PKP2 and DSG2

Number of citations of the paper that reports this interaction (PubMedID 11790773)
0

Data Source:
HPRD (two hybrid, in vivo)

		PKP2	DSG2
Description		plakophilin 2	desmoglein 2
Image
GO Annotations	Cellular Component	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Intercalated Disc Membrane Cell Junction Desmosome Cell Tip Anchoring Junction	Cornified Envelope Cytoplasm Plasma Membrane Cell-cell Junction Cell Surface Intercalated Disc Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Desmosome Extracellular Exosome Anchoring Junction
	Molecular Function	DNA Binding Protein Kinase C Binding Protein Binding Sodium Channel Regulator Activity Intermediate Filament Binding Transmembrane Transporter Binding Alpha-catenin Binding Cadherin Binding Molecular Adaptor Activity Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication	Calcium Ion Binding Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
	Biological Process	Desmosome Assembly Desmosome Organization Cell Adhesion Cell-cell Signaling Heart Development Positive Regulation Of Sodium Ion Transport Regulation Of Cell-substrate Adhesion Intermediate Filament Bundle Assembly Maintenance Of Animal Organ Identity Ventricular Cardiac Muscle Tissue Morphogenesis Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Maintenance Of Protein Localization At Cell Tip Regulation Of Substrate Adhesion-dependent Cell Spreading	Desmosome Organization Purkinje Myocyte Development Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Epithelial To Mesenchymal Transition Response To Progesterone Negative Regulation Of Apoptotic Process Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Cell Adhesion Maternal Process Involved In Female Pregnancy Mesenchymal To Epithelial Transition Stem Cell Proliferation Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Inflammatory Response To Wounding Positive Regulation Of Protein Localization To Cell-cell Junction Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Sprouting Angiogenesis
Pathways		Keratinization Formation of the cornified envelope	Apoptotic cleavage of cell adhesion proteins Keratinization Formation of the cornified envelope RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle
Drugs
Diseases		Arrhythmogenic right ventricular cardiomyopathy (ARVC)	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Atrial fibrillation ( 29892015 30061737) Blood protein levels ( 30072576) Body mass index (change over time) in lung cancer ( 28044437) Methadone dose in opioid dependence ( 28115739) Obesity-related traits ( 23251661) Parkinson's disease ( 27182965 32201043) Periodontal disease related phenotype (PCT5) ( 26962152) Prevalent atrial fibrillation ( 28416818)	Blood protein levels ( 30072576)
Interacting Genes		48 interacting genes: ACTN3 AKAP9 ARMC8 BAG4 CARD9 CASK CCDC120 CCDC125 CCHCR1 CTBP1 CTNNB1 DMRTB1 DSC1 DSC2 DSG1 DSG2 DSP EIF4ENIF1 EXOSC8 FHL3 GOLGA2 GRIPAP1 GTF2IRD1 HOOK2 HSPB2 JUP KLC4 KRT18 KRT31 KRT5 MAGOHB MARK3 MTUS2 NCKIPSD NDEL1 PIBF1 PLEKHG4 POLR3A RABEP1 RBM5 RBPMS ROPN1 SMAD9 SPTA1 TEKT4 VHL VIM YWHAG	5 interacting genes: DSC1 DSC2 JUP PKP2 PKP3
Entrez ID		5318	1829
HPRD ID		04177	00516
Ensembl ID		ENSG00000057294	ENSG00000046604
Uniprot IDs		A0A8V8TPU9 A0AAQ5BGY2 Q99959	A0AAQ5BGT2 Q14126
PDB IDs		3TT9	2YQG 5ERD 5J5J 6QNT 6QNU 6SIT 7A7D 7AGF 7AGG 8QJX 8QJY 8QK3
Enriched GO Terms of Interacting Partners?		Desmosome Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Cytoskeleton Organization Cornified Envelope Regulation Of Cardiac Muscle Cell Action Potential Cytoplasm Regulation Of Ventricular Cardiac Muscle Cell Action Potential Desmosome Organization Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Cytoskeleton Regulation Of Action Potential Cytosol Regulation Of Cardiac Muscle Cell Contraction Cell Junction Scaffold Protein Binding Heterotypic Cell-cell Adhesion Microtubule Organizing Center Regulation Of Striated Muscle Contraction Structural Constituent Of Cytoskeleton Regulation Of Heart Rate Cell-cell Junction Organization Organelle Organization Catenin-TCF7L2 Complex Cell-cell Junction Homotypic Cell-cell Adhesion Intracellular Protein Localization Protein Binding Intermediate Filament Organization Cellular Response To Indole-3-methanol Regulation Of Muscle System Process Nucleus Regulation Of Cardiac Muscle Contraction Microtubule Nucleation Cell-cell Adhesion Microtubule-based Process Response To Indole-3-methanol Regulation Of Muscle Contraction Anchoring Junction Fascia Adherens Adherens Junction Focal Adhesion Protein-DNA Complex Regulation Of Heart Contraction	Desmosome Cornified Envelope Desmosome Organization Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Desmosome Assembly Alpha-catenin Binding Regulation Of Ventricular Cardiac Muscle Cell Action Potential Anchoring Junction Cell-cell Adhesion Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cell-cell Junction Organization Adherens Junction Cell Junction Heterotypic Cell-cell Adhesion Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Cell Adhesion Regulation Of Action Potential Homotypic Cell-cell Adhesion Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Regulation Of Heart Rate Cell Junction Organization Cell-cell Junction Assembly Epithelial Cell-cell Adhesion Regulation Of Muscle Contraction Protein Localization To Plasma Membrane Regulation Of Heart Contraction Cell-cell Junction Protein Localization To Cell Periphery Regulation Of Muscle System Process Regulation Of Blood Circulation Cell Junction Assembly Protein Localization To Membrane Cadherin Binding Regulation Of Actin Filament-based Process Regulation Of Membrane Potential Gamma-catenin-TCF7L2 Complex Localization Within Membrane Cell Adhesion Molecule Binding Maintenance Of Protein Localization At Cell Tip Regulation Of System Process Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Desmosome Maintenance Intermediate Filament Catenin-TCF7L2 Complex
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