RALY and WDR62

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		RALY	WDR62
Name		RALY heterogeneous nuclear ribonucleoprotein	WD repeat domain 62
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Spliceosomal Complex Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Spindle Pole Nucleus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Centriolar Satellite
	Molecular Function	Nucleic Acid Binding Transcription Coregulator Activity RNA Binding Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Cholesterol Homeostasis	Positive Regulation Of Neuroblast Proliferation Mitotic Spindle Organization Centriole Replication Nervous System Development Cerebral Cortex Development Neurogenesis Regulation Of Neuron Differentiation Regulation Of Centrosome Cycle Positive Regulation Of Neuron Migration
GWAS		Adult body size ( 32376654 ) Basal cell carcinoma ( 33549134 27539887 31174203 ) Blond vs. brown/black hair color ( 30531825 ) Breast cancer ( 22976474 ) Cancer ( 27197191 ) Cancer (pleiotropy) ( 27197191 ) Cutaneous malignant melanoma ( 32341527 ) Cutaneous squamous cell carcinoma ( 32041948 ) Estimated glomerular filtration rate ( 31451708 ) Facial pigmentation ( 25705849 ) Hair color ( 29662168 ) HDL cholesterol levels ( 32203549 ) Hip circumference adjusted for BMI ( 34021172 ) Idiopathic dilated cardiomyopathy ( 29495422 ) Keratinocyte cancer (MTAG) ( 31174203 ) Low tan response ( 29739929 ) Melanoma ( 28212542 ) Nevus count or cutaneous melanoma ( 32341527 ) Non-melanoma skin cancer ( 29739929 ) Red cell distribution width ( 32888494 ) Red vs. brown/black hair color ( 30531825 ) Refractive error ( 32231278 ) Skin colour saturation ( 25963972 ) Skin sensitivity to sun ( 25963972 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Squamous cell carcinoma ( 26829030 ) Type 2 diabetes ( 30297969 ) Vitiligo ( 27723757 ) Weight ( 28552196 ) Youthful appearance (self-reported) ( 32339537 )	No GWAS studies recorded
Interacting Genes		30 interacting genes: BCCIP BYSL CELF1 EXOC7 GTPBP3 HNRNPD HNRNPH1 HNRNPK HSF2BP KHDRBS1 LNX1 MDM2 MRPL38 MTUS2 PCBP1 PIK3CD PLOD3 PRKN QKI RBPMS2 RPL9 SDCBP SPG7 THAP1 TIGD3 USP7 WDR62 ZBTB24 ZNF408 ZNF76	10 interacting genes: DYRK2 ENKD1 LRIF1 MAGEB4 MAPK8 MAPK9 P4HA3 RALY TBC1D23 TBP
Entrez ID		22913	284403
HPRD ID		11480	10721
Ensembl ID		ENSG00000125970	ENSG00000075702
Uniprot IDs		Q53GL6 Q9UKM9	A0A7P0T9D9 A0A7P0TAK3 A0A7P0Z436 O43379
PDB IDs		1WF1	Not available
GO Terms Enriched among Interactors		Nucleic Acid Binding MRNA Binding Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Ribonucleoprotein Complex Regulation Of MRNA Processing Response To Ether Nucleic Acid Metabolic Process RNA Metabolic Process Nucleus Regulation Of MRNA Metabolic Process Cytoplasmic Stress Granule RNA Binding Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Retrograde Transport, Endosome To Golgi RNA Processing Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Telomere Capping Positive Regulation Of Catabolic Process Regulation Of Exosomal Secretion Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Poly(U) RNA Binding Protein Binding Negative Regulation Of MRNA Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Postsynaptic Density Regulation Of Macromolecule Biosynthetic Process MRNA Processing SH3 Domain Binding Positive Regulation Of MRNA Catabolic Process Cytosol Cytoplasm Regulation Of Primary Metabolic Process Amyloid Fibril Formation Regulation Of Intracellular Transport Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Hepatocyte Dedifferentiation Cellular Response To Putrescine Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Formaldehyde Cellular Response To Vitamin B1	JUN Kinase Activity Regulation Of RNA Metabolic Process MAP Kinase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Fc-epsilon Receptor Signaling Pathway Protein Serine/threonine/tyrosine Kinase Activity Nucleus Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process JUN Phosphorylation