FHOD1 and CR2

Number of citations of the paper that reports this interaction (PMID 15138285)
13

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		FHOD1	CR2
Gene Name		formin homology 2 domain containing 1	complement component (3d/Epstein Barr virus) receptor 2
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Membrane Bleb	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding	Complement Binding DNA Binding Complement Receptor Activity Transmembrane Signaling Receptor Activity Protein Homodimerization Activity
	Biological Process	Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Stress Fiber Assembly	Complement Receptor Mediated Signaling Pathway Immune Response Complement Activation, Classical Pathway B Cell Differentiation B Cell Proliferation Innate Immune Response
Pathways
Drugs
Diseases
GWAS			Type 2 diabetes ( 21490949)
Protein-Protein Interactions		20 interactors: ACTA1 ACTG1 APC BBS1 BBS2 BBS4 BBS7 CR2 EXOSC8 GRB2 LNPEP NCOA6 PFN2 PPARG PRKG1 RAC1 RANBP2 RNF5 YWHAZ ZMYND8	10 interactors: ANXA6 C3 CD19 CR1 FCER2 FHOD1 HNRNPU IFITM1 IFNA1 TP53
Entrez ID		29109	1380
HPRD ID		06049	00399
Ensembl ID		ENSG00000135723	ENSG00000117322
Uniprot IDs		Q9Y613	P20023
PDB IDs		3DAD	1GHQ 1LY2 1W2R 1W2S 2GSX 3OED
Enriched GO Terms of Interacting Partners?		Nonmotile Primary Cilium Assembly Cell Projection Organization Retina Homeostasis Cell Projection Morphogenesis Cell Part Morphogenesis Tissue Homeostasis Positive Regulation Of Organelle Organization Cellular Component Assembly Cell Morphogenesis Organelle Organization Multicellular Organismal Homeostasis Organelle Assembly Cytoskeleton Organization Cellular Response To Stimulus Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of Protein Polymerization Regulation Of Cell Projection Assembly Photoreceptor Cell Maintenance Cell Differentiation Cell Projection Assembly Fat Cell Differentiation Melanosome Transport Pigment Granule Transport Membrane Organization Establishment Of Melanosome Localization Response To Stimulus Positive Regulation Of Cellular Component Biogenesis Nervous System Development Regulation Of Organelle Organization Melanosome Localization Signal Transduction Cell Development Organ Development Homeostatic Process Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Complex Assembly Cilium Assembly Visual Perception Sensory Perception Of Light Stimulus Anatomical Structure Formation Involved In Morphogenesis Cell Activation Signaling Cilium Organization Leptin-mediated Signaling Pathway Cell Communication Cellular Pigmentation Platelet Activation Anatomical Structure Development Blood Coagulation	Regulation Of Immune Response Regulation Of Humoral Immune Response Immune Response Regulation Of Immune System Process Innate Immune Response Positive Regulation Of Humoral Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Adaptive Immune Response Regulation Of Complement Activation Immune System Process Positive Regulation Of Immunoglobulin Mediated Immune Response Positive Regulation Of Immune Response Humoral Immune Response Defense Response Adaptive Immune Response T Cell Activation Involved In Immune Response Positive Regulation Of Immune System Process Regulation Of Acute Inflammatory Response Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Hydrolase Activity Positive Regulation Of Cellular Protein Metabolic Process B Cell Differentiation Negative Regulation Of Macromitophagy Negative Regulation Of Complement Activation, Alternative Pathway Oligodendrocyte Apoptotic Process Positive Regulation Of Type IIa Hypersensitivity Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Lymphocyte Proliferation Mononuclear Cell Proliferation Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Protein Metabolic Process Leukocyte Proliferation Negative Regulation Of Helicase Activity Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Notch Signaling Pathway Complement Activation Signal Transduction Negative Regulation Of Complement Activation, Classical Pathway Positive Regulation Of Activation Of Membrane Attack Complex Positive Regulation Of Adaptive Immune Response Leukocyte Activation Involved In Immune Response B Cell Activation Defense Response To Virus Complement Receptor Mediated Signaling Pathway CRD-mediated MRNA Stabilization Protein Activation Cascade
Tagcloud ?		actin adhesions adhesive arrays assembly bilayers clusters coordinated depends find force formin impairs insights integrin integrins matrix maturation pillar polymerization question raises recruited rho sensing spreading steps substrates upstream	abolish abrogated adenovirus agar cooperation cotransfected cotransformation cr1 deletions dramatically e1a e1b embryo encode exon foci hypertransformation immortalization immortalizing impacted oncogenes plasmid plasmids prb soft src synergistically transformation v
Tagcloud (Difference) ?		actin adhesions adhesive arrays assembly bilayers clusters coordinated depends find force formin impairs insights integrin integrins matrix maturation pillar polymerization question raises recruited rho sensing spreading steps substrates upstream	abolish abrogated adenovirus agar cooperation cotransfected cotransformation cr1 deletions dramatically e1a e1b embryo encode exon foci hypertransformation immortalization immortalizing impacted oncogenes plasmid plasmids prb soft src synergistically transformation v
Tagcloud (Intersection) ?