PKP2 and YWHAG

Number of citations of the paper that reports this interaction (PubMedID 15324660)
0

Data Source:
HPRD (in vivo)

		PKP2	YWHAG
Description		plakophilin 2	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
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GO Annotations	Cellular Component	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Intercalated Disc Membrane Cell Junction Desmosome Cell Tip Anchoring Junction	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Focal Adhesion Membrane Vesicle Synapse Extracellular Exosome Presynapse
	Molecular Function	DNA Binding Protein Kinase C Binding Protein Binding Sodium Channel Regulator Activity Intermediate Filament Binding Transmembrane Transporter Binding Alpha-catenin Binding Cadherin Binding Molecular Adaptor Activity Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication	RNA Binding Protein Kinase C Binding Insulin-like Growth Factor Receptor Binding Protein Binding Protein Kinase C Inhibitor Activity Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Identical Protein Binding Phosphorylation-dependent Protein Binding Protein Sequestering Activity
	Biological Process	Desmosome Assembly Desmosome Organization Cell Adhesion Cell-cell Signaling Heart Development Positive Regulation Of Sodium Ion Transport Regulation Of Cell-substrate Adhesion Intermediate Filament Bundle Assembly Maintenance Of Animal Organ Identity Ventricular Cardiac Muscle Tissue Morphogenesis Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Maintenance Of Protein Localization At Cell Tip Regulation Of Substrate Adhesion-dependent Cell Spreading	Cytoplasmic Translation Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of Protein Kinase Activity Protein Targeting Signal Transduction Intracellular Protein Localization Regulation Of Signal Transduction Positive Regulation Of Cell-cell Adhesion SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Cellular Response To Insulin Stimulus Regulation Of Protein Localization Cellular Response To Amino Acid Starvation TORC1 Signaling Cellular Response To Glucose Starvation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Neuron Differentiation Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Regulation Of Synaptic Plasticity Protein Stabilization Negative Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Protein Localization To Lysosome Protein K6-linked Ubiquitination Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Keratinization Formation of the cornified envelope	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex AURKA Activation by TPX2 Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity SPOP-mediated proteasomal degradation of PD-L1(CD274)
Drugs
Diseases		Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Atrial fibrillation ( 29892015 30061737) Blood protein levels ( 30072576) Body mass index (change over time) in lung cancer ( 28044437) Methadone dose in opioid dependence ( 28115739) Obesity-related traits ( 23251661) Parkinson's disease ( 27182965 32201043) Periodontal disease related phenotype (PCT5) ( 26962152) Prevalent atrial fibrillation ( 28416818)	Multiple sclerosis ( 21654844) Schizophrenia ( 30285260)
Interacting Genes		48 interacting genes: ACTN3 AKAP9 ARMC8 BAG4 CARD9 CASK CCDC120 CCDC125 CCHCR1 CTBP1 CTNNB1 DMRTB1 DSC1 DSC2 DSG1 DSG2 DSP EIF4ENIF1 EXOSC8 FHL3 GOLGA2 GRIPAP1 GTF2IRD1 HOOK2 HSPB2 JUP KLC4 KRT18 KRT31 KRT5 MAGOHB MARK3 MTUS2 NCKIPSD NDEL1 PIBF1 PLEKHG4 POLR3A RABEP1 RBM5 RBPMS ROPN1 SMAD9 SPTA1 TEKT4 VHL VIM YWHAG	286 interacting genes: ABL1 ABLIM1 ACIN1 AFDN AKAP13 AKT1S1 ALB ANKHD1-EIF4EBP3 ANKS1A APP ARAF ARHGEF2 ARHGEF6 ARHGEF7 ATP5F1A ATP5F1B ATP6V0B BAD BAIAP2 BAIAP2L1 BCLAF1 BCR BRAF C1QBP CAD CAMKK1 CASP3 CBL CCNY CCS CCT2 CDC5L CDK11B CDK16 CDK17 CDKN1B CEP170 CEP250 CEP95 CFAP20 CFL1 CGN CGNL1 CHAF1A CHEK1 CKAP2 CLASP1 CLINT1 CLK1 CLK2 CLK3 CLTC COPS5 CPAP CPSF3 CRTC1 CRTC2 CRTC3 CSE1L CTNND1 CTPS1 CYFIP2 DCAF7 DCP1A DDX17 DDX27 DDX39B DENND4A DFFA DHX15 DISC1 DOCK7 DYNC1H1 DYRK1A EDC3 EEF1A1 EEF1G EML3 EPB41L3 EPN2 ERC1 EWSR1 EXO1 FAM13B FARP2 FGD6 FLNA FOXO1 