YWHAG and PABPC1

Number of citations of the paper that reports this interaction (PMID 15324660)
121

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		YWHAG	PABPC1
Gene Name		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma	poly(A) binding protein, cytoplasmic 1
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Gene Ontology Annotations	Cellular Component	Cytosol Focal Adhesion Membrane Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Membrane Ribonucleoprotein Complex Cytoplasmic Ribonucleoprotein Granule Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome
	Molecular Function	Protein Kinase C Binding Insulin-like Growth Factor Receptor Binding Protein Binding Protein Kinase C Inhibitor Activity Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Poly(A) RNA Binding	Nucleotide Binding Protein Binding Protein C-terminus Binding Poly(A) Binding Poly(U) RNA Binding Translation Activator Activity Poly(A) RNA Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Negative Regulation Of Protein Kinase Activity Protein Targeting Apoptotic Process Organelle Organization Regulation Of Signal Transduction Cellular Response To Insulin Stimulus Regulation Of Neuron Differentiation Regulation Of Synaptic Plasticity Membrane Organization Negative Regulation Of Protein Serine/threonine Kinase Activity Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Splicing, Via Spliceosome MRNA Polyadenylation Translation Translational Initiation Gene Expression Gene Silencing By RNA Cellular Protein Metabolic Process Positive Regulation Of Translation MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Pathways		Organelle biogenesis and maintenance Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Assembly of the primary cilium G2/M Transition Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Activation of BAD and translocation to mitochondria Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes Programmed Cell Death Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes Intrinsic Pathway for Apoptosis	Translation initiation complex formation Nonsense-Mediated Decay (NMD) Regulation of mRNA stability by proteins that bind AU-rich elements Deadenylation of mRNA Translation AUF1 (hnRNP D0) destabilizes mRNA L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation-dependent mRNA decay Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Multiple sclerosis ( 21654844)
Protein-Protein Interactions		285 interactors: ABL1 ABLIM1 ACIN1 AKAP13 AKT1S1 ALB ANKHD1-EIF4EBP3 ANKS1A APP ARAF ARHGEF2 ARHGEF6 ARHGEF7 ATP5A1 ATP5B ATP6V0B BAD BAIAP2 BAIAP2L1 BCLAF1 BCR BRAF C1QBP CAD CAMKK1 CASP3 CBL CCNY CCS CCT2 CDC5L CDK11B CDK16 CDK17 CDKN1B CENPJ CEP170 CEP250 CEP95 CFAP20 CFL1 CGN CGNL1 CHAF1A CHEK1 CKAP2 CLASP1 CLINT1 CLK1 CLK2 CLK3 CLTC COPS5 CPSF3 CRTC1 CRTC2 CRTC3 CSE1L CTNND1 CTPS1 CYFIP2 DCAF7 DCP1A DDX17 DDX27 DDX39B DENND4A DFFA DHX15 DISC1 DOCK7 DYNC1H1 DYRK1A EDC3 EEF1A1 EEF1G EML3 EPB41L2 EPB41L3 EPN2 ERC1 EWSR1 EXO1 FAM13B FAM53C FAM65B FARP2 FGD6 FLNA FOXO1 FOXO3 GBF1 GIT1 GIT2 GSK3A GTPBP4 HDAC4 HDAC7 HECTD1 HIST1H3A HIVEP2 HNRNPAB HNRNPH1 HNRNPM HOXC10 HSPA1A HSPA8 HSPA9 HSPB6 HSPD1 IGF1R IL7R ING1 INPP5E IRS1 IRS2 IRS4 JAKMIP1 KAT5 KCNK15 KCNK3 KCNK9 KIAA0408 KIAA0930 KIF1B KIF1C KIF23 KIF5B KIF5C KLC2 KLC3 KRT18 LARP1 LATS2 LBR LIMA1 LMO7 LRCH3 LSR LTB4R LUC7L2 LUC7L3 MAGOHB MAP3K2 MAP3K3 MAPKAP1 MARK3 MCM5 MDM4 MFAP1 MICALL1 MIEF1 MLLT4 MPHOSPH9 MPRIP MSL2 MYCBP2 MYH10 N4BP3 NCKAP1 NCKIPSD NDE1 NDEL1 NEDD4L NEFL NOLC1 NUFIP2 NUMBL OSBPL3 P4HB PABPC1 PAK1 PAK4 PARD3 PARD3B PFKFB2 PGAM5 PHLDB2 PI4KB PIK3C3 PIK3R1 PKP2 PLA2G12A PLEKHA5 PNN POT1 PPFIA1 PPFIBP1 PPIG PPP1R12A PPP6R3 PRKCA PRKCB PRKCD PRKCG PRKCQ PRKDC PRLR PRMT1 PRMT5 PRPF38B PRPF40A PRPF4B PTPN14 PTPN3 PUF60 RAB11A RAB11FIP2 RAB11FIP5 RABEP1 RACGAP1 RAF1 RAI14 RALGPS2 RAPGEF6 RASAL2 RASSF8 RGS12 RMDN3 RNPS1 RPS2 RRM1 SAMD4A SAMD4B SF3B3 SFN SH3BP4 SH3BP5L SHKBP1 SHPRH SHROOM2 SIMC1 SLC25A3 SMARCD1 SNRNP200 SON SPTBN1 SRC SRGAP2 SRPK1 SRRM1 SRRM2 SRSF10 SRSF3 SSFA2 SVIL SYNPO SYNPO2 TAB1 TAF15 TBC1D1 TBC1D4 TERF1 TFE3 THRAP3 TIAM1 TINF2 TJP2 TMEM102 TNFAIP3 TP53 TP53BP2 TRA2A TRA2B TSC1 TSC2 TUBA4A TUBB TUBB4A UBC UCP2 UCP3 USP37 USP8 WEE1 WNK1 WWTR1 YAP1 YWHAB YWHAE YWHAH YWHAQ ZAK ZBTB21 ZFP36	43 interactors: ANAPC5 APBB1 ATXN2 CARM1 CHAF1A CNOT6 CNOT7 CSDE1 EIF4B EIF4G1 EIF4G3 GNB2L1 GSPT1 GSPT2 HBB HNRNPD HNRNPK IL7R ITCH MAPKAPK2 NDRG1 NFX1 PAIP1 PAIP2 PAIP2B PAN2 PAN3 PCBP1 PCBP2 PCSK7 PIN1 PRMT6 PXN RBM4 SREK1 STAU1 SYCP3 SYNCRIP TERT TOB1 U2AF1 WBP4 YWHAG
