YWHAG and PRKCA

Number of citations of the paper that reports this interaction (PubMedID 10433554)
0

Data Source:
HPRD (in vivo)

		YWHAG	PRKCA
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma	protein kinase C alpha
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Focal Adhesion Membrane Vesicle Synapse Extracellular Exosome Presynapse	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Mitochondrial Membrane Protein-containing Complex Alphav-beta3 Integrin-PKCalpha Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	RNA Binding Protein Kinase C Binding Insulin-like Growth Factor Receptor Binding Protein Binding Protein Kinase C Inhibitor Activity Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Identical Protein Binding Phosphorylation-dependent Protein Binding Protein Sequestering Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Signaling Receptor Binding Integrin Binding Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Enzyme Binding Diacylglycerol Binding Histone H3T6 Kinase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Cytoplasmic Translation Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of Protein Kinase Activity Protein Targeting Signal Transduction Intracellular Protein Localization Regulation Of Signal Transduction Positive Regulation Of Cell-cell Adhesion SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Cellular Response To Insulin Stimulus Regulation Of Protein Localization Cellular Response To Amino Acid Starvation TORC1 Signaling Cellular Response To Glucose Starvation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Neuron Differentiation Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Regulation Of Synaptic Plasticity Protein Stabilization Negative Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Protein Localization To Lysosome Protein K6-linked Ubiquitination Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling	Response To Reactive Oxygen Species Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Desmosome Assembly Chromatin Remodeling Protein Phosphorylation Apoptotic Process Mitotic Nuclear Membrane Disassembly Cell Adhesion Learning Or Memory Response To Mechanical Stimulus Response To Toxic Substance Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Translation Central Nervous System Neuron Axonogenesis Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Cell Migration Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Insulin Secretion Response To Estradiol Negative Regulation Of Glial Cell Apoptotic Process Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Peptide Hormone Regulation Of MRNA Stability Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Ethanol Positive Regulation Of Macrophage Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Bone Resorption Positive Regulation Of Cell Adhesion Positive Regulation Of Exocytosis Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Transport Response To Corticosterone Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synapse Assembly Renal Sodium Ion Absorption Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase C Signaling Response To Interleukin-1 Regulation Of Platelet Aggregation Apoptotic Signaling Pathway Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Angiotensin-activated Signaling Pathway Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Response To Phorbol 13-acetate 12-myristate Positive Regulation Of Dense Core Granule Biogenesis
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex AURKA Activation by TPX2 Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity SPOP-mediated proteasomal degradation of PD-L1(CD274)	Calmodulin induced events Disinhibition of SNARE formation SHC1 events in ERBB2 signaling Signaling by SCF-KIT Regulation of KIT signaling EGFR Transactivation by Gastrin Inactivation, recovery and regulation of the phototransduction cascade Syndecan interactions Acetylcholine regulates insulin secretion Ca2+ pathway Trafficking of GluR2-containing AMPA receptors G alpha (z) signalling events Depolymerization of the Nuclear Lamina HuR (ELAVL1) binds and stabilizes mRNA WNT5A-dependent internalization of FZD4 VEGFR2 mediated cell proliferation RHO GTPases Activate NADPH Oxidases Response to elevated platelet cytosolic Ca2+ RET signaling ROBO receptors bind AKAP5 ROBO receptors bind AKAP5
