PLEKHG4 and DUSP13B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLEKHG4	DUSP13B
Description		pleckstrin homology and RhoGEF domain containing G4	dual specificity phosphatase 13B
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Extrinsic Component Of Membrane	Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity MAP Kinase Phosphatase Activity
	Biological Process	Axon Guidance Regulation Of Small GTPase Mediated Signal Transduction	Protein Dephosphorylation Spermatogenesis Dephosphorylation Negative Regulation Of MAPK Cascade Meiotic Cell Cycle
Pathways		RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		A body shape index ( 34021172) Heel bone mineral density ( 28869591) High density lipoprotein cholesterol levels ( 33339817) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		65 interacting genes: A1CF ARHGEF5 ARMC7 BEX2 CCDC120 CCDC187 CDC42 CDKN2C CHIC2 COIL DCUN1D5 DPPA3 DTX2 DUSP13B FAM161A FGD2 GATA3 GCM2 GSTZ1 HCK HOXB9 HOXC8 KRT3 KRT75 MALSU1 MATR3 MDFI METAP1 MSRB3 MTA1 MYEF2 MYOZ1 NATD1 OTX1 PFKFB1 PKP2 PRPF18 PRPF31 PSMB1 RHOA RIN1 SAXO1 SAXO4 SETD5 SH2D4A SHISA6 SIX1 SMCP SMG9 TBC1D22B TBX18 TEKT3 TENT5D TFAP2D TFG TRIM55 TRIM63 TSSK3 TTC23 USP2 VPS37C ZCCHC14 ZNF148 ZNF319 ZNF648	14 interacting genes: ACVR1 CALCOCO1 CARD9 CCDC85B HOOK2 HSF2BP INCA1 LMNA PLEKHG4 SH2B2 SMURF1 TGFBR1 TRAF1 ZRANB1
Entrez ID		25894	51207
HPRD ID		10890	13251
Ensembl ID		ENSG00000196155	ENSG00000079393
Uniprot IDs		A0A024R6X4 Q58EX7	A0A9L9PXN7 Q6B8I1 Q9UII6
PDB IDs			2GWO 2PQ5 5XJV
Enriched GO Terms of Interacting Partners?		Protein Binding Regulation Of Podosome Assembly Positive Regulation Of Ureteric Bud Formation	Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Activity, Type I SMAD Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Regulation Of Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Activin Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Protein Targeting To Vacuole Involved In Autophagy Negative Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway I-SMAD Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Cell Communication Pharyngeal System Development Regulation Of Signaling Negative Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of DNA-binding Transcription Factor Activity Transforming Growth Factor Beta Binding Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Activin Receptor Signaling Pathway Vacuolar Transport Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Ventricular Septum Morphogenesis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Release Of Cytochrome C From Mitochondria Growth Factor Binding Endocardial Cushion Cell Fate Commitment Signal Transduction Cell Surface Receptor Signaling Pathway Perinuclear Endoplasmic Reticulum Lumen Protein Targeting To Vacuole Regulation Of Neuronal Signal Transduction Engulfment Of Target By Autophagosome Cytosol Positive Regulation Of Epithelial To Mesenchymal Transition Establishment Of Protein Localization To Vacuole Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Determination Of Dorsal Identity Positive Regulation Of Neurofibrillary Tangle Assembly
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