PKP2 and DSG2

Number of citations of the paper that reports this interaction (PMID 11790773)
47

Data Source:
HPRD (in vivo, two hybrid)

		PKP2	DSG2
Gene Name		plakophilin 2	desmoglein 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Intercalated Disc Integral Component Of Membrane Cell Junction Desmosome	Plasma Membrane Cell-cell Junction Cell Surface Integral Component Of Membrane Apical Plasma Membrane Lateral Plasma Membrane Desmosome Extracellular Vesicular Exosome
	Molecular Function	Molecular_function Protein Kinase C Binding Protein Binding Sodium Channel Regulator Activity Intermediate Filament Binding Protein Complex Scaffold Ion Channel Binding	Calcium Ion Binding
	Biological Process	Desmosome Assembly Heart Development Negative Regulation Of Cell Proliferation Positive Regulation Of Sodium Ion Transport Gap Junction Assembly Single Organismal Cell-cell Adhesion Negative Regulation Of Cell Migration Adherens Junction Maintenance Intermediate Filament Bundle Assembly Maintenance Of Organ Identity Ventricular Cardiac Muscle Tissue Morphogenesis Lipid Homeostasis Cardiac Muscle Cell Action Potential Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Cell-cell Signaling Involved In Cardiac Conduction Cell Communication By Electrical Coupling Involved In Cardiac Conduction Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Heart Rate By Cardiac Conduction Regulation Of Tight Junction Assembly	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Response To Progesterone Maternal Process Involved In Female Pregnancy Ventricular Cardiac Muscle Cell Action Potential Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Heart Rate By Cardiac Conduction
Pathways			Apoptotic cleavage of cell adhesion proteins Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		15 interactors: CTNNB1 DSC1 DSC2 DSG1 DSG2 DSP JUP KRT18 KRT5 MARK3 MTUS2 NDEL1 POLR3A SMAD9 YWHAG	5 interactors: DSC1 DSC2 JUP PKP2 PKP3
Entrez ID		5318	1829
HPRD ID		04177	00516
Ensembl ID		ENSG00000057294	ENSG00000046604
Uniprot IDs		Q99959	Q14126
PDB IDs		3TT9	2YQG
Enriched GO Terms of Interacting Partners?		Bundle Of His Cell To Purkinje Myocyte Communication Ventricular Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Action Potential Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of Muscle Contraction Cell Adhesion Regulation Of Heart Contraction Cellular Response To Indole-3-methanol Cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Junction Organization Desmosome Organization Single Organismal Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Apoptotic Process Programmed Cell Death Adherens Junction Organization Regulation Of Membrane Potential Cell Death Death Regulation Of Cell Fate Specification Regulation Of Actin Filament-based Process Response To Organic Cyclic Compound Regulation Of Cell Fate Commitment Response To Organic Substance Skin Development Adherens Junction Assembly Cytoskeleton Organization Response To Progesterone Epidermis Development Centrosome Cycle Anatomical Structure Development Cerebral Cortex Radially Oriented Cell Migration Regulation Of Cellular Component Movement Golgi To Plasma Membrane CFTR Protein Transport Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Response To Stimulus Positive Regulation Of Type I Interferon Production	Desmosome Assembly Bundle Of His Cell To Purkinje Myocyte Communication Desmosome Organization Ventricular Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Cell Adhesion Regulation Of Striated Muscle Contraction Action Potential Cell-cell Junction Assembly Single Organismal Cell-cell Adhesion Regulation Of Muscle Contraction Regulation Of Heart Contraction Cell Junction Assembly Cell-cell Junction Organization Regulation Of Membrane Potential Regulation Of Actin Filament-based Process Establishment Of Protein Localization To Plasma Membrane Adherens Junction Organization Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Regulation Of Cellular Component Movement Protein Localization To Plasma Membrane Endothelial Cell-cell Adhesion Adherens Junction Maintenance Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Plasma Membrane Organization Establishment Of Protein Localization To Membrane Cellular Response To Indole-3-methanol Maintenance Of Organ Identity Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Intermediate Filament Bundle Assembly Regulation Of Tight Junction Assembly Cytoskeletal Anchoring At Plasma Membrane Protein Localization To Membrane Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cell Communication By Electrical Coupling Endomembrane System Organization Cell-cell Signaling Involved In Cardiac Conduction Intermediate Filament Organization Regulation Of Cell Fate Specification Cellular Component Assembly Gap Junction Assembly Cellular Component Maintenance Regulation Of Cell Fate Commitment
Tagcloud ?		address adhesion arm comprised coprecipitated cytoplasm cytoplasmic desmoplakin desmosomes destabilized fxr1 g3bp gain mrnas outside pabpc1 particles pkp1 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1	cadherins companion continuity desmocollin desmoglein desmoplakin desmosomal desmosomes displaying dsc1 dsc2 dsc3 dsg1 dsg3 exclusive follicle hair immunopositive mutually ontogenic outer plakoglobin plakophilin practically rood root sheath subinfundibular trichocytes
Tagcloud (Difference) ?		address adhesion arm comprised coprecipitated cytoplasm cytoplasmic destabilized fxr1 g3bp gain mrnas outside pabpc1 particles pkp1 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1	cadherins companion continuity desmocollin desmoglein desmosomal displaying dsc1 dsc2 dsc3 dsg1 dsg3 exclusive follicle hair immunopositive mutually ontogenic outer plakoglobin plakophilin practically rood root sheath subinfundibular trichocytes
Tagcloud (Intersection) ?		desmoplakin desmosomes