PLEKHG4 and TSSK3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLEKHG4	TSSK3
Description		pleckstrin homology and RhoGEF domain containing G4	testis specific serine kinase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Extrinsic Component Of Membrane	Cilium Motile Cilium Sperm Flagellum Cell Projection
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Manganese Ion Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Axon Guidance Regulation Of Small GTPase Mediated Signal Transduction	Protein Phosphorylation Spermatogenesis Spermatid Development Cell Differentiation
Pathways		RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		A body shape index ( 34021172) Heel bone mineral density ( 28869591) High density lipoprotein cholesterol levels ( 33339817) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)	Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		65 interacting genes: A1CF ARHGEF5 ARMC7 BEX2 CCDC120 CCDC187 CDC42 CDKN2C CHIC2 COIL DCUN1D5 DPPA3 DTX2 DUSP13B FAM161A FGD2 GATA3 GCM2 GSTZ1 HCK HOXB9 HOXC8 KRT3 KRT75 MALSU1 MATR3 MDFI METAP1 MSRB3 MTA1 MYEF2 MYOZ1 NATD1 OTX1 PFKFB1 PKP2 PRPF18 PRPF31 PSMB1 RHOA RIN1 SAXO1 SAXO4 SETD5 SH2D4A SHISA6 SIX1 SMCP SMG9 TBC1D22B TBX18 TEKT3 TENT5D TFAP2D TFG TRIM55 TRIM63 TSSK3 TTC23 USP2 VPS37C ZCCHC14 ZNF148 ZNF319 ZNF648	67 interacting genes: ADAMTSL4 ARID5A ATP23 CATSPERT CENPN COXFA4L3 DDIT4L DRG2 ECSIT EFHC2 EYA2 FUT9 GOLGA2 GP2 IKZF3 INCA1 KRT75 KRTAP13-2 KRTAP13-3 LBX1 LHX3 LMO2 LNX1 LZTS2 MBD3L1 MEI4 MRPL28 MSX2 MYOG MYOZ3 NFKBID NME4 OIP5 PBX4 PJA1 PLEKHG4 PPP1R16A PRDM6 RBBP4 RBCK1 REL RIN3 RUSC1 SHISA6 SLAIN1 SMAD4 SPMIP6 STAT5B SYNGAP1 TCF4 TCP10L TEPSIN TGM7 TLE5 TRIM35 TRIM50 TRIM54 TRIM9 TRIP6 UROD USP54 VGLL1 VPS52 YJU2B YPEL3 ZBTB25 ZMYND12
Entrez ID		25894	81629
HPRD ID		10890	09635
Ensembl ID		ENSG00000196155	ENSG00000162526
Uniprot IDs		A0A024R6X4 Q58EX7	Q96PN8
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Regulation Of Podosome Assembly Positive Regulation Of Ureteric Bud Formation	Protein Binding Transcription Regulator Complex
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