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YWHAG and WEE1
Number of citations of the paper that reports this interaction (PubMedID
15324660
)
0
Data Source:
HPRD
(in vivo)
YWHAG
WEE1
Description
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
WEE1 G2 checkpoint kinase
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Cytosol
Focal Adhesion
Membrane
Vesicle
Synapse
Extracellular Exosome
Presynapse
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Molecular Function
RNA Binding
Protein Kinase C Binding
Insulin-like Growth Factor Receptor Binding
Protein Binding
Protein Kinase C Inhibitor Activity
Protein Domain Specific Binding
Receptor Tyrosine Kinase Binding
Identical Protein Binding
Phosphorylation-dependent Protein Binding
Protein Sequestering Activity
Nucleotide Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Biological Process
Cytoplasmic Translation
Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell
Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell
Negative Regulation Of Protein Kinase Activity
Protein Targeting
Signal Transduction
Intracellular Protein Localization
Regulation Of Signal Transduction
Positive Regulation Of Cell-cell Adhesion
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Nutrient Levels
Cellular Response To Insulin Stimulus
Regulation Of Protein Localization
Cellular Response To Amino Acid Starvation
TORC1 Signaling
Cellular Response To Glucose Starvation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Neuron Differentiation
Negative Regulation Of Translational Initiation
Positive Regulation Of Translational Initiation
Regulation Of Synaptic Plasticity
Protein Stabilization
Negative Regulation Of T Cell Activation
Positive Regulation Of T Cell Activation
Protein Localization To Lysosome
Protein K6-linked Ubiquitination
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
G2/M Transition Of Mitotic Cell Cycle
Microtubule Cytoskeleton Organization
Mitotic Cell Cycle
Nuclear Envelope Organization
Mitotic Nuclear Membrane Disassembly
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Establishment Of Cell Polarity
Positive Regulation Of DNA Replication
Neuron Projection Morphogenesis
Cell Division
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
AURKA Activation by TPX2
Regulation of localization of FOXO transcription factors
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Transcriptional and post-translational regulation of MITF-M expression and activity
SPOP-mediated proteasomal degradation of PD-L1(CD274)
Polo-like kinase mediated events
Cyclin E associated events during G1/S transition
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
Cyclin A:Cdk2-associated events at S phase entry
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Factors involved in megakaryocyte development and platelet production
Drugs
9-HYDROXY-4-PHENYL-6H-PYRROLO[3,4-C]CARBAZOLE-1,3-DIONE
9-HYDROXY-6-(3-HYDROXYPROPYL)-4-(2-METHOXYPHENYL)PYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE
