RALY and GTPBP3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RALY	GTPBP3
Description		RALY heterogeneous nuclear ribonucleoprotein	GTP binding protein 3, mitochondrial
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Spliceosomal Complex Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Nucleus Cytoplasm Mitochondrion Transferase Complex
	Molecular Function	Nucleic Acid Binding Transcription Coregulator Activity RNA Binding Protein Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity TRNA 5-taurinomethyluridine Synthase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Cholesterol Homeostasis	TRNA Wobble Uridine Modification TRNA Modification TRNA Processing TRNA Methylation Mitochondrial TRNA Wobble Uridine Modification
Pathways			tRNA modification in the mitochondrion
Drugs
Diseases
GWAS		Adult body size ( 32376654) Basal cell carcinoma ( 33549134 27539887 31174203) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 22976474) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Cutaneous malignant melanoma ( 32341527) Cutaneous squamous cell carcinoma ( 32041948) Estimated glomerular filtration rate ( 31451708) Facial pigmentation ( 25705849) Hair color ( 29662168) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Idiopathic dilated cardiomyopathy ( 29495422) Keratinocyte cancer (MTAG) ( 31174203) Low tan response ( 29739929) Melanoma ( 28212542) Nevus count or cutaneous melanoma ( 32341527) Non-melanoma skin cancer ( 29739929) Red cell distribution width ( 32888494) Red vs. brown/black hair color ( 30531825) Refractive error ( 32231278) Skin colour saturation ( 25963972) Skin sensitivity to sun ( 25963972) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Squamous cell carcinoma ( 26829030) Type 2 diabetes ( 30297969) Vitiligo ( 27723757) Weight ( 28552196) Youthful appearance (self-reported) ( 32339537)	Mitochondrial DNA copy number ( 30704525)
Interacting Genes		30 interacting genes: BCCIP BYSL CELF1 EXOC7 GTPBP3 HNRNPD HNRNPH1 HNRNPK HSF2BP KHDRBS1 LNX1 MDM2 MRPL38 MTUS2 PCBP1 PIK3CD PLOD3 PRKN QKI RBPMS2 RPL9 SDCBP SPG7 THAP1 TIGD3 USP7 WDR62 ZBTB24 ZNF408 ZNF76	29 interacting genes: BEND7 CAPN3 CCDC32 CIC COPS5 DCAF8 DPPA4 GNE INCA1 ITGB3BP MBD3L1 MEOX2 MESD OGT PARP11 PFKL POLDIP3 PPP1R18 PRPF3 PTAFR RALY RIBC2 SERTAD3 SINHCAF TBC1D3B TBC1D3G ZFP90 ZNF69 ZNF774
Entrez ID		22913	84705
HPRD ID		11480	12255
Ensembl ID		ENSG00000125970	ENSG00000130299
Uniprot IDs		Q53GL6 Q9UKM9	B7Z563 Q969Y2
PDB IDs		1WF1
Enriched GO Terms of Interacting Partners?		Nucleic Acid Binding MRNA Binding Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Ribonucleoprotein Complex Regulation Of MRNA Processing Response To Ether Nucleic Acid Metabolic Process RNA Metabolic Process Nucleus Regulation Of MRNA Metabolic Process Cytoplasmic Stress Granule RNA Binding Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Retrograde Transport, Endosome To Golgi RNA Processing Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Telomere Capping Positive Regulation Of Catabolic Process Regulation Of Exosomal Secretion Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Poly(U) RNA Binding Protein Binding Negative Regulation Of MRNA Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Postsynaptic Density Regulation Of Macromolecule Biosynthetic Process MRNA Processing SH3 Domain Binding Positive Regulation Of MRNA Catabolic Process Cytosol Cytoplasm Regulation Of Primary Metabolic Process Amyloid Fibril Formation Regulation Of Intracellular Transport Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Hepatocyte Dedifferentiation Cellular Response To Putrescine Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Formaldehyde Cellular Response To Vitamin B1
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