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PKP2 and PLEKHG4
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
PKP2
PLEKHG4
Description
plakophilin 2
pleckstrin homology and RhoGEF domain containing G4
Image
No pdb structure
GO Annotations
Cellular Component
Cornified Envelope
Nucleus
Nucleoplasm
Cytoplasm
Intermediate Filament
Plasma Membrane
Cell-cell Junction
Adherens Junction
Intercalated Disc
Membrane
Cell Junction
Desmosome
Cell Tip
Anchoring Junction
Cytoplasm
Cytosol
Plasma Membrane
Extrinsic Component Of Membrane
Molecular Function
DNA Binding
Protein Kinase C Binding
Protein Binding
Sodium Channel Regulator Activity
Intermediate Filament Binding
Transmembrane Transporter Binding
Alpha-catenin Binding
Cadherin Binding
Molecular Adaptor Activity
Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Biological Process
Desmosome Assembly
Desmosome Organization
Cell Adhesion
Cell-cell Signaling
Heart Development
Positive Regulation Of Sodium Ion Transport
Regulation Of Cell-substrate Adhesion
Intermediate Filament Bundle Assembly
Maintenance Of Animal Organ Identity
Ventricular Cardiac Muscle Tissue Morphogenesis
Protein Localization To Plasma Membrane
Cardiac Muscle Cell Action Potential Involved In Contraction
Ventricular Cardiac Muscle Cell Action Potential
Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication
Regulation Of Heart Rate By Cardiac Conduction
Cell-cell Adhesion
Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Maintenance Of Protein Localization At Cell Tip
Regulation Of Substrate Adhesion-dependent Cell Spreading
Axon Guidance
Regulation Of Small GTPase Mediated Signal Transduction
Pathways
Keratinization
Formation of the cornified envelope
RHOA GTPase cycle
CDC42 GTPase cycle
RAC1 GTPase cycle
Drugs
Diseases
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS
Atrial fibrillation (
29892015
30061737
)
Blood protein levels (
30072576
)
Body mass index (change over time) in lung cancer (
28044437
)
Methadone dose in opioid dependence (
28115739
)
Obesity-related traits (
23251661
)
Parkinson's disease (
27182965
32201043
)
Periodontal disease related phenotype (PCT5) (
26962152
)
Prevalent atrial fibrillation (
28416818
)
A body shape index (
34021172
)
Heel bone mineral density (
28869591
)
High density lipoprotein cholesterol levels (
33339817
)
Refractive error (
32231278
)
Waist circumference adjusted for body mass index (
34021172
)
Interacting Genes
48 interacting genes:
ACTN3
AKAP9
ARMC8
BAG4
CARD9
CASK
CCDC120
CCDC125
CCHCR1
CTBP1
CTNNB1
DMRTB1
DSC1
DSC2
DSG1
DSG2
DSP
EIF4ENIF1
EXOSC8
FHL3
GOLGA2
GRIPAP1
GTF2IRD1
HOOK2
HSPB2
JUP
KLC4
KRT18
KRT31
KRT5
MAGOHB
MARK3
MTUS2
NCKIPSD
NDEL1
PIBF1
PLEKHG4
POLR3A
RABEP1
RBM5
RBPMS
ROPN1
SMAD9
SPTA1
TEKT4
VHL
VIM
YWHAG
65 interacting genes:
A1CF
ARHGEF5
ARMC7
BEX2
CCDC120
CCDC187
CDC42
CDKN2C
CHIC2
COIL
DCUN1D5
DPPA3
DTX2
DUSP13B
FAM161A
FGD2
GATA3
GCM2
GSTZ1
HCK
HOXB9
HOXC8
KRT3
KRT75
MALSU1
MATR3
MDFI
METAP1
MSRB3
MTA1
MYEF2
MYOZ1
NATD1
OTX1
PFKFB1
PKP2
PRPF18
PRPF31
PSMB1
RHOA
RIN1
SAXO1
SAXO4
SETD5
SH2D4A
SHISA6
SIX1
SMCP
SMG9
TBC1D22B
TBX18
TEKT3
TENT5D
TFAP2D
TFG
TRIM55
TRIM63
TSSK3
TTC23
USP2
VPS37C
ZCCHC14
ZNF148
ZNF319
ZNF648
Entrez ID
5318
25894
HPRD ID
04177
10890
Ensembl ID
ENSG00000057294
ENSG00000196155
Uniprot IDs
A0A8V8TPU9
A0AAQ5BGY2
Q99959
A0A024R6X4
Q58EX7
PDB IDs
3TT9
Enriched GO Terms of Interacting Partners
?
Desmosome
Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication
Cardiac Muscle Cell-cardiac Muscle Cell Adhesion
Cytoskeleton Organization
Cornified Envelope
Regulation Of Cardiac Muscle Cell Action Potential
Cytoplasm
Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Desmosome Organization
Regulation Of Heart Rate By Cardiac Conduction
Intercalated Disc
Cardiac Conduction
Intermediate Filament-based Process
Intermediate Filament Cytoskeleton Organization
Intermediate Filament
Cytoskeleton
Regulation Of Action Potential
Cytosol
Regulation Of Cardiac Muscle Cell Contraction
Cell Junction
Scaffold Protein Binding
Heterotypic Cell-cell Adhesion
Microtubule Organizing Center
Regulation Of Striated Muscle Contraction
Structural Constituent Of Cytoskeleton
Regulation Of Heart Rate
Cell-cell Junction Organization
Organelle Organization
Catenin-TCF7L2 Complex
Cell-cell Junction
Homotypic Cell-cell Adhesion
Intracellular Protein Localization
Protein Binding
Intermediate Filament Organization
Cellular Response To Indole-3-methanol
Regulation Of Muscle System Process
Nucleus
Regulation Of Cardiac Muscle Contraction
Microtubule Nucleation
Cell-cell Adhesion
Microtubule-based Process
Response To Indole-3-methanol
Regulation Of Muscle Contraction
Anchoring Junction
Fascia Adherens
Adherens Junction
Focal Adhesion
Protein-DNA Complex
Regulation Of Heart Contraction
Protein Binding
Regulation Of Podosome Assembly
Positive Regulation Of Ureteric Bud Formation
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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