Drugs			Phosphatidyl serine Vitamin E Tamoxifen Staurosporine Dequalinium Ingenol mebutate Aprinocarsen Midostaurin Perifosine Ellagic acid Benzoyl peroxide Bryostatin 1 alpha-Tocopherol succinate D-alpha-Tocopherol acetate
Diseases
GWAS		Multiple sclerosis ( 21654844) Schizophrenia ( 30285260)	Appendicular lean mass ( 33097823) Bipolar disorder ( 31043756) Body composition traits ( 30026463) Brugada syndrome ( 35210625) Cardiorespiratory fitness (800m run time) ( 32572135) Carotid intima media thickness x smoking interaction ( 32117412) Coronary artery calcification ( 23870195) Cryptosporidiosis ( 32019797) Daytime nap ( 33568662) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Feeling guilty ( 29500382) Food addiction ( 27106561) Gout ( 22179738) Haemorrhoidal disease ( 33888516) Height ( 22021425) Heschl's gyrus morphology ( 25130324) Hypertrophic cardiomyopathy ( 33495596 33495597) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Lateral occipital cortex volume ( 31530798) Neuroticism ( 29255261) Percent glycated albumin ( 29844224) Possible neuropathic pain in post total joint replacement surgery for osteoarthritis ( 28051079) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) PR interval ( 32439900) QRS complex (12-leadsum) ( 27659466) QRS complex (Sokolow-Lyon) ( 27659466) QRS duration ( 30012220 27577874 27659466) QT interval ( 24952745 29213071 29874175) Systolic blood pressure ( 31170924) Total glycated albumin levels ( 29844224)
Interacting Genes		286 interacting genes: ABL1 ABLIM1 ACIN1 AFDN AKAP13 AKT1S1 ALB ANKHD1-EIF4EBP3 ANKS1A APP ARAF ARHGEF2 ARHGEF6 ARHGEF7 ATP5F1A ATP5F1B ATP6V0B BAD BAIAP2 BAIAP2L1 BCLAF1 BCR BRAF C1QBP CAD CAMKK1 CASP3 CBL CCNY CCS CCT2 CDC5L CDK11B CDK16 CDK17 CDKN1B CEP170 CEP250 CEP95 CFAP20 CFL1 CGN CGNL1 CHAF1A CHEK1 CKAP2 CLASP1 CLINT1 CLK1 CLK2 CLK3 CLTC COPS5 CPAP CPSF3 CRTC1 CRTC2 CRTC3 CSE1L CTNND1 CTPS1 CYFIP2 DCAF7 DCP1A DDX17 DDX27 DDX39B DENND4A DFFA DHX15 DISC1 DOCK7 DYNC1H1 DYRK1A EDC3 EEF1A1 EEF1G EML3 EPB41L3 EPN2 ERC1 EWSR1 EXO1 FAM13B FARP2 FGD6 FLNA FOXO1 FOXO3 GBF1 GIT1 GIT2 GSK3A GTPBP4 H3C1 HDAC4 HDAC7 HECTD1 HGF HNRNPAB HNRNPH1 HNRNPM HOXC10 HSPA1A HSPA8 HSPA9 HSPB6 HSPD1 IGF1R IL7R ING1 INPP5E IRS1 IRS2 IRS4 JAKMIP1 KANK1 KAT5 KCNK15 KCNK3 KCNK9 KIAA0408 KIAA0930 KIF1B KIF1C KIF23 KIF5B KIF5C KLC2 KLC3 KRT18 LARP1 LATS2 LBR LIMA1 LMO7 LRCH3 LSR LTB4R LUC7L2 LUC7L3 MAGOHB MAP3K2 MAP3K20 MAP3K3 MAPKAP1 MARK3 MCM5 MDM4 MFAP1 MICALL1 MIEF1 MPHOSPH9 MPRIP MSL2 MYCBP2 MYH10 N4BP3 NCAM2 NCKAP1 NCKIPSD NDE1 NDEL1 NEDD4L NEFL NHSL2 NOLC1 NUFIP2 NUMBL OSBPL3 P4HB PABPC1 PAK1 PAK4 PARD3 PARD3B PFKFB2 PGAM5 PHLDB2 PI4KB PIK3C3 PIK3R1 PKP2 PLA2G12A PLEKHA5 PNN POT1 PPFIA1 PPFIBP1 PPIG PPP1R12A PPP6R3 PRKCA PRKCB PRKCD PRKCG PRKCQ PRKDC PRLR PRMT1 PRMT5 PRP4K PRPF38B PRPF40A PTPN14 PUF60 RAB11FIP2 RAB11FIP5 RABEP1 RACGAP1 RAF1 RAI14 RALGPS2 RAPGEF6 RASAL2 RASSF8 RGS12 RIPK2 RIPOR2 RMDN3 RNPS1 RPS2 RRM1 SAMD4A SAMD4B SF3B3 SFN SH3BP4 SH3BP5L SHKBP1 SHPRH SHROOM2 SIMC1 SLC25A3 SMARCD1 SNRNP200 SON SPOP SPTBN1 SRC SRGAP2 SRPK1 SRRM1 SRRM2 SRSF10 SRSF3 STK11 SVIL SYNPO SYNPO2 TAB1 TAF15 TBC1D1 TBC1D4 TERF1 TFE3 THRAP3 TIAM1 TINF2 TJP2 TMEM102 TNFAIP3 TP53 TP53BP2 TRA2A TRA2B TSC1 TSC2 TUBA4A TUBB TUBB4A UBC UBE3A UCP2 UCP3 USP37 USP8 WEE1 WNK1 YAP1 YWHAB YWHAE YWHAH YWHAQ ZBTB21 ZFP36	230 interacting genes: ACTA1 ADAP1 ADCY5 ADD1 ADD3 ADRA1B AFAP1 AKAP12 AKAP5 ANXA2 ANXA7 APLP2 ARHGEF1 ATP1A1 ATP2B1 ATP2B2 AVPR1A BCL2 BTG2 BTK C1QBP CACYBP CASR CAVIN2 CBL CD163 CD5 CD9 CDC42 CDKN2A CFTR CHAT CISH CORO1B CREM CYP3A4 CYTH2 DDX5 DGKD DGKZ DLG4 DLX3 DNM1 DVL2 EDF1 EEF1D EGFR EGLN2 EIF2S1 EIF4E EIF4EBP1 ELAVL1 ENTPD5 EP300 EWSR1 EZR F11R FAS FBXO25 FBXO7 FCGR2B FCGR3A FLNA FLNC FSCN1 GABRB3 GABRG2 GABRR1 