PLD1 and ARL14

Number of citations of the paper that reports this interaction (PubMedID 35844135)
78

Data Source:
BioGRID (enzymatic study)

		PLD1	ARL14
Description		phospholipase D1	ARF like GTPase 14
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Endomembrane System Membrane Apical Plasma Membrane Endocytic Vesicle Cytoplasmic Vesicle Late Endosome Membrane Organelle Subcompartment Specific Granule Membrane Perinuclear Region Of Cytoplasm Tertiary Granule Membrane Cholinergic Synapse	Cytoplasm Plasma Membrane Cytoplasmic Vesicle
	Molecular Function	Catalytic Activity Phospholipase D Activity Protein Binding Hydrolase Activity Phosphatidylinositol Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding
	Biological Process	Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Chemotaxis Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Phospholipid Catabolic Process Lipid Catabolic Process Cellular Response To Nutrient Regulation Of Microvillus Assembly Intracellular Signal Transduction Positive Regulation Of Translation Regulation Of Vesicle-mediated Transport Regulation Of Synaptic Vesicle Cycle	Intracellular Protein Transport Vesicle-mediated Transport Establishment Of Cell Polarity
Pathways		Synthesis of PG Synthesis of PA Role of phospholipids in phagocytosis Neutrophil degranulation RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle
Drugs		Choline LAX-101 Choline salicylate
Diseases
GWAS		Cerebrospinal fluid AB1-42 levels ( 29274321) Eosinophil count ( 32888494) Red cell distribution width ( 27863252 28957414 32888494) Reticulocyte fraction of red cells ( 32888494)	Alcohol use disorder (total score) ( 30336701) Attention deficit hyperactivity disorder ( 32279069) Diastolic blood pressure ( 27841878) Malaria ( 31844061) Pulse pressure ( 27841878) Response to methotrexate in rheumatoid arthritis ( 24583629) Systolic blood pressure ( 27841878)
Interacting Genes		28 interacting genes: ACTA1 ACTB ACTG1 ARF1 ARF6 ARIH1 ARL11 ARL14 BIN1 CAV1 CDC42 EGFR EGLN1 HIF1A PEA15 PIP5K1A PKN1 PKN3 PRKCA RAC1 RALA RHEB RHOA RHOG SNCA SRC STXBP1 VHL	5 interacting genes: ARNT EXOC3L1 PLD1 SMURF1 UBE2G2
Entrez ID		5337	80117
HPRD ID		03855	07998
Ensembl ID		ENSG00000075651	ENSG00000179674
Uniprot IDs		Q13393 Q59EA4	Q8N4G2
PDB IDs		6U8Z
Enriched GO Terms of Interacting Partners?		Focal Adhesion Nucleotide Binding Regulation Of Endocytosis Regulation Of Vesicle-mediated Transport GTPase Activity GTP Binding Regulation Of Cell Junction Assembly Regulation Of Actin Filament-based Process Protein Kinase Binding Cell Junction Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Transport Actin Cytoskeleton Organization Cytosol Positive Regulation Of Cellular Component Biogenesis Establishment Or Maintenance Of Cell Polarity Regulation Of Cytoskeleton Organization Enzyme Binding Positive Regulation Of Cell Migration Actin Filament-based Process Regulation Of Organelle Organization Plasma Membrane Positive Regulation Of Cell Motility Intracellular Signal Transduction Positive Regulation Of Locomotion Regulation Of Synapse Organization Regulation Of Cellular Component Organization Cell Motility Regulation Of Locomotion Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Postsynapse Regulation Of Cell Projection Assembly G Protein Activity Regulation Of Apoptotic Process Vesicle-mediated Transport Regulation Of Supramolecular Fiber Organization Regulation Of Synaptic Vesicle Recycling Regulation Of Developmental Process Cytoplasm Regulation Of Cell-substrate Junction Organization Regulation Of Programmed Cell Death Glutamatergic Synapse Cell Junction Assembly Regulation Of Actin Filament Organization Protein-containing Complex Cellular Localization Actin Filament Regulation Of Protein-containing Complex Assembly
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