N-[4-(2-CHLOROPHENYL)-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-C]CARBAZOL-9-YL]FORMAMIDE
4-(2-chlorophenyl)-8-(2-hydroxyethyl)-6-methylpyrrolo[3,4-e]indole-1,3(2H,6H)-dione
3-(9-HYDROXY-1,3-DIOXO-4-PHENYL-2,3-DIHYDROPYRROLO[3,4-C]CARBAZOL-6(1H)-YL)PROPANOIC ACID
8-bromo-4-(2-chlorophenyl)-N-(2-hydroxyethyl)-6-methyl-1,3-dioxo-1,2,3,6-tetrahydropyrrolo[3,4-e]indole-7-carboxamide
MK-1775
Fostamatinib
Diseases
GWAS
Multiple sclerosis (
21654844
)
Schizophrenia (
30285260
)
Cutaneous squamous cell carcinoma (
32041948
)
Emphysema annual change measurement in smokers (adjusted lung density) (
31324189
)
Platelet distribution width (
32888494
)
Interacting Genes
286 interacting genes:
ABL1
ABLIM1
ACIN1
AFDN
AKAP13
AKT1S1
ALB
ANKHD1-EIF4EBP3
ANKS1A
APP
ARAF
ARHGEF2
ARHGEF6
ARHGEF7
ATP5F1A
ATP5F1B
ATP6V0B
BAD
BAIAP2
BAIAP2L1
BCLAF1
BCR
BRAF
C1QBP
CAD
CAMKK1
CASP3
CBL
CCNY
CCS
CCT2
CDC5L
CDK11B
CDK16
CDK17
CDKN1B
CEP170
CEP250
CEP95
CFAP20
CFL1
CGN
CGNL1
CHAF1A
CHEK1
CKAP2
CLASP1
CLINT1
CLK1
CLK2
CLK3
CLTC
COPS5
CPAP
CPSF3
CRTC1
CRTC2
CRTC3
CSE1L
CTNND1
CTPS1
CYFIP2
DCAF7
DCP1A
DDX17
DDX27
DDX39B
DENND4A
DFFA
DHX15
DISC1
DOCK7
DYNC1H1
DYRK1A
EDC3
EEF1A1
EEF1G
EML3
EPB41L3
EPN2
ERC1
EWSR1
EXO1
FAM13B
FARP2
FGD6
FLNA
FOXO1
FOXO3
GBF1
GIT1
GIT2
GSK3A
GTPBP4
H3C1
HDAC4
HDAC7
HECTD1
HGF
HNRNPAB
HNRNPH1
HNRNPM
HOXC10
HSPA1A
HSPA8
HSPA9
HSPB6
HSPD1
IGF1R
IL7R
ING1
INPP5E
IRS1
IRS2
IRS4
JAKMIP1
KANK1
KAT5
KCNK15
KCNK3
KCNK9
KIAA0408
KIAA0930
KIF1B
KIF1C
KIF23
KIF5B
KIF5C
KLC2
KLC3
KRT18
LARP1
LATS2
LBR
LIMA1
LMO7
LRCH3
LSR
LTB4R
LUC7L2
LUC7L3
MAGOHB
MAP3K2
MAP3K20
MAP3K3
MAPKAP1
MARK3
MCM5
MDM4
MFAP1
MICALL1
MIEF1
MPHOSPH9
MPRIP
MSL2
MYCBP2
MYH10
N4BP3
NCAM2
NCKAP1
NCKIPSD
NDE1
NDEL1
NEDD4L
NEFL
NHSL2
NOLC1
NUFIP2
NUMBL
OSBPL3
P4HB
PABPC1
PAK1
PAK4
PARD3
PARD3B
PFKFB2
PGAM5
PHLDB2
PI4KB
PIK3C3
PIK3R1
PKP2
PLA2G12A
PLEKHA5
PNN
POT1
PPFIA1
PPFIBP1
PPIG
PPP1R12A
PPP6R3
PRKCA
PRKCB
PRKCD
PRKCG
PRKCQ
PRKDC
PRLR
PRMT1
PRMT5
PRP4K
PRPF38B
PRPF40A
PTPN14
PUF60
RAB11FIP2
RAB11FIP5
RABEP1
RACGAP1
RAF1
RAI14
RALGPS2
RAPGEF6
RASAL2
RASSF8
RGS12
RIPK2
RIPOR2
RMDN3
RNPS1
RPS2
RRM1
SAMD4A
SAMD4B
SF3B3
SFN
SH3BP4
SH3BP5L
SHKBP1
SHPRH
SHROOM2
SIMC1
SLC25A3
SMARCD1
SNRNP200
SON
SPOP
SPTBN1
SRC
SRGAP2
SRPK1
SRRM1
SRRM2
SRSF10
SRSF3
STK11
SVIL
SYNPO
SYNPO2
TAB1
TAF15
TBC1D1
TBC1D4
TERF1
TFE3
THRAP3
TIAM1
TINF2
TJP2
TMEM102
TNFAIP3
TP53
TP53BP2
TRA2A
TRA2B
TSC1
TSC2
TUBA4A
TUBB
TUBB4A
UBC
UBE3A
UCP2
UCP3
USP37
USP8
WEE1
WNK1
YAP1
YWHAB
YWHAE
YWHAH
YWHAQ
ZBTB21
ZFP36
27 interacting genes:
AKT1
BRD8
BRSK1
BRSK2
BTRC
CASP3
CCNA1
CCNB1
CDC14A
CDCA3
CDK1
CDK2
CRK
CSNK2A1
EPS15
ERRFI1
FBXW11
MAILR
NEDD4
PIN1
PLK1
SKP2
SMAD3
SMURF1
YWHAB
YWHAG
YWHAZ
Entrez ID
7532
7465
HPRD ID
05639
01907
Ensembl ID
ENSG00000170027
ENSG00000166483
Uniprot IDs
P61981
P30291
Q86V29
PDB IDs
2B05
3UZD
4E2E
4J6S
4O46
5D3E
6A5S
6BYJ
6BYL
6BZD
6FEL
6GKF
6GKG
6S9K
6SAD
6Y4K
6Y6B
6ZBT
6ZC9
7A6R
7A6Y
1X8B
2IN6
2IO6
2Z2W
3BI6
3BIZ
3CQE
3CR0
5V5Y
5VC3
5VC4
5VC5
5VC6
5VD2
5VD4
5VD5
5VD7
5VD8
5VD9
5VDA
7N3U
8BJU
8WDK
Enriched GO Terms of Interacting Partners
