Wiki-Pi
About
Search
People
Updates
Search
YWHAG and NEFL
Number of citations of the paper that reports this interaction (PubMedID
15324660
)
0
Data Source:
HPRD
(in vivo)
YWHAG
NEFL
Description
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
neurofilament light chain
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Cytosol
Focal Adhesion
Membrane
Vesicle
Synapse
Extracellular Exosome
Presynapse
Cytoplasm
Cytosol
Cytoskeleton
Intermediate Filament
Neurofilament
Axon
Growth Cone
Neuromuscular Junction
Cell Projection
Neuron Projection
Intermediate Filament Cytoskeleton
Schaffer Collateral - CA1 Synapse
Cholinergic Synapse
Postsynaptic Intermediate Filament Cytoskeleton
Presynaptic Intermediate Filament Cytoskeleton
Axon Cytoplasm
Molecular Function
RNA Binding
Protein Kinase C Binding
Insulin-like Growth Factor Receptor Binding
Protein Binding
Protein Kinase C Inhibitor Activity
Protein Domain Specific Binding
Receptor Tyrosine Kinase Binding
Identical Protein Binding
Phosphorylation-dependent Protein Binding
Protein Sequestering Activity
Structural Constituent Of Cytoskeleton
Protein Binding
Tubulin Binding
Protein Domain Specific Binding
Protein-macromolecule Adaptor Activity
Identical Protein Binding
Phospholipase Binding
Protein-containing Complex Binding
Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton
Biological Process
Cytoplasmic Translation
Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell
Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell
Negative Regulation Of Protein Kinase Activity
Protein Targeting
Signal Transduction
Intracellular Protein Localization
Regulation Of Signal Transduction
Positive Regulation Of Cell-cell Adhesion
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Nutrient Levels
Cellular Response To Insulin Stimulus
Regulation Of Protein Localization
Cellular Response To Amino Acid Starvation
TORC1 Signaling
Cellular Response To Glucose Starvation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Neuron Differentiation
Negative Regulation Of Translational Initiation
Positive Regulation Of Translational Initiation
Regulation Of Synaptic Plasticity
Protein Stabilization
Negative Regulation Of T Cell Activation
Positive Regulation Of T Cell Activation
Protein Localization To Lysosome
Protein K6-linked Ubiquitination
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Microtubule Cytoskeleton Organization
Axonogenesis
Anterograde Axonal Transport
Retrograde Axonal Transport
Response To Toxic Substance
Peripheral Nervous System Axon Regeneration
Axonal Transport Of Mitochondrion
Spinal Cord Development
Hippocampus Development
Cerebral Cortex Development
Regulation Of Axon Diameter
Neurofilament Bundle Assembly
Locomotion
Response To Peptide Hormone
Intermediate Filament Polymerization Or Depolymerization
Intermediate Filament Organization
Intermediate Filament Bundle Assembly
Neuron Projection Morphogenesis
Positive Regulation Of Axonogenesis
Neuromuscular Process Controlling Balance
Protein Polymerization
Response To Corticosterone
Neurofilament Cytoskeleton Organization
Regulation Of Synapse Maturation
Motor Neuron Apoptotic Process
Postsynaptic Modulation Of Chemical Synaptic Transmission
Postsynaptic Intermediate Filament Cytoskeleton Organization
