FHOD1 and LNPEP

Number of citations of the paper that reports this interaction (PubMedID 12677009)
0

Data Source:
HPRD (two hybrid, in vitro)

		FHOD1	LNPEP
Description		formin homology 2 domain containing 1	leucyl and cystinyl aminopeptidase
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GO Annotations	Cellular Component	Stress Fiber Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Intercalated Disc Membrane Bleb Cell Projection	Extracellular Region Lysosomal Membrane Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Lumen Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding Actin Filament Binding	Aminopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	Actin Filament Organization Nuclear Migration Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Establishment Of Centrosome Localization	Protein Polyubiquitination Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Proteolysis Cell-cell Signaling Female Pregnancy Regulation Of Blood Pressure Neuropeptide Catabolic Process Protein Catabolic Process Negative Regulation Of Cold-induced Thermogenesis
Pathways			Endosomal/Vacuolar pathway Translocation of SLC2A4 (GLUT4) to the plasma membrane Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Waist circumference adjusted for body mass index ( 34021172)	Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Ankylosing spondylitis ( 23749187) Birdshot chorioretinopathy ( 24957906) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233 28067908) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494)
Interacting Genes		22 interacting genes: ACTA1 ACTG1 APC BBS1 BBS2 BBS4 BBS7 CR2 EXOSC8 GRB2 LNPEP NCOA6 NLGN3 PFN2 PPARG PRKG1 RAC1 RANBP2 RNF5 TRIM21 YWHAZ ZMYND8	37 interacting genes: AGT AQP6 ASGR2 BIK CD79A CGRRF1 CTAG1A CTAG1B CYB5R3 FAM210B FATE1 FCER1G FHOD1 FKBP7 GGT7 GPR42 GPX8 LCN2 LHFPL5 MMGT1 REEP4 REL SLC10A1 SLC2A4 SLC35E3 SLC39A9 SMAD9 SSMEM1 STOM TAS2R19 TCF4 TLCD4 TMEM35A TNKS TNKS2 UBQLN1 UNC93A
Entrez ID		29109	4012
HPRD ID		06049	01041
Ensembl ID		ENSG00000135723	ENSG00000113441
Uniprot IDs		A0A068F7M9 Q9Y613	Q9UIQ6
PDB IDs		3DAD 6XF1 6XF2	4P8Q 4PJ6 4Z7I 5C97 5JHQ 5MJ6 7ZYF 8CGP 8CGW 8P0I
Enriched GO Terms of Interacting Partners?		BBSome Regulation Of Cell Motility Regulation Of Locomotion Dendrite Development Regulation Of Biological Quality Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Negative Regulation Of Immune Response Negative Regulation Of Innate Immune Response Regulation Of Microtubule-based Movement Non-motile Cilium Assembly Fat Cell Differentiation Ciliary Membrane Regulation Of Organelle Organization Regulation Of Metabolic Process Striatum Development Regulation Of Cilium Beat Frequency Positive Regulation Of Cellular Component Biogenesis Brain Morphogenesis Melanosome Transport Establishment Of Melanosome Localization Pigment Granule Transport Melanosome Localization Pigment Granule Localization Regulation Of Stress Fiber Assembly Regulation Of Supramolecular Fiber Organization Regulation Of Cell Projection Assembly Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Cytosol Regulation Of Cilium Movement Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Actin Filament Organization Cytoskeleton Organization Regulation Of Microtubule-based Process Photoreceptor Cell Maintenance Regulation Of Actin Filament Polymerization Centriolar Satellite Negative Regulation Of Defense Response Neuron Migration Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Actin Filament Polymerization Adult Behavior Cytoskeleton Regulation Of Cytoskeleton Organization Negative Regulation Of Metabolic Process Negative Regulation Of Immune System Process Negative Regulation Of Cell Migration Cellular Developmental Process Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Cell Motility	Membrane Positive Regulation Of Telomere Capping
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