PKP2 and DMRTB1

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid, two hybrid)

		PKP2	DMRTB1
Description		plakophilin 2	DMRT like family B with proline rich C-terminal 1
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Intercalated Disc Membrane Cell Junction Desmosome Cell Tip Anchoring Junction	Chromatin Nucleus
	Molecular Function	DNA Binding Protein Kinase C Binding Protein Binding Sodium Channel Regulator Activity Intermediate Filament Binding Transmembrane Transporter Binding Alpha-catenin Binding Cadherin Binding Molecular Adaptor Activity Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Desmosome Assembly Desmosome Organization Cell Adhesion Cell-cell Signaling Heart Development Positive Regulation Of Sodium Ion Transport Regulation Of Cell-substrate Adhesion Intermediate Filament Bundle Assembly Maintenance Of Animal Organ Identity Ventricular Cardiac Muscle Tissue Morphogenesis Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Maintenance Of Protein Localization At Cell Tip Regulation Of Substrate Adhesion-dependent Cell Spreading	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Sex Differentiation
Pathways		Keratinization Formation of the cornified envelope
Drugs
Diseases		Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Atrial fibrillation ( 29892015 30061737) Blood protein levels ( 30072576) Body mass index (change over time) in lung cancer ( 28044437) Methadone dose in opioid dependence ( 28115739) Obesity-related traits ( 23251661) Parkinson's disease ( 27182965 32201043) Periodontal disease related phenotype (PCT5) ( 26962152) Prevalent atrial fibrillation ( 28416818)	Cerebrospinal fluid AB1-42 levels ( 28247064) Response to statin therapy ( 20339536)
Interacting Genes		48 interacting genes: ACTN3 AKAP9 ARMC8 BAG4 CARD9 CASK CCDC120 CCDC125 CCHCR1 CTBP1 CTNNB1 DMRTB1 DSC1 DSC2 DSG1 DSG2 DSP EIF4ENIF1 EXOSC8 FHL3 GOLGA2 GRIPAP1 GTF2IRD1 HOOK2 HSPB2 JUP KLC4 KRT18 KRT31 KRT5 MAGOHB MARK3 MTUS2 NCKIPSD NDEL1 PIBF1 PLEKHG4 POLR3A RABEP1 RBM5 RBPMS ROPN1 SMAD9 SPTA1 TEKT4 VHL VIM YWHAG	90 interacting genes: ALG13 ANKHD1 BAG4 BCAS2 C1orf94 CCND3 CDKN2D CPEB2 CPSF7 CTBP1 CTBP2 EWSR1 EXOSC1 EXOSC5 EXOSC7 EYA2 FXR2 HNRNPUL1 IL16 INCA1 KAT5 KIF21B KRT81 KRTAP19-5 KRTAP19-6 KRTAP21-2 KRTAP8-1 LARP4B LENG8 MAZ MBNL1 MRPL44 MSI2 MTPAP NCKIPSD NEDD9 NIF3L1 NIP7 NXF1 PARD6G PATL1 PEF1 PKP2 PPIL3 PRMT2 PRPF39 PRPF6 PRR3 PRRC2B QKI RAMAC RBFOX1 RBFOX2 RBM14 RBM22 RBM42 RBM7 RBPMS RPA2 RPS28 SECISBP2 SF1 SF3B4 SFPQ SH3RF1 SLAIN1 SLIRP SNRPA SNRPB SNRPC SNRPN SNW1 SORBS3 SRSF2 TENT5A TEX10 TLE5 TNRC6A TOX TRNAU1AP TSG101 TXNL4A UBL5 UNKL VASP WBP4 YTHDF1 YTHDF3 ZC3H10 ZMAT5
Entrez ID		5318	63948
HPRD ID		04177	16828
Ensembl ID		ENSG00000057294	ENSG00000143006
Uniprot IDs		A0A8V8TPU9 A0AAQ5BGY2 Q99959	I6L9A0 Q96MA1
PDB IDs		3TT9
Enriched GO Terms of Interacting Partners?		Desmosome Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Cytoskeleton Organization Cornified Envelope Regulation Of Cardiac Muscle Cell Action Potential Cytoplasm Regulation Of Ventricular Cardiac Muscle Cell Action Potential Desmosome Organization Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Cytoskeleton Regulation Of Action Potential Cytosol Regulation Of Cardiac Muscle Cell Contraction Cell Junction Scaffold Protein Binding Heterotypic Cell-cell Adhesion Microtubule Organizing Center Regulation Of Striated Muscle Contraction Structural Constituent Of Cytoskeleton Regulation Of Heart Rate Cell-cell Junction Organization Organelle Organization Catenin-TCF7L2 Complex Cell-cell Junction Homotypic Cell-cell Adhesion Intracellular Protein Localization Protein Binding Intermediate Filament Organization Cellular Response To Indole-3-methanol Regulation Of Muscle System Process Nucleus Regulation Of Cardiac Muscle Contraction Microtubule Nucleation Cell-cell Adhesion Microtubule-based Process Response To Indole-3-methanol Regulation Of Muscle Contraction Anchoring Junction Fascia Adherens Adherens Junction Focal Adhesion Protein-DNA Complex Regulation Of Heart Contraction	RNA Binding MRNA Processing RNA Processing MRNA Metabolic Process RNA Splicing Nucleic Acid Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Nucleic Acid Metabolic Process Spliceosomal Complex Regulation Of MRNA Metabolic Process Nucleus MRNA Binding Nucleobase-containing Compound Metabolic Process Regulation Of RNA Splicing Nucleoplasm Cytoplasmic Stress Granule Regulation Of MRNA Splicing, Via Spliceosome Protein Binding Regulation Of MRNA Processing U1 SnRNP Macromolecule Metabolic Process U4/U6 X U5 Tri-snRNP Complex Catalytic Step 2 Spliceosome Negative Regulation Of Macromolecule Metabolic Process U2-type Prespliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Metabolic Process U5 SnRNP Spliceosomal Complex Assembly Negative Regulation Of Metabolic Process U2-type Precatalytic Spliceosome Negative Regulation Of RNA Metabolic Process Protein-RNA Complex Assembly Transcription Corepressor Activity Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Membraneless Organelle Assembly Nucleolar Exosome (RNase Complex) Negative Regulation Of MRNA Metabolic Process U2-type Catalytic Step 2 Spliceosome Intermediate Filament Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Ribonucleoprotein Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cytoplasm Regulation Of Metabolic Process Cytoplasmic Exosome (RNase Complex)
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