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YWHAG and PHLDB2
Number of citations of the paper that reports this interaction (PMID
15324660
)
121
Data Source:
HPRD
(in vivo)
YWHAG
PHLDB2
Gene Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
pleckstrin homology-like domain, family B, member 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Focal Adhesion
Membrane
Cytoplasmic Vesicle Membrane
Extracellular Vesicular Exosome
Cytoplasm
Plasma Membrane
Intermediate Filament Cytoskeleton
Molecular Function
Protein Kinase C Binding
Insulin-like Growth Factor Receptor Binding
Protein Binding
Protein Kinase C Inhibitor Activity
Protein Domain Specific Binding
Receptor Tyrosine Kinase Binding
Poly(A) RNA Binding
Protein Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Negative Regulation Of Protein Kinase Activity
Protein Targeting
Apoptotic Process
Organelle Organization
Regulation Of Signal Transduction
Cellular Response To Insulin Stimulus
Regulation Of Neuron Differentiation
Regulation Of Synaptic Plasticity
Membrane Organization
Negative Regulation Of Protein Serine/threonine Kinase Activity
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways
Organelle biogenesis and maintenance
Translocation of GLUT4 to the plasma membrane
Activation of BH3-only proteins
Assembly of the primary cilium
G2/M Transition
Regulation of PLK1 Activity at G2/M Transition
Anchoring of the basal body to the plasma membrane
Cell Cycle, Mitotic
Activation of BAD and translocation to mitochondria
Loss of proteins required for interphase microtubule organization from the centrosome
Loss of Nlp from mitotic centrosomes
Programmed Cell Death
Centrosome maturation
Mitotic G2-G2/M phases
Recruitment of mitotic centrosome proteins and complexes
Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS
Multiple sclerosis (
21654844
)
Cognitive performance (
20125193
)
Protein-Protein Interactions
285 interactors:
ABL1
ABLIM1
ACIN1
AKAP13
AKT1S1
ALB
ANKHD1-EIF4EBP3
ANKS1A
APP
ARAF
ARHGEF2
ARHGEF6
ARHGEF7
ATP5A1
ATP5B
ATP6V0B
BAD
BAIAP2
BAIAP2L1
BCLAF1
BCR
BRAF
C1QBP
CAD
CAMKK1
CASP3
CBL
CCNY
CCS
CCT2
CDC5L
CDK11B
CDK16
CDK17
CDKN1B
CENPJ
CEP170
CEP250
CEP95
CFAP20
CFL1
CGN
CGNL1
CHAF1A
CHEK1
CKAP2
CLASP1
CLINT1
CLK1
CLK2
CLK3
CLTC
COPS5
CPSF3
CRTC1
CRTC2
CRTC3
CSE1L
CTNND1
CTPS1
CYFIP2
DCAF7
DCP1A
DDX17
DDX27
DDX39B
DENND4A
DFFA
DHX15
DISC1
DOCK7
DYNC1H1
DYRK1A
EDC3
EEF1A1
EEF1G
EML3
EPB41L2
EPB41L3
EPN2
ERC1
EWSR1
EXO1
FAM13B
FAM53C
FAM65B
FARP2
FGD6
FLNA
FOXO1
FOXO3
GBF1
GIT1
GIT2
GSK3A
GTPBP4
HDAC4
HDAC7
HECTD1
HIST1H3A
HIVEP2
HNRNPAB
HNRNPH1
HNRNPM
HOXC10
HSPA1A
HSPA8
HSPA9
HSPB6
HSPD1
IGF1R
IL7R
ING1
INPP5E
IRS1
IRS2
IRS4
JAKMIP1
KAT5
KCNK15
KCNK3
KCNK9
KIAA0408
KIAA0930
KIF1B
KIF1C
KIF23
KIF5B
KIF5C
KLC2
KLC3
KRT18
LARP1
LATS2
LBR
LIMA1
LMO7
LRCH3
LSR
LTB4R
LUC7L2
LUC7L3
MAGOHB
MAP3K2
MAP3K3
MAPKAP1
MARK3
MCM5
MDM4
MFAP1
MICALL1
MIEF1
MLLT4
MPHOSPH9
MPRIP
MSL2
MYCBP2
MYH10
N4BP3
NCKAP1
NCKIPSD
NDE1
NDEL1
NEDD4L
NEFL
NOLC1
NUFIP2
NUMBL
OSBPL3
P4HB
PABPC1
PAK1
PAK4
PARD3
PARD3B
PFKFB2
PGAM5
PHLDB2
PI4KB
PIK3C3
PIK3R1
PKP2
PLA2G12A
PLEKHA5
PNN
POT1
PPFIA1
PPFIBP1
PPIG
PPP1R12A
PPP6R3
PRKCA
PRKCB
PRKCD
PRKCG
PRKCQ
PRKDC
PRLR
PRMT1
PRMT5
PRPF38B
PRPF40A
PRPF4B
PTPN14
PTPN3
PUF60
RAB11A
RAB11FIP2
RAB11FIP5
RABEP1
RACGAP1
RAF1
RAI14
RALGPS2
RAPGEF6