GABRR2 GFAP GFPT1 GJA1 GJB1 GLI3 GMFB GNA12 GNA15 GPM6A GRIA1 GRIA2 GRIA4 GRIN1 GRIN2A GRIN2B GRK2 GRM1 GRM5 GSK3A GSK3B H1-1 H1-2 H1-3 H1-4 H1-5 H1-6 H3-4 H3C1 HABP4 HAND1 HAND2 HES1 HLA-A HMGA1 HMGA2 HMGB1 HMGN1 HMGN2 HR HSP90AA1 HSPA1A HSPB8 IKBKB INSR ITGB1 ITGB2 ITGB4 ITPKA ITPKB KCNE1 KCNE4 KCNQ2 KIT KLF5 KRT18 LCK LMNA LMNB1 MAPKAP1 MAPT MARCKS MBP MGMT MTOR MYLK MYOD1 NCF1 NF2 NFATC1 NFE2L2 NFKBIA NHERF1 NHERF2 NOS1 NOXA1 NR1H2 NRGN NUMB OGG1 OPRD1 PA2G4 PAM PDLIM7 PEA15 PEBP1 PFKFB1 PFKFB2 PHB2 PICK1 PLA2G4A PLCB1 PLD1 PLD2 POLB PPARA PPARG PPM1A PPP1R14A PRKCZ PRKG1 PSMB4 PTGIR PTPN1 PTPN11 PTPN12 PTPN6 RAC1 RACK1 RAF1 RALBP1 RARA RBCK1 RGS19 RGS2 RGS7 RHO RHOA RNF31 RPL10 RRAD SACM1L SCRIB SCTR SDC2 SDC4 SELL SEMG1 SEMG2 SHC1 SLC1A1 SLC6A9 SMURF1 SNAP23 SNAP25 SPAG1 SPP1 SRC STMN1 STXBP1 STXBP3 SYK TBXA2R TEP1 TERT THOC5 TIAM1 TNNI3 TNNT2 TNP1 TNP2 TOP2A TP53 TRIM29 TRIM41 TRPC3 TRPV6 VCL VTN XK YWHAG YWHAZ
Entrez ID		7532	5578
HPRD ID		05639	01498
Ensembl ID		ENSG00000170027	ENSG00000154229
Uniprot IDs		P61981	J3KRN5 L7RSM7 P17252 Q7Z727
PDB IDs		2B05 3UZD 4E2E 4J6S 4O46 5D3E 6A5S 6BYJ 6BYL 6BZD 6FEL 6GKF 6GKG 6S9K 6SAD 6Y4K 6Y6B 6ZBT 6ZC9 7A6R 7A6Y	2ELI 3IW4 4DNL 4RA4 8U37 8UAK
Enriched GO Terms of Interacting Partners?		Cytosol Cytoplasm Protein Binding Regulation Of Supramolecular Fiber Organization RNA Splicing Cadherin Binding Cytoskeleton Regulation Of Protein Localization Regulation Of Cellular Component Organization Regulation Of Organelle Organization Protein Serine Kinase Activity ATP Binding Regulation Of Cytoskeleton Organization Protein Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of RNA Splicing Nucleus RNA Binding MRNA Metabolic Process Nucleotide Binding Cellular Component Assembly Focal Adhesion Intracellular Signal Transduction Kinase Activity Organelle Organization Cytoskeleton Organization MRNA Splicing, Via Spliceosome Microtubule RNA Splicing, Via Transesterification Reactions Nucleoplasm Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing MRNA Processing Regulation Of Cell Cycle Positive Regulation Of Cellular Component Organization Regulation Of Protein Metabolic Process Small GTPase Binding Nuclear Speck Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Protein-containing Complex Regulation Of Programmed Cell Death Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Actin Filament Organization Macromolecule Metabolic Process Protein Phosphorylation Anchoring Junction Negative Regulation Of Supramolecular Fiber Organization Protein Domain Specific Binding Phosphorylation	Regulation Of Biological Quality Regulation Of Transport Regulation Of Signaling Regulation Of Cell Communication Plasma Membrane Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Positive Regulation Of Signaling Signal Transduction Positive Regulation Of Cell Communication Regulation Of System Process Regulation Of Developmental Process Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Transport Regulation Of Cell Differentiation Regulation Of Cellular Component Organization Regulation Of Intracellular Signal Transduction Developmental Process Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Communication Regulation Of Cell Development Regulation Of Membrane Potential Cellular Developmental Process Regulation Of Programmed Cell Death Negative Regulation Of Signaling Calmodulin Binding Focal Adhesion Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Blood Circulation Cytosol Negative Regulation Of Signal Transduction Positive Regulation Of Developmental Process Modulation Of Chemical Synaptic Transmission Positive Regulation Of Metabolic Process Regulation Of Protein Localization Regulation Of Multicellular Organismal Development Regulation Of Vesicle-mediated Transport Protein Kinase Binding Regulation Of Protein Metabolic Process Cell Differentiation Glutamatergic Synapse Cytoplasm Negative Regulation Of Programmed Cell Death Regulation Of Metabolic Process Dendritic Spine
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