FOXO3 GBF1 GIT1 GIT2 GSK3A GTPBP4 H3C1 HDAC4 HDAC7 HECTD1 HGF HNRNPAB HNRNPH1 HNRNPM HOXC10 HSPA1A HSPA8 HSPA9 HSPB6 HSPD1 IGF1R IL7R ING1 INPP5E IRS1 IRS2 IRS4 JAKMIP1 KANK1 KAT5 KCNK15 KCNK3 KCNK9 KIAA0408 KIAA0930 KIF1B KIF1C KIF23 KIF5B KIF5C KLC2 KLC3 KRT18 LARP1 LATS2 LBR LIMA1 LMO7 LRCH3 LSR LTB4R LUC7L2 LUC7L3 MAGOHB MAP3K2 MAP3K20 MAP3K3 MAPKAP1 MARK3 MCM5 MDM4 MFAP1 MICALL1 MIEF1 MPHOSPH9 MPRIP MSL2 MYCBP2 MYH10 N4BP3 NCAM2 NCKAP1 NCKIPSD NDE1 NDEL1 NEDD4L NEFL NHSL2 NOLC1 NUFIP2 NUMBL OSBPL3 P4HB PABPC1 PAK1 PAK4 PARD3 PARD3B PFKFB2 PGAM5 PHLDB2 PI4KB PIK3C3 PIK3R1 PKP2 PLA2G12A PLEKHA5 PNN POT1 PPFIA1 PPFIBP1 PPIG PPP1R12A PPP6R3 PRKCA PRKCB PRKCD PRKCG PRKCQ PRKDC PRLR PRMT1 PRMT5 PRP4K PRPF38B PRPF40A PTPN14 PUF60 RAB11FIP2 RAB11FIP5 RABEP1 RACGAP1 RAF1 RAI14 RALGPS2 RAPGEF6 RASAL2 RASSF8 RGS12 RIPK2 RIPOR2 RMDN3 RNPS1 RPS2 RRM1 SAMD4A SAMD4B SF3B3 SFN SH3BP4 SH3BP5L SHKBP1 SHPRH SHROOM2 SIMC1 SLC25A3 SMARCD1 SNRNP200 SON SPOP SPTBN1 SRC SRGAP2 SRPK1 SRRM1 SRRM2 SRSF10 SRSF3 STK11 SVIL SYNPO SYNPO2 TAB1 TAF15 TBC1D1 TBC1D4 TERF1 TFE3 THRAP3 TIAM1 TINF2 TJP2 TMEM102 TNFAIP3 TP53 TP53BP2 TRA2A TRA2B TSC1 TSC2 TUBA4A TUBB TUBB4A UBC UBE3A UCP2 UCP3 USP37 USP8 WEE1 WNK1 YAP1 YWHAB YWHAE YWHAH YWHAQ ZBTB21 ZFP36
Entrez ID		5318	7532
HPRD ID		04177	05639
Ensembl ID		ENSG00000057294	ENSG00000170027
Uniprot IDs		A0A8V8TPU9 A0AAQ5BGY2 Q99959	P61981
PDB IDs		3TT9	2B05 3UZD 4E2E 4J6S 4O46 5D3E 6A5S 6BYJ 6BYL 6BZD 6FEL 6GKF 6GKG 6S9K 6SAD 6Y4K 6Y6B 6ZBT 6ZC9 7A6R 7A6Y
Enriched GO Terms of Interacting Partners?		Desmosome Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Cytoskeleton Organization Cornified Envelope Regulation Of Cardiac Muscle Cell Action Potential Cytoplasm Regulation Of Ventricular Cardiac Muscle Cell Action Potential Desmosome Organization Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Cytoskeleton Regulation Of Action Potential Cytosol Regulation Of Cardiac Muscle Cell Contraction Cell Junction Scaffold Protein Binding Heterotypic Cell-cell Adhesion Microtubule Organizing Center Regulation Of Striated Muscle Contraction Structural Constituent Of Cytoskeleton Regulation Of Heart Rate Cell-cell Junction Organization Organelle Organization Catenin-TCF7L2 Complex Cell-cell Junction Homotypic Cell-cell Adhesion Intracellular Protein Localization Protein Binding Intermediate Filament Organization Cellular Response To Indole-3-methanol Regulation Of Muscle System Process Nucleus Regulation Of Cardiac Muscle Contraction Microtubule Nucleation Cell-cell Adhesion Microtubule-based Process Response To Indole-3-methanol Regulation Of Muscle Contraction Anchoring Junction Fascia Adherens Adherens Junction Focal Adhesion Protein-DNA Complex Regulation Of Heart Contraction	Cytosol Cytoplasm Protein Binding Regulation Of Supramolecular Fiber Organization RNA Splicing Cadherin Binding Cytoskeleton Regulation Of Protein Localization Regulation Of Cellular Component Organization Regulation Of Organelle Organization Protein Serine Kinase Activity ATP Binding Regulation Of Cytoskeleton Organization Protein Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of RNA Splicing Nucleus RNA Binding MRNA Metabolic Process Nucleotide Binding Cellular Component Assembly Focal Adhesion Intracellular Signal Transduction Kinase Activity Organelle Organization Cytoskeleton Organization MRNA Splicing, Via Spliceosome Microtubule RNA Splicing, Via Transesterification Reactions Nucleoplasm Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing MRNA Processing Regulation Of Cell Cycle Positive Regulation Of Cellular Component Organization Regulation Of Protein Metabolic Process Small GTPase Binding Nuclear Speck Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Protein-containing Complex Regulation Of Programmed Cell Death Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Actin Filament Organization Macromolecule Metabolic Process Protein Phosphorylation Anchoring Junction Negative Regulation Of Supramolecular Fiber Organization Protein Domain Specific Binding Phosphorylation
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