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Cytosol
Cytoplasm
Protein Binding
Regulation Of Supramolecular Fiber Organization
RNA Splicing
Cadherin Binding
Cytoskeleton
Regulation Of Protein Localization
Regulation Of Cellular Component Organization
Regulation Of Organelle Organization
Protein Serine Kinase Activity
ATP Binding
Regulation Of Cytoskeleton Organization
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Regulation Of RNA Splicing
Nucleus
RNA Binding
MRNA Metabolic Process
Nucleotide Binding
Cellular Component Assembly
Focal Adhesion
Intracellular Signal Transduction
Kinase Activity
Organelle Organization
Cytoskeleton Organization
MRNA Splicing, Via Spliceosome
Microtubule
RNA Splicing, Via Transesterification Reactions
Nucleoplasm
Regulation Of MRNA Metabolic Process
Regulation Of MRNA Processing
MRNA Processing
Regulation Of Cell Cycle
Positive Regulation Of Cellular Component Organization
Regulation Of Protein Metabolic Process
Small GTPase Binding
Nuclear Speck
Regulation Of Intracellular Signal Transduction
Regulation Of Apoptotic Process
Protein-containing Complex
Regulation Of Programmed Cell Death
Regulation Of MRNA Splicing, Via Spliceosome
Regulation Of Actin Filament Organization
Macromolecule Metabolic Process
Protein Phosphorylation
Anchoring Junction
Negative Regulation Of Supramolecular Fiber Organization
Protein Domain Specific Binding
Phosphorylation
Cell Cycle G2/M Phase Transition
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Phosphoserine Residue Binding
Protein Modification Process
Post-translational Protein Modification
Regulation Of Cell Cycle
Regulation Of Protein Localization To Nucleus
Regulation Of Protein Stability
Intracellular Signal Transduction
Regulation Of Protein Metabolic Process
Cytosol
Protein Metabolic Process
Organelle Organization
Positive Regulation Of Protein Metabolic Process
Protein Catabolic Process
Cellular Response To Stress
Protein Targeting
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Protein Localization
Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Regulation Of Protein Catabolic Process
Protein Localization To Site Of Double-strand Break
Signal Transduction
G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Metabolic Process
Protein Polyubiquitination
Macromolecule Catabolic Process
Regulation Of Signaling
Cell Cycle G1/S Phase Transition
Protein Ubiquitination
Regulation Of Cell Cycle Phase Transition
Cytoplasm
Microtubule Cytoskeleton Organization
Cell Division
Protein Kinase Binding
Protein Localization To Organelle
Response To Stress
DNA Damage Checkpoint Signaling
Proteasomal Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Peptidyl-serine Phosphorylation
Protein Modification By Small Protein Conjugation
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Mitotic Cell Cycle Phase Transition
Intracellular Protein Localization
Regulation Of Mitotic Cell Cycle
Protein Phosphorylation
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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