HOXB6 and ALX4

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		HOXB6	ALX4
Description		homeobox B6	ALX homeobox 4
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Erythrocyte Homeostasis Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development	Skeletal System Development Hair Follicle Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Muscle Organ Development Post-embryonic Development Anterior/posterior Pattern Specification Limb Morphogenesis Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development Digestive Tract Development Neuron Development Embryonic Skeletal System Morphogenesis Skeletal System Morphogenesis Roof Of Mouth Development
Pathways
Drugs
Diseases			Enlarged parietal foramina/cranium bifidum Frontonasal dysplasia
GWAS		Childhood body mass index ( 26604143) Hemoglobin ( 32888494)	Blood pressure measurement (high sodium intervention) ( 24165912) Brain morphology (MOSTest) ( 32665545) Cadmium levels ( 26025379) Excessive hairiness ( 29895819) ghrelin levels ( 33852427) Gout ( 22179738) Male-pattern baldness ( 27182965 29146897) Monobrow ( 27182965) Response to antidepressants in depression ( 29998114) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)
Interacting Genes		17 interacting genes: ALX4 CLK3 CREBBP CSNK2B EP300 GYS1 HOXB7 KRT15 NEK6 NTAQ1 PKNOX1 PLSCR1 SAT1 SRPK2 TCEAL1 TCF21 TEKT5	14 interacting genes: ALX1 CEBPE EMX1 FOXA3 GATA4 HOXA3 HOXB13 HOXB6 HOXD3 IQUB LEF1 PARVG SOX10 SOX2
Entrez ID		3216	60529
HPRD ID		00849	05661
Ensembl ID		ENSG00000108511	ENSG00000052850
Uniprot IDs		P17509	Q9H161
PDB IDs			2M0C 8OSB
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K27 Acetyltransferase Activity Chromatin Peptide Lactyltransferase (CoA-dependent) Activity Nucleus Negative Regulation Of Viral Process N-terminal Protein Amino Acid Acetylation Peptidyl-lysine Acetylation Regulation Of Cellular Response To Heat Positive Regulation Of Transcription By RNA Polymerase II Acetyltransferase Activity Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Viral Life Cycle Angiogenesis Histone Acetyltransferase Complex Embryonic Organ Morphogenesis Nucleoplasm Anatomical Structure Morphogenesis Protein-lysine-acetyltransferase Activity Nuclear Androgen Receptor Binding Protein Phosphorylation Regulation Of Viral Process Acyltransferase Activity Phosphorylation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Histone Acetyltransferase Activity Protein Acetylation Regulation Of Androgen Receptor Signaling Pathway Protein Modification Process Protein Serine/threonine Kinase Activity Anterior/posterior Pattern Specification Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transferase Activity Embryonic Morphogenesis RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Tau Protein Binding Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity	Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II Regionalization DNA Binding Anterior/posterior Pattern Specification Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Pattern Specification Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Anatomical Structure Morphogenesis Regulation Of RNA Metabolic Process Gland Development Regulation Of Nucleobase-containing Compound Metabolic Process Embryonic Skeletal System Morphogenesis Embryonic Morphogenesis Sequence-specific DNA Binding Transcription Cis-regulatory Region Binding Skeletal System Morphogenesis Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Morphogenesis Regulation Of Macromolecule Biosynthetic Process Embryonic Organ Morphogenesis Glossopharyngeal Nerve Morphogenesis Regulation Of Primary Metabolic Process Developmental Process Animal Organ Development Regulation Of Macromolecule Metabolic Process DNA-templated Transcription Cellular Developmental Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Regulator Complex Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Radial Glial Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Cranial Nerve Morphogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Glial Cell Differentiation Nucleus System Development Morphogenesis Of An Epithelium RNA Polymerase II Transcription Regulator Complex
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