TLX1

Description		T cell leukemia homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development
Pathways
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Regular attendance at a pub or social club ( 29970889)
Interacting Genes		11 interacting genes: CTF1 EIF4E MEIS1 MEIS2 NFIC PKNOX1 PPP1CB PPP1CC PPP2CA PPP2CB TLE1
Entrez ID		3195
HPRD ID		01728
Ensembl ID		ENSG00000107807
Uniprot IDs		P31314
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Phosphoprotein Phosphatase Activity Dephosphorylation Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process PTW/PP1 Phosphatase Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein Phosphatase Type 2A Complex FAR/SIN/STRIPAK Complex Eye Development Response To Lead Ion Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Chromosome, Centromeric Region Sensory Organ Development Animal Organ Morphogenesis Chromatin Nucleus Tau Protein Binding Transcription Regulator Complex Developmental Process Eukaryotic Initiation Factor 4G Binding Negative Regulation Of Cell Differentiation Embryonic Pattern Specification Glycogen Metabolic Process Myosin-light-chain-phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Transcription By RNA Polymerase II Regulation Of Microtubule Polymerization Circadian Regulation Of Gene Expression Negative Regulation Of Neuron Differentiation Response To Light Stimulus Energy Reserve Metabolic Process Polysaccharide Metabolic Process Phosphatase Activity Leukemia Inhibitory Factor Receptor Binding RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Neuron Differentiation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Cell Population Proliferation Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Cell Differentiation Positive Regulation Of Cardiac Muscle Myoblast Proliferation Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Developmental Process
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