Response To Sodium Arsenite
Response To Acrylamide
Negative Regulation Of Motor Neuron Apoptotic Process
Pathways
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
AURKA Activation by TPX2
Regulation of localization of FOXO transcription factors
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Transcriptional and post-translational regulation of MITF-M expression and activity
SPOP-mediated proteasomal degradation of PD-L1(CD274)
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Drugs
Diseases
Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS
Multiple sclerosis (
21654844
)
Schizophrenia (
30285260
)
Fear of minor pain (
28701861
)
Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) (
24554482
)
Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) (
24554482
)
Interacting Genes
286 interacting genes:
ABL1
ABLIM1
ACIN1
AFDN
AKAP13
AKT1S1
ALB
ANKHD1-EIF4EBP3
ANKS1A
APP
ARAF
ARHGEF2
ARHGEF6
ARHGEF7
ATP5F1A
ATP5F1B
ATP6V0B
BAD
BAIAP2
BAIAP2L1
BCLAF1
BCR
BRAF
C1QBP
CAD
CAMKK1
CASP3
CBL
CCNY
CCS
CCT2
CDC5L
CDK11B
CDK16
CDK17
CDKN1B
CEP170
CEP250
CEP95
CFAP20
CFL1
CGN
CGNL1
CHAF1A
CHEK1
CKAP2
CLASP1
CLINT1
CLK1
CLK2
CLK3
CLTC
COPS5
CPAP
CPSF3
CRTC1
CRTC2
CRTC3
CSE1L
CTNND1
CTPS1
CYFIP2
DCAF7
DCP1A
DDX17
DDX27
DDX39B
DENND4A
DFFA
DHX15
DISC1
DOCK7
DYNC1H1
DYRK1A
EDC3
EEF1A1
EEF1G
EML3
EPB41L3
EPN2
ERC1
EWSR1
EXO1
FAM13B
FARP2
FGD6
FLNA
FOXO1
FOXO3
GBF1
GIT1
GIT2
GSK3A
GTPBP4
H3C1
HDAC4
HDAC7
HECTD1
HGF
HNRNPAB
HNRNPH1
HNRNPM
HOXC10
HSPA1A
HSPA8
HSPA9
HSPB6
HSPD1
IGF1R
IL7R
ING1
INPP5E
IRS1
IRS2
IRS4
JAKMIP1
KANK1
KAT5
KCNK15
KCNK3
KCNK9
KIAA0408
KIAA0930
KIF1B
KIF1C
KIF23
KIF5B
KIF5C
KLC2
KLC3
KRT18
LARP1
LATS2
LBR
LIMA1
LMO7
LRCH3
LSR
LTB4R
LUC7L2
LUC7L3
MAGOHB
MAP3K2
MAP3K20
MAP3K3
MAPKAP1
MARK3
MCM5
MDM4
MFAP1
MICALL1
MIEF1
MPHOSPH9
MPRIP
MSL2
MYCBP2
MYH10
N4BP3
NCAM2
NCKAP1
NCKIPSD
NDE1
NDEL1
NEDD4L
NEFL
NHSL2
NOLC1
NUFIP2
NUMBL
OSBPL3
P4HB
PABPC1
PAK1
PAK4
PARD3
PARD3B
PFKFB2
PGAM5
PHLDB2
PI4KB
PIK3C3
PIK3R1
PKP2
PLA2G12A
PLEKHA5
PNN
POT1
PPFIA1
PPFIBP1
PPIG
PPP1R12A
PPP6R3
PRKCA
PRKCB
PRKCD
PRKCG
PRKCQ
PRKDC
PRLR
PRMT1
PRMT5
PRP4K
PRPF38B
PRPF40A
PTPN14
PUF60
RAB11FIP2
RAB11FIP5
RABEP1
RACGAP1
RAF1
RAI14
RALGPS2
RAPGEF6
RASAL2
RASSF8
RGS12
RIPK2
RIPOR2
RMDN3
RNPS1
RPS2
RRM1
SAMD4A
SAMD4B
SF3B3
SFN
SH3BP4
SH3BP5L
SHKBP1
SHPRH
SHROOM2
SIMC1
SLC25A3
SMARCD1
SNRNP200
SON
SPOP
SPTBN1
SRC
SRGAP2
SRPK1
SRRM1
SRRM2
SRSF10
SRSF3
STK11
SVIL
SYNPO
SYNPO2
TAB1
TAF15
TBC1D1
TBC1D4
TERF1
TFE3
THRAP3
TIAM1
TINF2
TJP2
TMEM102
TNFAIP3
TP53
TP53BP2
TRA2A
TRA2B
TSC1
TSC2
TUBA4A
TUBB
TUBB4A
UBC
UBE3A
UCP2
UCP3
USP37
USP8
WEE1
WNK1
YAP1
YWHAB
YWHAE
YWHAH
YWHAQ
ZBTB21
ZFP36
55 interacting genes:
BRD7
CCDC13
CCDC172
CCDC33
CCNC
CDK5RAP2
CEP57L1
CHD3
DES
DSCAM
ENKD1
FXR1
GFAP
GOLGA2
GORASP1
GRIN1
HGS
ITSN1
KDM1A
KIFC3
KLC3
KRT13
KRT15
KRT18
MAP2
MTMR2
MTUS2
MYO15B
MYO5A
NDN
NEFH
NEIL3
NEK6
NME7
PDE4DIP
PIAS4
PKN1
PPP1R16B
PPP1R18
PRMT6
RBM11
SHANK3
SKIL
SMYD1
SPTAN1
TERF1
TEX11
TRIM55
TRIM63
TSC1
TXLNB
USHBP1
USP2
VIM
YWHAG
Entrez ID
7532
4747
HPRD ID
05639
01206
Ensembl ID
ENSG00000170027
ENSG00000277586
Uniprot IDs
P61981
P07196
PDB IDs
2B05
3UZD
4E2E
4J6S
4O46
5D3E
6A5S
6BYJ
6BYL
6BZD
6FEL
6GKF
6GKG
6S9K
6SAD
6Y4K
6Y6B
6ZBT
6ZC9
7A6R
7A6Y
Enriched GO Terms of Interacting Partners
?
