PLD1 and RALA

Number of citations of the paper that reports this interaction (PMID 9207251)
24

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		PLD1	RALA
Gene Name		phospholipase D1, phosphatidylcholine-specific	v-ral simian leukemia viral oncogene homolog A (ras related)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Apical Plasma Membrane Endocytic Vesicle Late Endosome Membrane Perinuclear Region Of Cytoplasm	Plasma Membrane Focal Adhesion Cell Surface Endocytic Vesicle Midbody Cytoplasmic Vesicle Membrane Cleavage Furrow Extracellular Vesicular Exosome
	Molecular Function	Phospholipase D Activity Protein Binding Phosphatidylinositol Binding N-acylphosphatidylethanolamine-specific Phospholipase D Activity	GTPase Activity Protein Binding GTP Binding Myosin Binding GDP Binding Ubiquitin Protein Ligase Binding Edg-2 Lysophosphatidic Acid Receptor Binding ATPase Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Phosphatidylglycerol Biosynthetic Process Chemotaxis Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Lipid Catabolic Process Regulation Of Microvillus Assembly Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process Defense Response To Gram-positive Bacterium	Cytokinesis Exocytosis Chemotaxis Signal Transduction Ras Protein Signal Transduction Viral Process Regulation Of Exocytosis Actin Cytoskeleton Reorganization Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Filopodium Assembly Membrane Raft Localization Membrane Organization
Pathways		Synthesis of PA Metabolism of lipids and lipoproteins Synthesis of PG Role of phospholipids in phagocytosis Phospholipid metabolism Glycerophospholipid biosynthesis Fcgamma receptor (FCGR) dependent phagocytosis Innate Immune System	Signalling to ERKs Signalling by NGF Signalling to RAS p38MAPK events Translocation of GLUT4 to the plasma membrane NGF signalling via TRKA from the plasma membrane
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: ACTA1 ACTB ACTG1 ARF1 ARF6 ARIH1 BIN1 CAV1 CDC42 EGFR EGLN1 HIF1A PEA15 PIP5K1A PKN1 PKN3 PRKCA RAC1 RALA RHEB RHOA RHOG SNCA SRC STXBP1 VHL	32 interactors: ARF1 CALM1 CNKSR2 EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6B EXOC7 EXOC8 FLNA HRAS LRPAP1 LSM2 PIH1D2 PLCD1 PLD1 PPP2R1B RAB34 RAB8B RALBP1 RALGPS1 RAP1A RAP2A RAP2B RASSF5 REPS1 RGL2 RGL4 SMAD4 YBX3
Entrez ID		5337	5898
HPRD ID		03855	01549
Ensembl ID		ENSG00000075651	ENSG00000006451
Uniprot IDs		Q13393 Q59EA4	P11233
PDB IDs			1UAD 1ZC3 1ZC4 2A78 2A9K 2BOV
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Locomotion Cellular Response To Stimulus Regulation Of Body Fluid Levels Blood Coagulation Wound Healing Hemostasis Chemotaxis Cell Migration Platelet Activation Membrane Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Junction Organization Cell Motility Response To Stimulus Response To Wounding Regulation Of Vesicle-mediated Transport Regulation Of Cellular Localization Actin Cytoskeleton Organization Actin Filament-based Process Vesicle-mediated Transport Cell Projection Organization Regulation Of Signaling Endocytosis Response To External Stimulus Enzyme Linked Receptor Protein Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Endocytosis Organelle Organization Cell Activation Signaling Cell Communication Cell Morphogenesis Involved In Differentiation Axonogenesis Regulation Of Cell Projection Assembly Anatomical Structure Morphogenesis Response To Stress Axon Development Cell Morphogenesis Axon Guidance Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Apoptotic Process Neuron Projection Morphogenesis Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Regulation Of Signal Transduction Regulation Of Cell Death See more	Exocytosis Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Membrane Organization Secretion By Cell Intracellular Signal Transduction Secretion Ras Protein Signal Transduction Establishment Of Protein Localization Protein Localization Vesicle Docking Protein Transport Membrane Docking Rap Protein Signal Transduction Establishment Of Localization In Cell Cellular Localization Vesicle Docking Involved In Exocytosis Positive Regulation Of Protein Autophosphorylation Regulation Of Signaling Post-Golgi Vesicle-mediated Transport Transport Regulation Of Protein Autophosphorylation Organelle Organization Regulation Of Signal Transduction Golgi Vesicle Transport Exocyst Localization Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Platelet Activation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Signaling Cellular Protein Complex Localization Blood Coagulation Cell Communication Positive Regulation Of Ras GTPase Activity Hemostasis Positive Regulation Of Hydrolase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of GTPase Activity Protein Complex Localization Cellular Response To Stimulus Regulation Of Cell Projection Organization Regulation Of GTPase Activity Regulation Of Ras GTPase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Body Fluid Levels Wound Healing Golgi To Plasma Membrane Transport See more
Tagcloud ?		1alpha abolished believed blocks butanol catalyzes ectopic elevate explored generating glioma hif hydrolysis messenger overexpressed pa pc phosphatidic phosphatidylcholine phospholipase pld2 responsive se secretion tumorigenesis u87 utilize vegf	adoptive antitumor capability chimeric combining effectors engineered fused genetically gtp immunotherapeutic killer meaningful mhc moieties ncr1 ncrs nk nkp46 partly proto ralb recognition recognize regressions remarkable retrovirally termed
Tagcloud (Difference) ?		1alpha abolished believed blocks butanol catalyzes ectopic elevate explored generating glioma hif hydrolysis messenger overexpressed pa pc phosphatidic phosphatidylcholine phospholipase pld2 responsive se secretion tumorigenesis u87 utilize vegf	adoptive antitumor capability chimeric combining effectors engineered fused genetically gtp immunotherapeutic killer meaningful mhc moieties ncr1 ncrs nk nkp46 partly proto ralb recognition recognize regressions remarkable retrovirally termed
Tagcloud (Intersection) ?