RASAL2
RASSF8
RGS12
RMDN3
RNPS1
RPS2
RRM1
SAMD4A
SAMD4B
SF3B3
SFN
SH3BP4
SH3BP5L
SHKBP1
SHPRH
SHROOM2
SIMC1
SLC25A3
SMARCD1
SNRNP200
SON
SPTBN1
SRC
SRGAP2
SRPK1
SRRM1
SRRM2
SRSF10
SRSF3
SSFA2
SVIL
SYNPO
SYNPO2
TAB1
TAF15
TBC1D1
TBC1D4
TERF1
TFE3
THRAP3
TIAM1
TINF2
TJP2
TMEM102
TNFAIP3
TP53
TP53BP2
TRA2A
TRA2B
TSC1
TSC2
TUBA4A
TUBB
TUBB4A
UBC
UCP2
UCP3
USP37
USP8
WEE1
WNK1
WWTR1
YAP1
YWHAB
YWHAE
YWHAH
YWHAQ
ZAK
ZBTB21
ZFP36
4 interactors:
FLNC
USP7
YWHAG
YWHAQ
Entrez ID
7532
90102
HPRD ID
05639
06611
Ensembl ID
ENSG00000170027
ENSG00000144824
Uniprot IDs
P61981
E9PGF6
Q86SQ0
PDB IDs
2B05
3UZD
4E2E
4J6S
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Metabolic Process
Regulation Of Cellular Component Organization
Cell Death
Apoptotic Process
Programmed Cell Death
Death
Cellular Component Assembly
RNA Splicing
Organelle Organization
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Metabolic Process
MRNA Metabolic Process
MRNA Processing
Neurotrophin Signaling Pathway
Cell Cycle
Regulation Of Signaling
Cellular Process
Regulation Of Cellular Process
Cellular Response To Growth Factor Stimulus
Mitotic Cell Cycle
Cellular Localization
RNA Processing
Mitotic Cell Cycle Process
Regulation Of Signal Transduction
Response To Growth Factor
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Apoptotic Process
Fc Receptor Signaling Pathway
Regulation Of Catalytic Activity
Positive Regulation Of Catalytic Activity
Regulation Of Cell Death
Response To Organic Substance
Cell Cycle Process
Cellular Response To Organic Substance
Establishment Of Localization In Cell
System Development
Regulation Of Cell Cycle
Fibroblast Growth Factor Receptor Signaling Pathway
Developmental Process
MRNA Splicing, Via Spliceosome
Regulation Of Organelle Organization
Cell Communication
RNA Splicing, Via Transesterification Reactions
Cellular Response To Stimulus
Signaling
Response To Stimulus
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Positive Regulation Of Mitochondrion Organization
Regulation Of Mitochondrion Organization
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Intracellular Transport
Maintenance Of DNA Methylation
Apoptotic Signaling Pathway
Positive Regulation Of Organelle Organization
Protein Targeting
Regulation Of Intracellular Transport
Developmental Process
Histone Deubiquitination
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Regulation Of Establishment Of Protein Localization
Positive Regulation Of Transport
Substantia Nigra Development
Regulation Of Protein Localization
Transcription-coupled Nucleotide-excision Repair
Membrane Organization
Muscle Fiber Development
Intracellular Protein Transport
Regulation Of Organelle Organization
Tagcloud
?
7q11
atypical
autism
autistic
baz1b
beuren
carry
centromeric
deletions
epilepsy
excludes
flanking
fzd9
haploinsufficiency
hemizygous
hip1
huntingtin
mb
monooxigenase
monooxygenase
multisystemic
neuropsychological
preservation
shed
spanning
svas
tryptophan
wbs
williams
Tagcloud (Difference)
?
7q11
atypical
autism
autistic
baz1b
beuren
carry
centromeric
deletions
epilepsy
excludes
flanking
fzd9
haploinsufficiency
hemizygous
hip1
huntingtin
mb
monooxigenase
monooxygenase
multisystemic
neuropsychological
preservation
shed
spanning
svas
tryptophan
wbs
williams
Tagcloud (Intersection)
?