Cytosol
Cytoplasm
Protein Binding
Regulation Of Supramolecular Fiber Organization
RNA Splicing
Cadherin Binding
Cytoskeleton
Regulation Of Protein Localization
Regulation Of Cellular Component Organization
Regulation Of Organelle Organization
Protein Serine Kinase Activity
ATP Binding
Regulation Of Cytoskeleton Organization
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Regulation Of RNA Splicing
Nucleus
RNA Binding
MRNA Metabolic Process
Nucleotide Binding
Cellular Component Assembly
Focal Adhesion
Intracellular Signal Transduction
Kinase Activity
Organelle Organization
Cytoskeleton Organization
MRNA Splicing, Via Spliceosome
Microtubule
RNA Splicing, Via Transesterification Reactions
Nucleoplasm
Regulation Of MRNA Metabolic Process
Regulation Of MRNA Processing
MRNA Processing
Regulation Of Cell Cycle
Positive Regulation Of Cellular Component Organization
Regulation Of Protein Metabolic Process
Small GTPase Binding
Nuclear Speck
Regulation Of Intracellular Signal Transduction
Regulation Of Apoptotic Process
Protein-containing Complex
Regulation Of Programmed Cell Death
Regulation Of MRNA Splicing, Via Spliceosome
Regulation Of Actin Filament Organization
Macromolecule Metabolic Process
Protein Phosphorylation
Anchoring Junction
Negative Regulation Of Supramolecular Fiber Organization
Protein Domain Specific Binding
Phosphorylation
Cytoskeleton
Microtubule
Microtubule Binding
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Cytoskeleton Organization
Cytoplasm
Intermediate Filament Organization
Organelle Organization
Centrosome
Structural Constituent Of Cytoskeleton
Intermediate Filament
Cell Projection
Microtubule-based Process
Regulation Of Nervous System Development
Microtubule Cytoskeleton Organization
Regulation Of Cellular Component Organization
Neuron Projection
Centrosome Cycle
Intermediate Filament Cytoskeleton
Regulation Of Neurogenesis
Supramolecular Fiber Organization
Regulation Of Developmental Process
Regulation Of Microtubule Polymerization
Regulation Of Neuron Projection Development
Negative Regulation Of Cellular Component Organization
Positive Regulation Of Neurogenesis
Plasma Membrane Bounded Cell Projection Organization
Scaffold Protein Binding
Dendritic Spine
Cell Projection Organization
Microtubule Organizing Center Organization
Gamma-tubulin Binding
Protein Binding
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Regulation Of Supramolecular Fiber Organization
Positive Regulation Of Nervous System Development
Regulation Of Cell Development
Regulation Of Cell Projection Organization
Microtubule Organizing Center
Regulation Of Cell Differentiation
Regulation Of Microtubule Polymerization Or Depolymerization
Regulation Of Organelle Organization
Regulation Of Organelle Transport Along Microtubule
Kinesin Binding
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Regulation Of Protein-containing Complex Assembly
Organelle Assembly
Calmodulin Binding
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?