TLX1 and MEIS1

Number of citations of the paper that reports this interaction (PMID 11342305)
11

Data Source:
HPRD (in vitro)

		TLX1	MEIS1
Gene Name		T-cell leukemia homeobox 1	Meis homeobox 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Transcription Factor Complex
	Molecular Function	Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Central Nervous System Development Positive Regulation Of Cell Proliferation Neuron Differentiation Cell Fate Commitment Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Organ Formation	Angiogenesis Lens Morphogenesis In Camera-type Eye Transcription From RNA Polymerase II Promoter Megakaryocyte Development Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Definitive Hemopoiesis
Pathways
Drugs
Diseases
GWAS			PR interval ( 20062060 23139255) Restless legs syndrome ( 17637780 21779176)
Protein-Protein Interactions		8 interactors: MEIS1 NFIC PKNOX1 PPP1CB PPP1CC PPP2CA PPP2CB TLE1	27 interactors: EMX2 ETS1 HOXA10 HOXA11 HOXA13 HOXA2 HOXA5 HOXA7 HOXA9 HOXB1 HOXB13 HOXB4 HOXB8 HOXC11 HOXC13 HOXD11 HOXD12 HOXD13 HOXD4 HOXD9 PBX1 PBX3 PKNOX1 TLX1 TLX2 TLX3 TRMT10B
Entrez ID		3195	4211
HPRD ID		01728	03442
Ensembl ID		ENSG00000107807	ENSG00000143995
Uniprot IDs		P31314	F5GYS8 F8W8U3 O00470
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Dephosphorylation Regulation Of Gene Expression Dephosphorylation Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Entrainment Of Circadian Clock By Photoperiod Triglyceride Catabolic Process Cellular Response To Growth Factor Stimulus Photoperiodism Entrainment Of Circadian Clock Response To Growth Factor Acylglycerol Catabolic Process Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Enzyme Linked Receptor Protein Signaling Pathway Glycogen Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Circadian Regulation Of Gene Expression Polysaccharide Metabolic Process Regulation Of Circadian Rhythm Triglyceride Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Neutral Lipid Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Energy Reserve Metabolic Process Positive Regulation Of Gene Expression Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Lipid Catabolic Process Cellular Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Circadian Rhythm Regulation Of Signaling Mitotic Cell Cycle Cell Surface Receptor Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Fibroblast Growth Factor Stimulus RNA Metabolic Process Catabolic Process Response To Transforming Growth Factor Beta Response To Fibroblast Growth Factor Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Regulation Of Glycogen Catabolic Process Positive Regulation Of Metabolic Process Gene Expression	Anterior/posterior Pattern Specification Pattern Specification Process Embryonic Morphogenesis Transcription, DNA-templated Skeletal System Development Embryonic Skeletal System Development RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Anatomical Structure Morphogenesis Multicellular Organismal Development System Development Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Embryonic Skeletal System Morphogenesis RNA Metabolic Process Limb Development Embryo Development Gene Expression Organ Development Developmental Process Organ Morphogenesis Embryonic Limb Morphogenesis Cellular Macromolecule Biosynthetic Process Anatomical Structure Development Macromolecule Biosynthetic Process Limb Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Proximal/distal Pattern Formation Positive Regulation Of Transcription, DNA-templated Skeletal System Morphogenesis Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Embryonic Organ Morphogenesis Regulation Of Metabolic Process Embryonic Organ Development Cellular Nitrogen Compound Metabolic Process Chordate Embryonic Development Nitrogen Compound Metabolic Process Embryo Development Ending In Birth Or Egg Hatching Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Embryonic Forelimb Morphogenesis
Tagcloud ?		anlage asplenia attributable circulation conditional cre creer crossed descendants engineered erythrocytes extramedullary governing hematopoiesis immunological knock lineage manipulation mesenchymal mesenchyme microenvironment niche recapitulates serves spleen t2 tamoxifen tracing venus	acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes kat6a localizes lymphoma maintain maintaining maintains malignancy menin mll1 moz myst3 ncoa3 overlap progenitor progenitors proliferative tale tif2 translocations
Tagcloud (Difference) ?		anlage asplenia attributable circulation conditional cre creer crossed descendants engineered erythrocytes extramedullary governing hematopoiesis immunological knock lineage manipulation mesenchymal mesenchyme microenvironment niche recapitulates serves spleen t2 tamoxifen tracing venus	acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes kat6a localizes lymphoma maintain maintaining maintains malignancy menin mll1 moz myst3 ncoa3 overlap progenitor progenitors proliferative tale tif2 translocations
Tagcloud (Intersection) ?