RALY and SPG7

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RALY	SPG7
Gene Name		RALY heterogeneous nuclear ribonucleoprotein	spastic paraplegia 7 (pure and complicated autosomal recessive)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Catalytic Step 2 Spliceosome	Mitochondrion Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding Poly(A) RNA Binding	Metalloendopeptidase Activity Protein Binding ATP Binding Peptidase Activity Zinc Ion Binding Unfolded Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome	Proteolysis Mitochondrion Organization Nervous System Development Anterograde Axon Cargo Transport
Pathways
Drugs
Diseases
GWAS		Breast cancer ( 22976474)
Protein-Protein Interactions		11 interactors: CELF1 HNRNPC HNRNPD HNRNPH1 HNRNPK KHDRBS1 PCBP1 PIK3CD QKI SPG7 WDR62	23 interactors: CCNDBP1 HNRNPK KHDRBS2 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP4-12 LRIF1 LZTS2 MAPK6 MDFI MTUS2 NOTCH2NL PLSCR1 PNMA1 PSME3 PSTPIP1 RALY RBPMS SPATS1 STAMBP TRIM28
Entrez ID		22913	6687
HPRD ID		11480	04149
Ensembl ID		ENSG00000125970	ENSG00000197912
Uniprot IDs		Q53GL6 Q9UKM9	Q9UQ90
PDB IDs		1WF1	2QZ4
Enriched GO Terms of Interacting Partners?		MRNA Processing MRNA Metabolic Process RNA Processing RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Posttranscriptional Regulation Of Gene Expression Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Translation RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Translation Nitrogen Compound Metabolic Process Positive Regulation Of RNA Export From Nucleus Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter 3'-UTR-mediated MRNA Destabilization Regulation Of RNA Splicing Mast Cell Differentiation Natural Killer Cell Chemotaxis B Cell Chemotaxis Spermatid Development Neutrophil Extravasation Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Mast Cell Chemotaxis Regulation Of Protein Metabolic Process Spermatid Differentiation Respiratory Burst Involved In Defense Response Regulation Of Gene Expression Circadian Regulation Of Translation MRNA Destabilization Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Gene Expression T Cell Chemotaxis Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor Biosynthetic Process 3'-UTR-mediated MRNA Stabilization RNA Destabilization Germ Cell Development Respiratory Burst Regulation Of RNA Export From Nucleus Positive Regulation Of Translational Initiation Long-chain Fatty Acid Biosynthetic Process RNA Interference Regulation Of Receptor Biosynthetic Process Lymphocyte Chemotaxis	Regulation Of Protein Localization To Nucleus Regulation Of Protein Import Into Nucleus Negative Regulation Of Wnt Signaling Pathway Regulation Of Cellular Process Regulation Of Nucleocytoplasmic Transport Regulation Of Intracellular Protein Transport Gene Expression Regulation Of Wnt Signaling Pathway Negative Regulation Of Viral Process Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of DNA Demethylation Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Regulation Of Protein Localization Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Cytokinesis Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Embryonic Placenta Development Transcription, DNA-templated Inflammatory Response Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Regulation Of Intracellular Transport RNA Metabolic Process RNA Biosynthetic Process Convergent Extension Involved In Axis Elongation Regulation Of Genetic Imprinting Phosphatidylserine Biosynthetic Process DNA Methylation Involved In Embryo Development Regulation Of Cellular Localization Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Viral Process Response To Stimulus Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Intracellular Protein Transport RNA Processing Negative Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor Biosynthetic Process Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Spindle Midzone Assembly Placenta Development Positive Regulation Of Protein Metabolic Process Phospholipid Scrambling Regulation Of Protein Transport
Tagcloud ?		asip avian birds buds chickens color document dorsoventral eif2b encompasses feather hair implying lethal mammals melanin patterning pigmentation places quail quails remarkable similarities skins slc24a5 universal ventral vertebrates yellow	ablated accumulates axons biogenesis corticospinal defines exposes hereditary implication isoform knock lacks limbs lumen microsomal name owing paraplegia paraplegin performs proteases recessive resides retina retrograde spastic spasticity usage weakness
Tagcloud (Difference) ?		asip avian birds buds chickens color document dorsoventral eif2b encompasses feather hair implying lethal mammals melanin patterning pigmentation places quail quails remarkable similarities skins slc24a5 universal ventral vertebrates yellow	ablated accumulates axons biogenesis corticospinal defines exposes hereditary implication isoform knock lacks limbs lumen microsomal name owing paraplegia paraplegin performs proteases recessive resides retina retrograde spastic spasticity usage weakness
Tagcloud (Intersection) ?