacting genes: ARHGAP10 ARHGAP26 GOLGA2 KRT31 MTUS2 PLD1 PNMA1 TFIP11 VPS52
Entrez ID		5337	29941
HPRD ID		03855	17856
Ensembl ID		ENSG00000075651	ENSG00000160447
Uniprot IDs		Q13393 Q59EA4	Q6P5Z2
PDB IDs		6U8Z	Not available
GO Terms Enriched among Interactors		Focal Adhesion Nucleotide Binding Regulation Of Endocytosis Regulation Of Vesicle-mediated Transport GTPase Activity GTP Binding Regulation Of Cell Junction Assembly Regulation Of Actin Filament-based Process Protein Kinase Binding Cell Junction Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Transport Actin Cytoskeleton Organization Cytosol Positive Regulation Of Cellular Component Biogenesis Establishment Or Maintenance Of Cell Polarity Regulation Of Cytoskeleton Organization Enzyme Binding Positive Regulation Of Cell Migration Actin Filament-based Process Regulation Of Organelle Organization Plasma Membrane Positive Regulation Of Cell Motility Intracellular Signal Transduction Positive Regulation Of Locomotion Regulation Of Synapse Organization Regulation Of Cellular Component Organization Cell Motility Regulation Of Locomotion Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Postsynapse Regulation Of Cell Projection Assembly G Protein Activity Regulation Of Apoptotic Process Vesicle-mediated Transport Regulation Of Supramolecular Fiber Organization Regulation Of Synaptic Vesicle Recycling Regulation Of Developmental Process Cytoplasm Regulation Of Cell-substrate Junction Organization Regulation Of Programmed Cell Death Glutamatergic Synapse Cell Junction Assembly Regulation Of Actin Filament Organization Protein-containing Complex Cellular Localization Actin Filament Regulation Of Protein-containing Complex Assembly	Syntaxin Binding Endosome Embryonic Ectodermal Digestive Tract Development Endosome Membrane