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PKP2 and EXOSC8
Number of citations of the paper that reports this interaction (PubMedID
34133714
)
84
Data Source:
BioGRID
(two hybrid)
PKP2
EXOSC8
Description
plakophilin 2
exosome component 8
Image
GO Annotations
Cellular Component
Cornified Envelope
Nucleus
Nucleoplasm
Cytoplasm
Intermediate Filament
Plasma Membrane
Cell-cell Junction
Adherens Junction
Intercalated Disc
Membrane
Cell Junction
Desmosome
Cell Tip
Anchoring Junction
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Fibrillar Center
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Cytosol
Nucleolar Exosome (RNase Complex)
Exoribonuclease Complex
Molecular Function
DNA Binding
Protein Kinase C Binding
Protein Binding
Sodium Channel Regulator Activity
Intermediate Filament Binding
Transmembrane Transporter Binding
Alpha-catenin Binding
Cadherin Binding
Molecular Adaptor Activity
Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
RNA Binding
RNA Exonuclease Activity
Protein Binding
MRNA 3'-UTR AU-rich Region Binding
Identical Protein Binding
Biological Process
Desmosome Assembly
Desmosome Organization
Cell Adhesion
Cell-cell Signaling
Heart Development
Positive Regulation Of Sodium Ion Transport
Regulation Of Cell-substrate Adhesion
Intermediate Filament Bundle Assembly
Maintenance Of Animal Organ Identity
Ventricular Cardiac Muscle Tissue Morphogenesis
Protein Localization To Plasma Membrane
Cardiac Muscle Cell Action Potential Involved In Contraction
Ventricular Cardiac Muscle Cell Action Potential
Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication
Regulation Of Heart Rate By Cardiac Conduction
Cell-cell Adhesion
Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Maintenance Of Protein Localization At Cell Tip
Regulation Of Substrate Adhesion-dependent Cell Spreading
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
RRNA Processing
RNA Processing
RNA Catabolic Process
RRNA Catabolic Process
U1 SnRNA 3'-end Processing
U4 SnRNA 3'-end Processing
U5 SnRNA 3'-end Processing
Nuclear MRNA Surveillance
Nuclear Polyadenylation-dependent RRNA Catabolic Process
TRAMP-dependent TRNA Surveillance Pathway
Pathways
Keratinization
Formation of the cornified envelope
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Nuclear RNA decay
Drugs
Diseases
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS
Atrial fibrillation (
29892015
30061737
)
Blood protein levels (
30072576
)
Body mass index (change over time) in lung cancer (
28044437
)
Methadone dose in opioid dependence (
28115739
)
Obesity-related traits (
23251661
)
Parkinson's disease (
27182965
32201043
)
Periodontal disease related phenotype (PCT5) (
26962152
)
Prevalent atrial fibrillation (
28416818
)
Interacting Genes
48 interacting genes:
ACTN3
AKAP9
ARMC8
BAG4
CARD9
CASK
CCDC120
CCDC125
CCHCR1
CTBP1
CTNNB1
DMRTB1
DSC1
DSC2
DSG1
DSG2
DSP
EIF4ENIF1
EXOSC8
FHL3
GOLGA2
GRIPAP1
GTF2IRD1
HOOK2
HSPB2
JUP
KLC4
KRT18
KRT31
KRT5
MAGOHB
MARK3
MTUS2
NCKIPSD
NDEL1
PIBF1
PLEKHG4
POLR3A
RABEP1
RBM5
RBPMS
ROPN1
SMAD9
SPTA1
TEKT4
VHL
VIM
YWHAG
112 interacting genes:
AEN
ANKHD1
ATF2
C22orf39
CCDC28A-AS1
CCL14
CCSER2
CNNM3
COL23A1
COX5A
CPSF7
CRMP1
CWC22
DDIT4L
DIS3
DUSP23
ERAL1
EXOSC1
EXOSC10
EXOSC2
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC9
FAM161B
FAM90A1
FHOD1
FOXD4L1
FOXN3
FRG1
FSAF1
FYTTD1
GEM
HAPLN2
HOXB9
ILF2
INCA1
KANK2
KCNJ11
LENG1
LMO4
LNX1
LSM1
LSM4
LSM7
MACIR
METTL14
MKRN1
MORN4
MRPL2
MTREX
MYOZ1
NEDD9
NTAQ1
NXF1