Entrez ID		7532	26986
HPRD ID		05639	05247
Ensembl ID		ENSG00000170027	ENSG00000070756
Uniprot IDs		P61981	E7EQV3 E7ERJ7 P11940
PDB IDs		2B05 3UZD 4E2E 4J6S	1CVJ 1G9L 1JGN 1JH4 2K8G 2RQG 2RQH 2X04 3KTP 3KTR 3KUI 3KUJ 3KUR 3KUS 3KUT 3PKN 3PTH 4F02 4F25 4F26
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Cellular Component Organization Cell Death Apoptotic Process Programmed Cell Death Death Cellular Component Assembly RNA Splicing Organelle Organization Neurotrophin TRK Receptor Signaling Pathway Regulation Of Metabolic Process MRNA Metabolic Process MRNA Processing Neurotrophin Signaling Pathway Cell Cycle Regulation Of Signaling Cellular Process Regulation Of Cellular Process Cellular Response To Growth Factor Stimulus Mitotic Cell Cycle Cellular Localization RNA Processing Mitotic Cell Cycle Process Regulation Of Signal Transduction Response To Growth Factor Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Apoptotic Process Fc Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Regulation Of Cell Death Response To Organic Substance Cell Cycle Process Cellular Response To Organic Substance Establishment Of Localization In Cell System Development Regulation Of Cell Cycle Fibroblast Growth Factor Receptor Signaling Pathway Developmental Process MRNA Splicing, Via Spliceosome Regulation Of Organelle Organization Cell Communication RNA Splicing, Via Transesterification Reactions Cellular Response To Stimulus Signaling Response To Stimulus	MRNA Metabolic Process MRNA Processing Regulation Of Translation Posttranscriptional Regulation Of Gene Expression RNA Processing Nuclear-transcribed MRNA Poly(A) Tail Shortening RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Metabolic Process MRNA 3'-end Processing Regulation Of Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Expression RNA 3'-end Processing Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Translational Initiation Nitrogen Compound Metabolic Process RNA Splicing Negative Regulation Of Translation Regulation Of Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Metabolic Process Regulation Of Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Catabolic Process Viral Process Posttranscriptional Gene Silencing Regulation Of MRNA Stability Regulation Of RNA Stability Histone H3-R2 Methylation Gene Silencing By RNA Negative Regulation Of Translational Initiation Negative Regulation Of Cellular Metabolic Process Nuclear-transcribed MRNA Catabolic Process, No-go Decay Negative Regulation Of Gene Expression MRNA Stabilization Cellular Macromolecule Biosynthetic Process Negative Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Gene Silencing Gene Silencing By MiRNA
Tagcloud ?		7q11 atypical autism autistic baz1b beuren carry centromeric deletions epilepsy excludes flanking fzd9 haploinsufficiency hemizygous hip1 huntingtin mb monooxigenase monooxygenase multisystemic neuropsychological preservation shed spanning svas tryptophan wbs williams	address adhesion arm comprised coprecipitated cytoplasm cytoplasmic desmoplakin desmosomes destabilized fxr1 g3bp gain mrnas outside particles pkp1 pkp2 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1
Tagcloud (Difference) ?		7q11 atypical autism autistic baz1b beuren carry centromeric deletions epilepsy excludes flanking fzd9 haploinsufficiency hemizygous hip1 huntingtin mb monooxigenase monooxygenase multisystemic neuropsychological preservation shed spanning svas tryptophan wbs williams	address adhesion arm comprised coprecipitated cytoplasm cytoplasmic desmoplakin desmosomes destabilized fxr1 g3bp gain mrnas outside particles pkp1 pkp2 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1
Tagcloud (Intersection) ?