FHOD1 and CR2

Number of citations of the paper that reports this interaction (PubMedID 15138285)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		FHOD1	CR2
Description		formin homology 2 domain containing 1	complement C3d receptor 2
Image
GO Annotations	Cellular Component	Stress Fiber Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Intercalated Disc Membrane Bleb Cell Projection	Extracellular Space Plasma Membrane Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding Actin Filament Binding	Virus Receptor Activity Complement Binding DNA Binding Complement Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Immunoglobulin Receptor Binding Protein Homodimerization Activity
	Biological Process	Actin Filament Organization Nuclear Migration Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Establishment Of Centrosome Localization	Immune System Process Complement Receptor Mediated Signaling Pathway T Cell Mediated Immunity Immune Response Complement Activation, Alternative Pathway Complement Activation, Classical Pathway B Cell Differentiation B Cell Proliferation B Cell Activation Innate Immune Response Negative Regulation Of Complement Activation, Classical Pathway Symbiont Entry Into Host Cell Type I Interferon-mediated Signaling Pathway Antiviral Innate Immune Response
Pathways			Regulation of Complement cascade
Drugs
Diseases
GWAS		Waist circumference adjusted for body mass index ( 34021172)	Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Refractive error ( 32231278) Systemic sclerosis ( 29293537) Type 2 diabetes ( 21490949)
Interacting Genes		22 interacting genes: ACTA1 ACTG1 APC BBS1 BBS2 BBS4 BBS7 CR2 EXOSC8 GRB2 LNPEP NCOA6 NLGN3 PFN2 PPARG PRKG1 RAC1 RANBP2 RNF5 TRIM21 YWHAZ ZMYND8	11 interacting genes: ANXA6 C3 CD19 CR1 FCER2 FHOD1 HNRNPU IFITM1 IFNA1 NCOA1 TP53
Entrez ID		29109	1380
HPRD ID		06049	00399
Ensembl ID		ENSG00000135723	ENSG00000117322
Uniprot IDs		A0A068F7M9 Q9Y613	P20023
PDB IDs		3DAD 6XF1 6XF2	1GHQ 1LY2 1W2R 1W2S 2ATY 2GSX 3OED 8SM0 8ZNI
Enriched GO Terms of Interacting Partners?		BBSome Regulation Of Cell Motility Regulation Of Locomotion Dendrite Development Regulation Of Biological Quality Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Negative Regulation Of Immune Response Negative Regulation Of Innate Immune Response Regulation Of Microtubule-based Movement Non-motile Cilium Assembly Fat Cell Differentiation Ciliary Membrane Regulation Of Organelle Organization Regulation Of Metabolic Process Striatum Development Regulation Of Cilium Beat Frequency Positive Regulation Of Cellular Component Biogenesis Brain Morphogenesis Melanosome Transport Establishment Of Melanosome Localization Pigment Granule Transport Melanosome Localization Pigment Granule Localization Regulation Of Stress Fiber Assembly Regulation Of Supramolecular Fiber Organization Regulation Of Cell Projection Assembly Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Cytosol Regulation Of Cilium Movement Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Actin Filament Organization Cytoskeleton Organization Regulation Of Microtubule-based Process Photoreceptor Cell Maintenance Regulation Of Actin Filament Polymerization Centriolar Satellite Negative Regulation Of Defense Response Neuron Migration Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Actin Filament Polymerization Adult Behavior Cytoskeleton Regulation Of Cytoskeleton Organization Negative Regulation Of Metabolic Process Negative Regulation Of Immune System Process Negative Regulation Of Cell Migration Cellular Developmental Process Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Cell Motility	Immune Effector Process Positive Regulation Of Humoral Immune Response Positive Regulation Of Activation Of Membrane Attack Complex Regulation Of Humoral Immune Response Protein-containing Complex Positive Regulation Of Complement Activation Interferon-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Leukocyte Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Activation Complement Receptor Mediated Signaling Pathway Complement Activation, Alternative Pathway Immune Response Immune System Process Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Immune Response-activating Signaling Pathway Lymphocyte Activation Involved In Immune Response Cell Surface Receptor Signaling Pathway Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Complement Activation Immune Response-regulating Signaling Pathway Activation Of Immune Response Leukocyte Activation Involved In Immune Response Signal Transduction Cell Activation Involved In Immune Response Negative Regulation Of Catalytic Activity Lymphocyte Activation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Regulation Of ATP-dependent Activity B Cell Activation Complement Activation, Classical Pathway Regulation Of Lymphocyte Mediated Immunity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Telomere Maintenance Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of Adaptive Immune Response Regulation Of Telomere Maintenance Via Telomerase Response To Other Organism Positive Regulation Of Immune Response Positive Regulation Of Immune Effector Process Innate Immune Response Complement Activation C5L2 Anaphylatoxin Chemotactic Receptor Binding Humoral Immune Response Complement Component C3b Receptor Activity Immune Complex Clearance By Erythrocytes Complement Component C4b Receptor Activity Negative Regulation Of Serine-type Endopeptidase Activity
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