OTUD4
PACSIN2
PALS2
PHF21A
PIAS2
PKP2
POLDIP3
PRC1
PRPF31
PRPF6
PRR3
RASD1
RASSF1
RBBP4
RBM22
RBM7
REL
RFC5
RPL3
RPLP0
RPP14
RPS28
RUSC1
RXRB
SARNP
SF1
SFPQ
SGO2
SLAIN1
SLIRP
SNAI1
SNRPA
SNRPB
SNRPC
SNRPN
SNW1
SOCS7
SPATC1L
SRPK2
SRSF10
SUGP2
TBRG1
TCEA2
TFAP4
TFIP11
TXNDC17
TXNDC9
UBC
UNKL
UPF2
USP2
USP6
UTP14A
XRN1
XRN2
ZFP36
Entrez ID
5318
11340
HPRD ID
04177
09351
Ensembl ID
ENSG00000057294
ENSG00000120699
Uniprot IDs
A0A8V8TPU9
A0AAQ5BGY2
Q99959
Q96B26
PDB IDs
3TT9
2NN6
6D6Q
6D6R
6H25
9G8M
9G8N
9G8O
9G8P
Enriched GO Terms of Interacting Partners
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Desmosome
Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication
Cardiac Muscle Cell-cardiac Muscle Cell Adhesion
Cytoskeleton Organization
Cornified Envelope
Regulation Of Cardiac Muscle Cell Action Potential
Cytoplasm
Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Desmosome Organization
Regulation Of Heart Rate By Cardiac Conduction
Intercalated Disc
Cardiac Conduction
Intermediate Filament-based Process
Intermediate Filament Cytoskeleton Organization
Intermediate Filament
Cytoskeleton
Regulation Of Action Potential
Cytosol
Regulation Of Cardiac Muscle Cell Contraction
Cell Junction
Scaffold Protein Binding
Heterotypic Cell-cell Adhesion
Microtubule Organizing Center
Regulation Of Striated Muscle Contraction
Structural Constituent Of Cytoskeleton
Regulation Of Heart Rate
Cell-cell Junction Organization
Organelle Organization
Catenin-TCF7L2 Complex
Cell-cell Junction
Homotypic Cell-cell Adhesion
Intracellular Protein Localization
Protein Binding
Intermediate Filament Organization
Cellular Response To Indole-3-methanol
Regulation Of Muscle System Process
Nucleus
Regulation Of Cardiac Muscle Contraction
Microtubule Nucleation
Cell-cell Adhesion
Microtubule-based Process
Response To Indole-3-methanol
Regulation Of Muscle Contraction
Anchoring Junction
Fascia Adherens
Adherens Junction
Focal Adhesion
Protein-DNA Complex
Regulation Of Heart Contraction
RNA Binding
MRNA Metabolic Process
Exosome (RNase Complex)
RNA Processing
RNA Metabolic Process
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Nucleic Acid Metabolic Process
Nucleolar Exosome (RNase Complex)
RNA Splicing, Via Transesterification Reactions
Nucleus
Nuclear-transcribed MRNA Catabolic Process
Nuclear MRNA Surveillance
RNA Catabolic Process
MRNA Splicing, Via Spliceosome
MRNA Catabolic Process
RNA Exonuclease Activity
MRNA Processing
RNA Splicing
Nucleoplasm
Nucleobase-containing Compound Metabolic Process
Spliceosomal Complex
Nuclear RNA Surveillance
U4 SnRNA 3'-end Processing
RNA Surveillance
RRNA Catabolic Process
3'-5'-RNA Exonuclease Activity
Nucleobase-containing Compound Catabolic Process
Nucleic Acid Binding
SnRNA Metabolic Process
RRNA Metabolic Process
RRNA Processing
Catalytic Step 2 Spliceosome
Poly(A)-dependent SnoRNA 3'-end Processing
SnRNA 3'-end Processing
Ribonucleoprotein Complex
U4/U6 X U5 Tri-snRNP Complex
Macromolecule Metabolic Process
Nucleolus
Exoribonuclease Complex
Negative Regulation Of Macromolecule Metabolic Process
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
TRNA Surveillance
TRAMP-dependent TRNA Surveillance Pathway
Nuclear Polyadenylation-dependent RRNA Catabolic Process
Sno(s)RNA Metabolic Process
SnRNA Processing
RNA 3'-end Processing
Negative Regulation Of Macromolecule Biosynthetic Process
Protein Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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